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Showing content from https://pubmed.ncbi.nlm.nih.gov/32821935/ below:

Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Disproportionately Affects the Latinx Population During Shelter-in-Place in San Francisco

. 2021 Jul 30;73(Suppl 2):S127-S135. doi: 10.1093/cid/ciaa1234. Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Disproportionately Affects the Latinx Population During Shelter-in-Place in San Francisco Carina Marquez¹, Emily Crawford^{1 2}, James Peng¹, Maya Petersen³, Daniel Schwab⁴, Joshua Schwab³, Jackie Martinez¹, Diane Jones⁵, Douglas Black¹, Monica Gandhi¹, Andrew D Kerkhoff¹, Vivek Jain¹, Francesco Sergi¹, Jon Jacobo⁶, Susana Rojas⁶, Valerie Tulier-Laiwa⁶, Tracy Gallardo-Brown⁶, Ayesha Appa¹, Charles Chiu¹, Mary Rodgers⁷, John Hackett⁷; CLIAhub Consortium; Amy Kistler², Samantha Hao², Jack Kamm², David Dynerman², Joshua Batson², Bryan Greenhouse¹, Joe DeRisi^{1 2}, Diane V Havlir¹

Affiliations

¹ University of California, San Francisco, San Francisco, California, USA.
² Chan Zuckerberg Biohub, San Francisco, California, USA.
³ University of California, Berkeley, Berkeley, California, USA.
⁴ College of the Holy Cross, Worcester, Massachusetts, USA.
⁵ Unidos en Salud/United in Health, San Francisco, California, USA.
⁶ Latino Task Force for COVID-19, San Francisco, California, USA.
⁷ Abbott Laboratories, Abbott Park, Illinois, USA.

PMID: 32821935
PMCID: PMC7499499
DOI: 10.1093/cid/ciaa1234

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Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 Disproportionately Affects the Latinx Population During Shelter-in-Place in San Francisco

Gabriel Chamie et al. Clin Infect Dis. 2021.

. 2021 Jul 30;73(Suppl 2):S127-S135. doi: 10.1093/cid/ciaa1234. Authors Gabriel Chamie¹, Carina Marquez¹, Emily Crawford^{1 2}, James Peng¹, Maya Petersen³, Daniel Schwab⁴, Joshua Schwab³, Jackie Martinez¹, Diane Jones⁵, Douglas Black¹, Monica Gandhi¹, Andrew D Kerkhoff¹, Vivek Jain¹, Francesco Sergi¹, Jon Jacobo⁶, Susana Rojas⁶, Valerie Tulier-Laiwa⁶, Tracy Gallardo-Brown⁶, Ayesha Appa¹, Charles Chiu¹, Mary Rodgers⁷, John Hackett⁷; CLIAhub Consortium; Amy Kistler², Samantha Hao², Jack Kamm², David Dynerman², Joshua Batson², Bryan Greenhouse¹, Joe DeRisi^{1 2}, Diane V Havlir¹ Affiliations

¹ University of California, San Francisco, San Francisco, California, USA.
² Chan Zuckerberg Biohub, San Francisco, California, USA.
³ University of California, Berkeley, Berkeley, California, USA.
⁴ College of the Holy Cross, Worcester, Massachusetts, USA.
⁵ Unidos en Salud/United in Health, San Francisco, California, USA.
⁶ Latino Task Force for COVID-19, San Francisco, California, USA.
⁷ Abbott Laboratories, Abbott Park, Illinois, USA.

PMID: 32821935
PMCID: PMC7499499
DOI: 10.1093/cid/ciaa1234

Item in Clipboard

Abstract

Background: There is an urgent need to understand the dynamics and risk factors driving ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during shelter-in-place mandates.

Methods: We offered SARS-CoV-2 reverse-transcription polymerase chain reaction (PCR) and antibody (Abbott ARCHITECT IgG) testing, regardless of symptoms, to all residents (aged ≥4 years) and workers in a San Francisco census tract (population: 5174) at outdoor, community-mobilized events over 4 days. We estimated SARS-CoV-2 point prevalence (PCR positive) and cumulative incidence (antibody or PCR positive) in the census tract and evaluated risk factors for recent (PCR positive/antibody negative) vs prior infection (antibody positive/PCR negative). SARS-CoV-2 genome recovery and phylogenetics were used to measure viral strain diversity, establish viral lineages present, and estimate number of introductions.

Results: We tested 3953 persons (40% Latinx; 41% White; 9% Asian/Pacific Islander; and 2% Black). Overall, 2.1% (83/3871) tested PCR positive: 95% were Latinx and 52% were asymptomatic when tested; 1.7% of census tract residents and 6.0% of workers (non-census tract residents) were PCR positive. Among 2598 tract residents, estimated point prevalence of PCR positives was 2.3% (95% confidence interval [CI], 1.2%-3.8%): 3.9% (95% CI, 2.0%-6.4%) among Latinx persons vs 0.2% (95% CI, .0-.4%) among non-Latinx persons. Estimated cumulative incidence among residents was 6.1% (95% CI, 4.0%-8.6%). Prior infections were 67% Latinx, 16% White, and 17% other ethnicities. Among recent infections, 96% were Latinx. Risk factors for recent infection were Latinx ethnicity, inability to shelter in place and maintain income, frontline service work, unemployment, and household income <$50 000/year. Five SARS-CoV-2 phylogenetic lineages were detected.

Conclusions: SARS-CoV-2 infections from diverse lineages continued circulating among low-income, Latinx persons unable to work from home and maintain income during San Francisco's shelter-in-place ordinance.

Keywords: asymptomatic SARS-CoV-2 infection; community-based SARS-CoV-2 testing; ethnic disparities; phylogenetic analysis; shelter-in-place.

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