RetroSearch Browse

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/36910056/ below:

Real-world evidence of safety and influence for lung cancer surgery under COVID-19 pandemic in Japan

. 2023 Feb 28;15(2):542-551. doi: 10.21037/jtd-22-1289. Epub 2023 Feb 3. Real-world evidence of safety and influence for lung cancer surgery under COVID-19 pandemic in Japan Ryotaro Katsuya¹, Shoji Okado¹, Keiyu Sato¹, Osamu Noritake¹, Keita Nakanishi¹, Misa Noguchi¹, Yuka Kadomatsu¹, Harushi Ueno¹, Naoki Ozeki¹, Shota Nakamura¹, Koichi Fukumoto¹, Toyofumi Fengshi Chen-Yoshikawa¹

Affiliations

Affiliation

¹ Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

PMID: 36910056
PMCID: PMC9992575
DOI: 10.21037/jtd-22-1289

Item in Clipboard

Real-world evidence of safety and influence for lung cancer surgery under COVID-19 pandemic in Japan

Taketo Kato et al. J Thorac Dis. 2023.

. 2023 Feb 28;15(2):542-551. doi: 10.21037/jtd-22-1289. Epub 2023 Feb 3. Authors Taketo Kato¹, Ryotaro Katsuya¹, Shoji Okado¹, Keiyu Sato¹, Osamu Noritake¹, Keita Nakanishi¹, Misa Noguchi¹, Yuka Kadomatsu¹, Harushi Ueno¹, Naoki Ozeki¹, Shota Nakamura¹, Koichi Fukumoto¹, Toyofumi Fengshi Chen-Yoshikawa¹ Affiliation

¹ Department of Thoracic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

PMID: 36910056
PMCID: PMC9992575
DOI: 10.21037/jtd-22-1289

Item in Clipboard

Abstract

Background: The COVID-19 pandemic has affected the clinical practice of lung cancer surgery in Japan, but few studies have revealed the real situation of surgical practice for lung cancer in this country. This latest information will help us to decide the future direction of lung cancer surgery under pandemic circumstances.

Methods: We collected data from patients with primary lung cancer who underwent thoracic surgery between 2018 and 2021. To investigate the impact of the COVID-19 pandemic on lung cancer surgery, we compared between 2018-2019 (prepandemic group) and 2020-2021 (pandemic group) in the respect of patient characteristics, pathological findings, and short-term outcome after lung cancer resection by Mann-Whitney and Fisher's exact tests. Moreover, the monthly number of surgeries for lung cancer in our institution during 2020-2021 was compared with the number of newly diagnosed COVID-19 patients in Japan by Spearman correlation analysis.

Results: From 2018 through 2021, 936 patients with primary lung cancer underwent surgical intervention in our institute and were included in this study. The number of surgeries did not decrease in the pandemic group (n=443) compared with that in the prepandemic group (n=493). Tumor and invasive size in stage I which was measured by pathologist were significantly larger in the pandemic group than in the prepandemic group (tumor size: P=0.031, invasive size: P<0.001). In terms of postoperative short-term outcome, the median hospital stay was 6 days, 30-day mortality was 2, and morbidity was around 20% in both groups. Only one patient suffered from COVID-19 infection 5 months after right upper lobectomy. An increased ratio of newly diagnosed COVID-19 cases in Japan was negatively correlated with the number of surgeries for lung cancer in our institution in the next month (r=-0.393, P=0.007), although there was no correlation in the present or the month after next.

Conclusions: Even during the COVID-19 pandemic period, lung cancer surgery could be performed safely and in a sustainable manner. However, pathological findings of lung cancer tended to be progressive in early-stage lung cancer.

Keywords: COVID-19; lung cancer surgery; pandemic; short-term outcome; tumor enlargement.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-1289/coif). The authors have no conflicts of interest to declare.

Figures
Figure 1

Bar graphs showing the distribution…

Figure 1

Bar graphs showing the distribution of pathological stage I lung cancer. (A) The…

Figure 1

Bar graphs showing the distribution of pathological stage I lung cancer. (A) The counts of stage I diseases are compared between 2018–2019 and 2020–2021. After the pandemic, a decrease was observed only in stage IA1, with the largest increase seen in stage IB. (B) An annual comparison of stage I disease shows that stage IA3 and IB tumors were notably increased in 2021.

Figure 2

Tumor and invasive sizes of…

Figure 2

Tumor and invasive sizes of stage I lung cancers are compared between 2018–2019…

Figure 2

Tumor and invasive sizes of stage I lung cancers are compared between 2018–2019 and 2020–2021. The sizes in the pandemic group were significantly larger than those in the prepandemic group (tumor size: P=0.031, invasive size: P<0.001). Median tumor and invasive sizes and interquartile range were summarized by violin plot. *, P<0.05; ***, P<0.001.

Figure 3

Comparison of the volume of…

Figure 3

Comparison of the volume of lung cancer surgery in our department with new…

Figure 3

Comparison of the volume of lung cancer surgery in our department with new COVID-19 cases in Japan and Aichi during the pandemic period. The first pandemic wave occurred in April 2020. The number of cases undergoing operation decreased around April. Under the third and fourth waves, the number of cases receiving an operation decreased again in a delayed fashion.

Figure 4

Scatter plots showing the relationship…

Figure 4

Scatter plots showing the relationship between the increase ratio of new COVID-19 cases…

Figure 4

Scatter plots showing the relationship between the increase ratio of new COVID-19 cases in Japan and operation volume in the present month, next month, and the month after next. A significant negative correlation was detected between the increase ratio of COVID-19 and operation volume in the next month (r=−0.393, P=0.007). Red plots indicate that the increase ratio of COVID-19 cases was >100%, and green plots indicate that the increase ratio of COVID-19 was ≤100%.