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Showing content from https://pubmed.ncbi.nlm.nih.gov/7677489/ below:

Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group

Clinical Trial

Affiliations

• ¹ Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

• PMID: 7677489
• DOI: 10.1016/0003-4975(95)00537-u

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Clinical Trial

R J Ginsberg et al. Ann Thorac Surg. 1995 Sep.

• ¹ Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

• PMID: 7677489
• DOI: 10.1016/0003-4975(95)00537-u

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Background: It has been reported that limited resection (segment or wedge) is equivalent to lobectomy in the management of early stage (T1-2 N0) non-small cell lung cancer.

Methods: A prospective, multiinstitutional randomized trial was instituted comparing limited resection with lobectomy for patients with peripheral T1 N0 non-small cell lung cancer documented at operation. Analysis included locoregional and distant recurrence rates, 5-year survival rates, perioperative morbidity and mortality, and late pulmonary function assessment.

Results: There were 276 patients randomized, with 247 patients eligible for analysis. There were no significant differences for all stratification variables, selected prognostic factors, perioperative morbidity, mortality, or late pulmonary function. In patients undergoing limited resection, there was an observed 75% increase in recurrence rates (p = 0.02, one-sided) attributable to an observed tripling of the local recurrence rate (p = 0.008 two-sided), an observed 30% increase in overall death rate (p = 0.08, one-sided), and an observed 50% increase in death with cancer rate (p = 0.09, one-sided) compared to patients undergoing lobectomy (p = 0.10, one-sided was the predefined threshold for statistical significance for this equivalency study).

Conclusions: Compared with lobectomy, limited pulmonary resection does not confer improved perioperative morbidity, mortality, or late postoperative pulmonary function. Because of the higher death rate and locoregional recurrence rate associated with limited resection, lobectomy still must be considered the surgical procedure of choice for patients with peripheral T1 N0 non-small cell lung cancer.

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  Landreneau RJ, Sugarbaker DJ, Mack MJ, Hazelrigg SR, Luketich JD, Fetterman L, Liptay MJ, Bartley S, Boley TM, Keenan RJ, Ferson PF, Weyant RJ, Naunheim KS. Landreneau RJ, et al. J Thorac Cardiovasc Surg. 1997 Apr;113(4):691-8; discussion 698-700. doi: 10.1016/S0022-5223(97)70226-5. J Thorac Cardiovasc Surg. 1997. PMID: 9104978

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  De Zoysa MK, Hamed D, Routledge T, Scarci M. De Zoysa MK, et al. Interact Cardiovasc Thorac Surg. 2012 Jun;14(6):816-20. doi: 10.1093/icvts/ivs031. Epub 2012 Feb 27. Interact Cardiovasc Thorac Surg. 2012. PMID: 22374287 Free PMC article. Review.

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  Chamogeorgakis T, Ieromonachos C, Georgiannakis E, Mallios D. Chamogeorgakis T, et al. Interact Cardiovasc Thorac Surg. 2009 Mar;8(3):364-72. doi: 10.1510/icvts.2008.178947. Epub 2008 Jul 18. Interact Cardiovasc Thorac Surg. 2009. PMID: 18641014 Review.

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  Kobayashi Y, Fukui T, Ito S, Shitara K, Ito S, Hatooka S, Mitsudomi T. Kobayashi Y, et al. Surg Today. 2013 Dec;43(12):1382-9. doi: 10.1007/s00595-012-0432-1. Epub 2012 Nov 27. Surg Today. 2013. PMID: 23184359

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• [Issues Relevant to Surgical Intervention in 'Tiny' Non-small Cell Lung Cancer Detected by 'Lung Screening'--Orientation, Lung Resection and Lymph Node Resection].

  Liu D, Zhang Z. Liu D, et al. Zhongguo Fei Ai Za Zhi. 2016 Jun 20;19(6):347-50. doi: 10.3779/j.issn.1009-3419.2016.06.09. Zhongguo Fei Ai Za Zhi. 2016. PMID: 27335294 Free PMC article. Review. Chinese.

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