This is the released version of sevenC; for the devel version, see sevenC.
Computational Chromosome Conformation Capture by Correlation of ChIP-seq at CTCF motifsBioconductor version: Release (3.21)
Chromatin looping is an essential feature of eukaryotic genomes and can bring regulatory sequences, such as enhancers or transcription factor binding sites, in the close physical proximity of regulated target genes. Here, we provide sevenC, an R package that uses protein binding signals from ChIP-seq and sequence motif information to predict chromatin looping events. Cross-linking of proteins that bind close to loop anchors result in ChIP-seq signals at both anchor loci. These signals are used at CTCF motif pairs together with their distance and orientation to each other to predict whether they interact or not. The resulting chromatin loops might be used to associate enhancers or transcription factor binding sites (e.g., ChIP-seq peaks) to regulated target genes.
Author: Jonas Ibn-Salem [aut, cre]
Maintainer: Jonas Ibn-Salem <jonas.ibn-salem at tron-mainz.de>
Citation (from within R, entercitation("sevenC")): Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("sevenC")
For older versions of R, please refer to the appropriate Bioconductor release.
DocumentationTo view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("sevenC")Follow Installation instructions to use this package in your R session.
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