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Bioconductor - MetaPhOR (development version)

MetaPhOR

This is the development version of MetaPhOR; for the stable release version, see MetaPhOR.

Metabolic Pathway Analysis of RNA

Bioconductor version: Development (3.22)

MetaPhOR was developed to enable users to assess metabolic dysregulation using transcriptomic-level data (RNA-sequencing and Microarray data) and produce publication-quality figures. A list of differentially expressed genes (DEGs), which includes fold change and p value, from DESeq2 or limma, can be used as input, with sample size for MetaPhOR, and will produce a data frame of scores for each KEGG pathway. These scores represent the magnitude and direction of transcriptional change within the pathway, along with estimated p-values.MetaPhOR then uses these scores to visualize metabolic profiles within and between samples through a variety of mechanisms, including: bubble plots, heatmaps, and pathway models.

Author: Emily Isenhart [aut, cre], Spencer Rosario [aut]

Maintainer: Emily Isenhart <emily.isenhart at roswellpark.org>

Citation (from within R, enter citation("MetaPhOR")): Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("MetaPhOR")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("MetaPhOR")
Details biocViews DifferentialExpression, GeneExpression, KEGG, Metabolomics, Microarray, Pathways, RNASeq, Sequencing, Software Version 1.11.0 In Bioconductor since BioC 3.16 (R-4.2) (2.5 years) License Artistic-2.0 Depends R (>= 4.2.0) Imports utils, ggplot2, ggrepel, stringr, pheatmap, grDevices, stats, clusterProfiler, RecordLinkage, RCy3 System Requirements Cytoscape (>= 3.9.0) for the cytoPath() examples URL See More Package Archives

Follow Installation instructions to use this package in your R session.


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