This is the development version of POWSC; for the stable release version, see POWSC.
Simulation, power evaluation, and sample size recommendation for single cell RNA-seqBioconductor version: Development (3.22)
Determining the sample size for adequate power to detect statistical significance is a crucial step at the design stage for high-throughput experiments. Even though a number of methods and tools are available for sample size calculation for microarray and RNA-seq in the context of differential expression (DE), this topic in the field of single-cell RNA sequencing is understudied. Moreover, the unique data characteristics present in scRNA-seq such as sparsity and heterogeneity increase the challenge. We propose POWSC, a simulation-based method, to provide power evaluation and sample size recommendation for single-cell RNA sequencing DE analysis. POWSC consists of a data simulator that creates realistic expression data, and a power assessor that provides a comprehensive evaluation and visualization of the power and sample size relationship.
Author: Kenong Su [aut, cre], Hao Wu [aut]
Maintainer: Kenong Su <kenong.su at emory.edu>
Citation (from within R, entercitation("POWSC")): Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
# The following initializes usage of Bioc devel
BiocManager::install(version='devel')
BiocManager::install("POWSC")
For older versions of R, please refer to the appropriate Bioconductor release.
Documentation Details biocViews DifferentialExpression, ImmunoOncology, SingleCell, Software Version 1.17.0 In Bioconductor since BioC 3.13 (R-4.1) (4 years) License GPL-2 Depends R (>= 4.1), Biobase, SingleCellExperiment, MAST Imports pheatmap, ggplot2, RColorBrewer, grDevices, SummarizedExperiment, limma System Requirements URL See More Package ArchivesFollow Installation instructions to use this package in your R session.
Source Package Windows Binary (x86_64) macOS Binary (x86_64) macOS Binary (arm64) Source Repository git clone https://git.bioconductor.org/packages/POWSC Source Repository (Developer Access) git clone git@git.bioconductor.org:packages/POWSC Package Short Url https://bioconductor.org/packages/POWSC/ Package Downloads Report Download StatsRetroSearch is an open source project built by @garambo | Open a GitHub Issue
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