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Model-Based Estimation of Colorectal Cancer Screening and Outcomes During the COVID-19 Pandemic

. 2021 Apr 1;4(4):e216454. doi: 10.1001/jamanetworkopen.2021.6454. Model-Based Estimation of Colorectal Cancer Screening and Outcomes During the COVID-19 Pandemic

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Model-Based Estimation of Colorectal Cancer Screening and Outcomes During the COVID-19 Pandemic

Rachel B Issaka et al. JAMA Netw Open. 2021.

. 2021 Apr 1;4(4):e216454. doi: 10.1001/jamanetworkopen.2021.6454. Affiliations

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Abstract

Importance: COVID-19 has decreased colorectal cancer screenings.

Objective: To estimate the degree to which expanding fecal immunochemical test-based colorectal cancer screening participation during the COVID-19 pandemic is associated with clinical outcomes.

Design, setting, and participants: A previously developed simulation model was adopted to estimate how much COVID-19 may have contributed to colorectal cancer outcomes. The model included the US population estimated to have completed colorectal cancer screening pre-COVID-19 according the American Cancer Society. The model was designed to estimate colorectal cancer outcomes between 2020 and 2023. This analysis was completed between July and December 2020.

Exposures: Adults screened for colorectal cancer and colorectal cancer cases detected by stage.

Main outcomes and measures: Estimates of colorectal cancer outcomes across 4 scenarios: (1) 9 months of 50% colorectal cancer screenings followed by 21 months of 75% colorectal cancer screenings; (2) 18 months of 50% screening followed by 12 months of 75% screening; (3) scenario 1 with increased use of fecal immunochemical tests; and (4) scenario 2 with increased use of fecal immunochemical tests.

Results: In our simulation model, COVID-19-related reductions in care utilization resulted in an estimated 1 176 942 to 2 014 164 fewer colorectal cancer screenings, 8346 to 12 894 fewer colorectal cancer diagnoses, and 6113 to 9301 fewer early-stage colorectal cancer diagnoses between 2020 and 2023. With an abbreviated period of reduced colorectal cancer screenings, increasing fecal immunochemical test use was associated with an estimated additional 588 844 colorectal cancer screenings and 2836 colorectal cancer diagnoses, of which 1953 (68.9%) were early stage. In the event of a prolonged period of reduced colorectal cancer screenings, increasing fecal immunochemical test use was associated with an estimated additional 655 825 colorectal cancer screenings and 2715 colorectal cancer diagnoses, of which 1944 (71.6%) were early stage.

Conclusions and relevance: These results suggest that the increased use of fecal immunochemical tests during the COVID-19 pandemic was associated with increased colorectal cancer screening participation and more colorectal cancer diagnoses at earlier stages. If our estimates are borne out in real-world clinical practice, increasing fecal immunochemical test-based colorectal cancer screening participation during the COVID-19 pandemic could mitigate the consequences of reduced screening rates during the pandemic for colorectal cancer outcomes.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Ramsey reported receiving consulting fees from Epigenomics as an advisor outside the submitted work. No other disclosures were reported.

Figures

Figure 1.. Schematic of Modeled COVID-19 Scenarios

Figure 1.. Schematic of Modeled COVID-19 Scenarios

 Figure 1.. Schematic of Modeled COVID-19 Scenarios

Figure 2.. Baseline Screening Population

Figure 2.. Baseline Screening Population

 Figure 2.. Baseline Screening Population Similar articles Cited by References
    1. Siegel RL, Miller KD, Goding Sauer A, et al. . Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145-164. doi:10.3322/caac.21601 - DOI - PubMed
    1. Heitman SJ, Hilsden RJ, Au F, Dowden S, Manns BJ. Colorectal cancer screening for average-risk North Americans: an economic evaluation. PLoS Med. 2010;7(11):e1000370. doi:10.1371/journal.pmed.1000370 - DOI - PMC - PubMed
    1. Baxter NN, Goldwasser MA, Paszat LF, Saskin R, Urbach DR, Rabeneck L. Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2009;150(1):1-8. doi:10.7326/0003-4819-150-1-200901060-00306 - DOI - PubMed
    1. Mandel JS, Bond JH, Church TR, et al. ; Minnesota Colon Cancer Control Study . Reducing mortality from colorectal cancer by screening for fecal occult blood. N Engl J Med. 1993;328(19):1365-1371. doi:10.1056/NEJM199305133281901 - DOI - PubMed
    1. Cyhaniuk A, Coombes ME. Longitudinal adherence to colorectal cancer screening guidelines. Am J Manag Care. 2016;22(2):105-111. - PubMed

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