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Vaccines for Moderately to Severely Immunocompromised People | COVID-19
Who is moderately or severely immunocompromised?
You can be immunocompromised (have a weakened immune system) because of a medical condition or if you received medications or treatments that suppress your immune system.
You can self-confirm if you are moderately or severely immunocompromised. This means you do NOT need documentation to receive a COVID-19 vaccination you are eligible for.
Vaccine recommendations for people who are moderately or severely immunocompromised
Certain vaccine brands are recommended for specific age groups. Learn more.
Initial COVID-19 vaccination series
If you have never had a COVID-19 vaccine, you start with an initial multi-dose series, given one time. The number of doses depends on your age and the vaccine brand you get.
Already completed initial series
- Children ages 6 months–4 years: Get 2 doses of 2024–2025 COVID-19 vaccine from the same brand (either Moderna or Pfizer-BioNTech, depending on what they received for their initial series) spaced 6 months apart.*
- Children ages 5–11 years: Get 2 doses of 2024–2025 COVID-19 vaccine from either brand (Moderna or Pfizer-BioNTech) spaced 6 months apart.*
- People ages 12 years and older: Get 2 doses of 2024–2025 COVID-19 vaccine from any brand (Moderna, Pfizer-BioNTech, or Novavax) spaced 6 months apart.*
Never received a COVID-19 vaccine
- Children ages 6 months–4 years: Get initial series of 2024–2025 COVID-19 vaccine from the same brand (either Moderna or Pfizer-BioNTech), followed by 1 dose from the same brand 6 months later.*
- Children ages 5–11 years: Get initial series of 2024–2025 vaccines from the same brand, followed by 1 dose from either brand (Moderna or Pfizer-BioNTech) 6 months later.*
- People ages 12 years and older: Get initial series of 2024–2025 COVID-19 vaccines from the same brand (Moderna, Pfizer-BioNTech, or Novavax), followed by 1 dose from any brand 6 months later.*
Started but did not complete initial series
- Children ages 6 months–4 years: Complete their initial series with the same vaccine brand they started with (Moderna or Pfizer-BioNTech). Then receive 1 more dose of 2024–2025 COVID-19 vaccine from the same brand 6 months later.*
- Children ages 5–11 years: Complete their initial series with the same vaccine brand they started with. Then receive 1 more dose of 2024-2025 COVID-19 vaccine from either brand (Moderna or Pfizer-BioNTech) 6 months later.*
- People ages 12 years and older: Complete the initial series with the same vaccine brand they started with. Then receive 1 more dose of 2024–2025 COVID-19 vaccine from any vaccine brand (Moderna, Pfizer-BioNTech, or Novavax) 6 months later.*
Note: For all age groups, it is recommended to use the same brand of COVID-19 vaccine doses for the initial series. In some situations, a COVID-19 vaccine from a different brand may be used. Talk to your healthcare provider for more information.
*While it is the recommended to get 2024-2025 COVID-19 vaccine doses 6 months apart, the minimum time is 2 months apart, which allows flexibility to get the second dose prior to typical COVID-19 surges, travel, life events, and healthcare visits.
Getting additional doses
After talking with a healthcare provider, people who are moderately or severely immunocompromised may get more doses (in addition to the ones described above) at least 2 months after their last dose of 2024–2025 COVID-19 vaccine. For children ages 6 months–4 years, these doses should be the same vaccine brand.
Get more details about these recommendations.
People who recently had COVID-19
- If you recently had COVID-19, you may delay getting a COVID-19 vaccine for 3 months from either the date your symptoms started or, if you didn't have symptoms, the date you received a positive test.
- The risk of getting COVID-19 is less likely in the weeks to months following a SARS-CoV-2 infection.
- Certain factors could be reasons to get a vaccine sooner rather than later, such as:
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