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Showing content from https://pubmed.ncbi.nlm.nih.gov/38400188/ below:

Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy

doi: 10.3390/vaccines12020205. Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy Silvia Angelillo², Aida Bianco³, Gabriella Di Giuseppe¹, Valeria Di Onofrio⁴, Francesca Licata², Giorgio Liguori⁵, Carmelo Giuseppe Angelo Nobile⁶, Maria Pavia¹, Concetta Paola Pelullo⁵, Federica Zito Marino⁷, Italo Francesco Angelillo¹

Affiliations

¹ Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
² Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
³ Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
⁴ Department of Sciences and Technologies, University of Naples "Parthenope", 80143 Naples, Italy.
⁵ Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy.
⁶ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy.
⁷ Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

PMID: 38400188
PMCID: PMC10892725
DOI: 10.3390/vaccines12020205

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Genital and Oral HPV Geno-Prevalence Measured through Urine and Saliva Samples in Young Adults in Italy

Francesco Napolitano et al. Vaccines (Basel). 2024.

doi: 10.3390/vaccines12020205. Authors Francesco Napolitano¹, Silvia Angelillo², Aida Bianco³, Gabriella Di Giuseppe¹, Valeria Di Onofrio⁴, Francesca Licata², Giorgio Liguori⁵, Carmelo Giuseppe Angelo Nobile⁶, Maria Pavia¹, Concetta Paola Pelullo⁵, Federica Zito Marino⁷, Italo Francesco Angelillo¹ Affiliations

¹ Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.
² Department of Health Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
³ Department of Medical and Surgical Sciences, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
⁴ Department of Sciences and Technologies, University of Naples "Parthenope", 80143 Naples, Italy.
⁵ Department of Medical, Movement and Wellbeing Sciences, University of Naples "Parthenope", 80133 Naples, Italy.
⁶ Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy.
⁷ Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

PMID: 38400188
PMCID: PMC10892725
DOI: 10.3390/vaccines12020205

Item in Clipboard

Abstract

Background: The aims of the study were to determine, in the urine and oral samples of young adults, the genotype-specific prevalence of Human Papilloma Virus (HPV) infection, the HPV DNA type-specific prevalence in unvaccinated and vaccinated individuals, and the determinants of HPV infection.

Methods: Selected participants were asked to fill in a self-administered questionnaire and to self-collect urine and saliva samples.

Results: Among the 1002 participants, 81 (8.1%) resulted positive for HPV DNA. The most common low-risk genotype was HPV 42 (2.2%), followed by HPV 43 (0.8%), and 40 (0.5%). The HPV 51 was the most common high-risk genotype (1.5%) followed by HPV 66 (1%) and HPV 68 (1%), and no participants were infected with HPV genotypes 18, 33, 45. Females, those who have had one or more occasional sexual partner, those who never/rarely/sometimes used condoms during their sexual activity, those with a previous diagnosis of sexually transmitted infection, and those who were not vaccinated were more likely to be tested positive for HPV infection.

Conclusions: The low prevalence of genital HPV infections has provided evidence of the effectiveness of HPV vaccination both in vaccinated and not yet vaccinated subjects through herd immunity and indicated its decisive role in the changing epidemiology of circulating HPV genotypes in the population.

Keywords: HPV vaccination; geno-prevalence; saliva; urine; young adults.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.