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Bioconductor - DeepTarget (development version)

DeepTarget

This is the development version of DeepTarget; for the stable release version, see DeepTarget.

Deep characterization of cancer drugs

Bioconductor version: Development (3.22)

This package predicts a drug’s primary target(s) or secondary target(s) by integrating large-scale genetic and drug screens from the Cancer Dependency Map project run by the Broad Institute. It further investigates whether the drug specifically targets the wild-type or mutated target forms. To show how to use this package in practice, we provided sample data along with step-by-step example.

Author: Sanju Sinha [aut], Trinh Nguyen [aut, cre] ORCID: 0000-0002-6606-6948 , Ying Hu [aut]

Maintainer: Trinh Nguyen <tinh.nguyen at nih.gov>

Citation (from within R, enter citation("DeepTarget")): Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("DeepTarget")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("DeepTarget")
Workflow Demonstration for Deep characterization of cancer drugs HTML R Script Reference Manual PDF NEWS Text Details biocViews CRISPR, DifferentialExpression, GeneExpression, GenePrediction, GeneSetEnrichment, GeneTarget, ImmunoOncology, Pathways, RNASeq, ReportWriting, Software Version 1.3.0 In Bioconductor since BioC 3.20 (R-4.4) (0.5 years) License GPL-2 Depends R (>= 4.2.0) Imports fgsea, ggplot2, stringr, ggpubr, BiocParallel, pROC, stats, grDevices, graphics, depmap, readr, dplyr System Requirements URL See More Package Archives

Follow Installation instructions to use this package in your R session.


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