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Bioconductor - Coralysis (development version)

Coralysis

This is the development version of Coralysis; to use it, please install the devel version of Bioconductor.

Coralysis sensitive identification of imbalanced cell types and states in single-cell data via multi-level integration

Bioconductor version: Development (3.22)

Coralysis is an R package featuring a multi-level integration algorithm for sensitive integration, reference-mapping, and cell-state identification in single-cell data. The multi-level integration algorithm is inspired by the process of assembling a puzzle - where one begins by grouping pieces based on low-to high-level features, such as color and shading, before looking into shape and patterns. This approach progressively blends the batch effects and separates cell types across multiple rounds of divisive clustering.

Author: António Sousa [cre, aut] ORCID: 0000-0003-4779-6459 , Johannes Smolander [ctb, aut] ORCID: 0000-0003-3872-9668 , Sini Junttila [aut] ORCID: 0000-0003-3754-5584 , Laura L Elo [aut] ORCID: 0000-0001-5648-4532

Maintainer: António Sousa <aggode at utu.fi>

Citation (from within R, enter citation("Coralysis")): Installation

To install this package, start R (version "4.5") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

# The following initializes usage of Bioc devel
BiocManager::install(version='devel')

BiocManager::install("Coralysis")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("Coralysis")
Details biocViews Annotation, BatchEffect, Classification, Clustering, DifferentialExpression, DimensionReduction, GeneExpression, Proteomics, RNASeq, SingleCell, Software, Transcriptomics Version 0.99.9 In Bioconductor since BioC 3.22 (R-4.5) License GPL-3 Depends R (>= 4.2.0) Imports Matrix, aricode, LiblineaR, SparseM, ggplot2, umap, Rtsne, pheatmap, reshape2, dplyr, SingleCellExperiment, SummarizedExperiment, S4Vectors, methods, stats, utils, RANN, sparseMatrixStats, irlba, flexclust, scran, class, matrixStats, tidyr, cowplot, uwot, scatterpie, RColorBrewer, ggrastr, ggrepel, RSpectra, BiocParallel, withr System Requirements URL https://github.com/elolab/Coralysis https://elolab.github.io/Coralysis/ Bug Reports https://github.com/elolab/Coralysis/issues See More Suggests knitr, rmarkdown, bluster, ComplexHeatmap, circlize, scater, viridis, scRNAseq, SingleR, MouseGastrulationData, testthat (>= 3.0.0), BiocStyle, scrapper Linking To Enhances Depends On Me Imports Me Suggests Me Links To Me Build Report Build Report Package Archives

Follow Installation instructions to use this package in your R session.


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