This is the released version of ISLET; for the devel version, see ISLET.
Individual-Specific ceLl typE referencing ToolBioconductor version: Release (3.21)
ISLET is a method to conduct signal deconvolution for general -omics data. It can estimate the individual-specific and cell-type-specific reference panels, when there are multiple samples observed from each subject. It takes the input of the observed mixture data (feature by sample matrix), and the cell type mixture proportions (sample by cell type matrix), and the sample-to-subject information. It can solve for the reference panel on the individual-basis and conduct test to identify cell-type-specific differential expression (csDE) genes. It also improves estimated cell type mixture proportions by integrating personalized reference panels.
Author: Hao Feng [aut, cre] ORCID: 0000-0003-2243-9949 , Qian Li [aut], Guanqun Meng [aut]
Maintainer: Hao Feng <hxf155 at case.edu>
Citation (from within R, entercitation("ISLET")): Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("ISLET")
For older versions of R, please refer to the appropriate Bioconductor release.
DocumentationTo view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("ISLET")Follow Installation instructions to use this package in your R session.
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