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Bioconductor - cpvSNP (development version)

cpvSNP

This is the development version of cpvSNP; for the stable release version, see cpvSNP.

Gene set analysis methods for SNP association p-values that lie in genes in given gene sets

Bioconductor version: Development (3.22)

Gene set analysis methods exist to combine SNP-level association p-values into gene sets, calculating a single association p-value for each gene set. This package implements two such methods that require only the calculated SNP p-values, the gene set(s) of interest, and a correlation matrix (if desired). One method (GLOSSI) requires independent SNPs and the other (VEGAS) can take into account correlation (LD) among the SNPs. Built-in plotting functions are available to help users visualize results.

Author: Caitlin McHugh, Jessica Larson, and Jason Hackney

Maintainer: Caitlin McHugh <mchughc at uw.edu>

Citation (from within R, enter citation("cpvSNP")): Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("cpvSNP")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("cpvSNP")
Running gene set analyses with the "cpvSNP" package PDF R Script Reference Manual PDF NEWS Text Details biocViews GeneSetEnrichment, Genetics, GenomicVariation, Pathways, Software, StatisticalMethod Version 1.41.0 In Bioconductor since BioC 3.1 (R-3.2) (10 years) License Artistic-2.0 Depends R (>= 3.5.0), GenomicFeatures, GSEABase(>= 1.24.0) Imports methods, corpcor, BiocParallel, ggplot2, plyr System Requirements URL See More Package Archives

Follow Installation instructions to use this package in your R session.


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