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Showing content from https://pubmed.ncbi.nlm.nih.gov/38486492/ below:

Association between time to colonoscopy after positive fecal testing and colorectal cancer outcomes in Alberta, Canada

Affiliations

• ¹ Department of Oncology, University of Calgary, Calgary, AB, Canada.
• ² Screening Programs, Alberta Health Services, Calgary, AB, Canada.

• PMID: 38486492
• PMCID: PMC11526417
• DOI: 10.1177/09691413241239023

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Darren R Brenner et al. J Med Screen. 2024 Dec.

• ¹ Department of Oncology, University of Calgary, Calgary, AB, Canada.
• ² Screening Programs, Alberta Health Services, Calgary, AB, Canada.

• PMID: 38486492
• PMCID: PMC11526417
• DOI: 10.1177/09691413241239023

Item in Clipboard

Objective: To quantify the associations between time to colonoscopy after a positive fecal immunochemical test (FIT+) and colorectal cancer (CRC)-related outcomes in the context of a provincial, population-based CRC screening program.

Setting: Population-based, retrospective cohort study in Alberta, Canada, including Albertans aged 50-74 with at least one FIT+ in 2014-2017.

Methods: Study outcomes were CRC diagnosis after a FIT+ and a diagnostic follow-up colonoscopy in 2014-2019 and CRC stage at diagnosis. Multivariable logistic regression models were used to evaluate the relative risk of any CRC or advanced-stage CRC. Results were presented as crude odds ratio (OR) and adjusted OR (aOR) with 95% confidence intervals (CIs).

Results: Of the 787,967 participants who had a FIT, 63,232 (8%) had a FIT+ and met the study's eligibility criteria. The risk of any CRC or advanced-stage CRC stayed high and was relatively consistent for follow-up colonoscopies performed within 1-12 months of the FIT+. After 12 months, the risk of CRC was considerably higher, particularly for advanced-stage CRC. The OR and aOR for any CRC were 1.40 (95% CI: 1.13-1.73; p < 0.05) and 1.20 (95% CI: 0.96-1.49), respectively, and the OR and aOR for advanced-stage CRC were 1.42 (95% CI: 0.98-2.08) and 0.88 (95% CI: 0.59-1.32), respectively, for colonoscopy follow-up within 12-18 months versus 1-2 months.

Conclusions: For Albertans who used FIT for CRC screening, a longer time interval between a FIT+ and follow-up colonoscopy, particularly over 12 months, increases the risk of having CRC and decreases the effectiveness of CRC screening programs.

Keywords: Colorectal cancer; cancer screening; colonoscopy; fecal immunochemical test; retrospective cohort study.

PubMed Disclaimer

Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Study inclusion/exclusion of participants in…

Study inclusion/exclusion of participants in Alberta's Colorectal Cancer Screening Program in 2014–2017 after…

Study inclusion/exclusion of participants in Alberta's Colorectal Cancer Screening Program in 2014–2017 after applying relevant eligibility criteria.

Time to colonoscopy after positive…

Time to colonoscopy after positive fecal immunochemical test results between 2014 and 2019…

Time to colonoscopy after positive fecal immunochemical test results between 2014 and 2019 in Alberta by waiting time in months, up to 24 months.

• Time to Colonoscopy and Risk of Colorectal Cancer in Patients With Positive Results From Fecal Immunochemical Tests.

  Lee YC, Fann JC, Chiang TH, Chuang SL, Chen SL, Chiu HM, Yen AM, Chiu SY, Hsu CY, Hsu WF, Wu MS, Chen HH. Lee YC, et al. Clin Gastroenterol Hepatol. 2019 Jun;17(7):1332-1340.e3. doi: 10.1016/j.cgh.2018.10.041. Epub 2018 Nov 1. Clin Gastroenterol Hepatol. 2019. PMID: 30391435

• Interval Colorectal Cancer Incidence Among Subjects Undergoing Multiple Rounds of Fecal Immunochemical Testing.

  van der Vlugt M, Grobbee EJ, Bossuyt PMM, Bos A, Bongers E, Spijker W, Kuipers EJ, Lansdorp-Vogelaar I, Spaander MCW, Dekker E. van der Vlugt M, et al. Gastroenterology. 2017 Aug;153(2):439-447.e2. doi: 10.1053/j.gastro.2017.05.004. Epub 2017 May 5. Gastroenterology. 2017. PMID: 28483499

• Enhancing colorectal cancer screening in high-risk population through fecal immunochemical test surveillance: Results from a surveillance program.

  Qin H, Zhang M, Zhang G, Zhao L, Zhang H, Zhang W, Wang Y, Zhang X, Xie L, Qian B. Qin H, et al. Cancer Med. 2024 Oct;13(20):e70145. doi: 10.1002/cam4.70145. Cancer Med. 2024. PMID: 39428708 Free PMC article.

• Association Between Time to Colonoscopy After Positive Fecal Testing and Colorectal Cancer Outcomes: A Systematic Review.

  Forbes N, Hilsden RJ, Martel M, Ruan Y, Dube C, Rostom A, Shorr R, Menard C, Brenner DR, Barkun AN, Heitman SJ. Forbes N, et al. Clin Gastroenterol Hepatol. 2021 Jul;19(7):1344-1354.e8. doi: 10.1016/j.cgh.2020.09.048. Epub 2020 Oct 1. Clin Gastroenterol Hepatol. 2021. PMID: 33010414 Free PMC article. Review.

• Challenges around diagnosis of early onset colorectal cancer, and the case for screening.

  Waddell O, Keenan J, Frizelle F. Waddell O, et al. ANZ J Surg. 2024 Oct;94(10):1687-1692. doi: 10.1111/ans.19221. Epub 2024 Aug 29. ANZ J Surg. 2024. PMID: 39206626 Review.

1. 1. Brenner DR, Poirier A, Woods RR, et al. Projected estimates of cancer in Canada in 2022. CMAJ 2022; 194: E601–E607. - PMC - PubMed
2. 1. Roselló S, Simón S, Cervantes A. Programmed colorectal cancer screening decreases incidence and mortality. Transl Gastroenterol Hepatol 2019; 4: 84. - PMC - PubMed
3. 1. Gini A, Jansen EEL, Zielonke N, et al. Impact of colorectal cancer screening on cancer-specific mortality in Europe: A systematic review. Eur J Cancer 2020; 127: 224–235. - PubMed
4. 1. Cardoso R, Guo F, Heisser T, et al. Colorectal cancer incidence, mortality, and stage distribution in European countries in the colorectal cancer screening era: An international population-based study. Lancet Oncol 2021; 22: 1002–1013. - PubMed
5. 1. Robertson DJ, Lee JK, Boland CR, et al. Recommendations on fecal immunochemical testing to screen for colorectal neoplasia: A consensus statement by the US multi-society task force on colorectal cancer. Gastroenterology 2017; 152: 1217–1237.e3. - PubMed

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