This is the development version of G4SNVHunter; for the stable release version, see G4SNVHunter.
Evaluating SNV-Induced Disruption of G-Quadruplex StructuresBioconductor version: Development (3.22)
G-quadruplexes (G4s) are unique nucleic acid secondary structures predominantly found in guanine-rich regions and have been shown to be involved in various biological regulatory processes. G4SNVHunter is an R package designed to rapidly identify genomic sequences with G4-forming propensity and to accurately screen user-provided single nucleotide variantsâas well as other small-scale variants such as indels and MNVsâfor their potential to destabilize these structures. This allows researchers to then screen these critical variants for deeper study, digging into how they might influence biological functionsâthink gene regulation, for instanceâby impairing G4 formation propensity.
Author: Rongxin Zhang [cre, aut] ORCID: 0000-0002-1643-1185
Maintainer: Rongxin Zhang <rongxinzhang at outlook.com>
Citation (from within R, entercitation("G4SNVHunter")): Installation
To install this package, start R (version "4.5") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
# The following initializes usage of Bioc devel
BiocManager::install(version='devel')
BiocManager::install("G4SNVHunter")
For older versions of R, please refer to the appropriate Bioconductor release.
DocumentationTo view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("G4SNVHunter")Follow Installation instructions to use this package in your R session.
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