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Bioconductor - KnowSeq

KnowSeq

This is the released version of KnowSeq; for the devel version, see KnowSeq.

KnowSeq R/Bioc package: The Smart Transcriptomic Pipeline

Bioconductor version: Release (3.21)

KnowSeq proposes a novel methodology that comprises the most relevant steps in the Transcriptomic gene expression analysis. KnowSeq expects to serve as an integrative tool that allows to process and extract relevant biomarkers, as well as to assess them through a Machine Learning approaches. Finally, the last objective of KnowSeq is the biological knowledge extraction from the biomarkers (Gene Ontology enrichment, Pathway listing and Visualization and Evidences related to the addressed disease). Although the package allows analyzing all the data manually, the main strenght of KnowSeq is the possibilty of carrying out an automatic and intelligent HTML report that collect all the involved steps in one document. It is important to highligh that the pipeline is totally modular and flexible, hence it can be started from whichever of the different steps. KnowSeq expects to serve as a novel tool to help to the experts in the field to acquire robust knowledge and conclusions for the data and diseases to study.

Author: Daniel Castillo-Secilla [aut, cre], Juan Manuel Galvez [ctb], Francisco Carrillo-Perez [ctb], Marta Verona-Almeida [ctb], Daniel Redondo-Sanchez [ctb], Francisco Manuel Ortuno [ctb], Luis Javier Herrera [ctb], Ignacio Rojas [ctb]

Maintainer: Daniel Castillo-Secilla <cased at ugr.es>

Citation (from within R, enter citation("KnowSeq")): Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("KnowSeq")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("KnowSeq")

Details biocViews Alignment, BatchEffect, Classification, DataImport, DifferentialExpression, FeatureExtraction, GO, GeneExpression, GeneSetEnrichment, Genetics, ImmunoOncology, Microarray, Normalization, Pathways, Preprocessing, QualityControl, RNASeq, Sequencing, Software, SystemsBiology, Transcriptomics Version 1.22.0 In Bioconductor since BioC 3.10 (R-3.6) (5.5 years) License GPL (>=2) Depends R (>= 4.0), cqn(>= 1.28.1) Imports stringr, methods, ggplot2 (>= 3.3.0), jsonlite, kernlab, rlist, rmarkdown, reshape2, e1071, randomForest, caret, XML, praznik, R.utils, httr, sva(>= 3.30.1), edgeR(>= 3.24.3), limma(>= 3.38.3), grDevices, graphics, stats, utils, Hmisc (>= 4.4.0), gridExtra System Requirements URL See More Suggests knitr Linking To Enhances Depends On Me Imports Me Suggests Me Links To Me Build Report Build Report Package Archives

Follow Installation instructions to use this package in your R session.

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