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About Cystic Fibrosis | Cystic Fibrosis

Cystic fibrosis (CF) is a genetic disorder that causes problems with breathing and digestion. CF affects about 35,000 people in the United States. People with CF have mucus that is too thick and sticky, which

• blocks airways and leads to lung damage;
• traps germs and makes infections more likely; and
• prevents proteins needed for digestion from reaching the intestines, which decreases the body's ability to absorb nutrients from food.

CF affects many different organs in the body, making people with the disease more likely to develop other health conditions including diabetes, cirrhosis (liver disease), arthritis, reflux, hypersplenism (overactive spleen), and osteoporosis.

Signs of CF include

• salty-tasting skin
• cough that doesn't go away, often with thick mucus or blood
• wheezing or shortness of breath
• frequent lung or sinus infections
• nasal polyps (growths in the nose)
• poor growth or weight gain in childhood
• greasy, bad-smelling stools or constipation
• male infertility

Talk to your healthcare provider if you or your child shows signs of CF. A sweat test or genetic testing might be needed. If you or your child have been diagnosed with CF, you can find a CF Care Center near you.

CF results from genetic changes (mutations) in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which has instructions for making the CFTR protein. Everyone has two copies of the CFTR gene, one copy inherited from their mother and one from their father. A person must have genetic changes in both copies of the CFTR gene to have CF. This means that parents who each have a genetic change in only one copy of the CFTR gene, and therefore do not have the disorder themselves, can together have a child with CF.

The American College of Obstetricians and Gynecologists recommends that carrier screening for genetic disorders, including CF, be offered to anyone who is considering pregnancy or is currently pregnant. However, this carrier screening does not include all possible CF genetic changes. Because CF sometimes runs in families, if you have a family history of CF and decide to get screened, talk to your healthcare provider to make sure that you are tested for the genetic change that runs in your family. Your healthcare provider might refer you for genetic counseling and testing.

All babies born in the United States are checked for CF soon after birth as part of newborn screening. Finding babies with CF early is important so that they can start treatment right away, which can help delay or prevent complications of the disorder. Some people with CF show signs of the disorder soon after birth, although in milder cases, signs might not be seen until adulthood.

Available treatments can help people with CF live longer, healthier lives. Treatments for CF focus on improving breathing and digestion, preventing and treating infections, and thinning mucus. Treatments include medicines, therapy to clear mucus out of the lungs, and in some cases, lung transplant. Pharmacogenomic approaches have led to the development of medicines that target the underlying cause of the disorder. Because different CFTR genetic changes have different effects on the CFTR protein, these medicines can only be used to treat people with certain CFTR genetic changes.

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