This is the development version of scBFA; for the stable release version, see scBFA.
A dimensionality reduction tool using gene detection pattern to mitigate noisy expression profile of scRNA-seqBioconductor version: Development (3.22)
This package is designed to model gene detection pattern of scRNA-seq through a binary factor analysis model. This model allows user to pass into a cell level covariate matrix X and gene level covariate matrix Q to account for nuisance variance(e.g batch effect), and it will output a low dimensional embedding matrix for downstream analysis.
Author: Ruoxin Li [aut, cre], Gerald Quon [aut]
Maintainer: Ruoxin Li <uskli at ucdavis.edu>
Citation (from within R, entercitation("scBFA")
): Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
# The following initializes usage of Bioc devel
BiocManager::install(version='devel')
BiocManager::install("scBFA")
For older versions of R, please refer to the appropriate Bioconductor release.
DocumentationTo view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("scBFA")
Details biocViews ATACSeq, BatchEffect, DimensionReduction, GeneExpression, KEGG, QualityControl, SingleCell, Software, Transcriptomics Version 1.23.0 In Bioconductor since BioC 3.10 (R-3.6) (5.5 years) License GPL-3 + file LICENSE Depends R (>= 3.6) Imports SingleCellExperiment, SummarizedExperiment, Seurat, MASS, zinbwave, stats, copula, ggplot2, DESeq2, utils, grid, methods, Matrix System Requirements URL https://github.com/ucdavis/quon-titative-biology/BFA Bug Reports https://github.com/ucdavis/quon-titative-biology/BFA/issues See More Package Archives
Follow Installation instructions to use this package in your R session.
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