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Patient-reported financial toxicity in multiple sclerosis: Predictors and association with care non-adherence

. 2021 Mar;27(3):453-464. doi: 10.1177/1352458520913977. Epub 2020 Aug 18. Patient-reported financial toxicity in multiple sclerosis: Predictors and association with care non-adherence

Affiliations

¹ Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, USA.
² Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA.
³ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
⁴ Harvey L. Neiman Health Policy Institute, Reston, VA, USA; School of Economics, Georgia Institute of Technology, Atlanta, GA, USA.
⁵ Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

PMID: 32808562
DOI: 10.1177/1352458520913977

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Patient-reported financial toxicity in multiple sclerosis: Predictors and association with care non-adherence

Gelareh Sadigh et al. Mult Scler. 2021 Mar.

. 2021 Mar;27(3):453-464. doi: 10.1177/1352458520913977. Epub 2020 Aug 18. Affiliations

¹ Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA, USA.
² Department of Neurology, School of Medicine, Emory University, Atlanta, GA, USA.
³ Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
⁴ Harvey L. Neiman Health Policy Institute, Reston, VA, USA; School of Economics, Georgia Institute of Technology, Atlanta, GA, USA.
⁵ Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

PMID: 32808562
DOI: 10.1177/1352458520913977

Item in Clipboard

Abstract

Background: Multiple sclerosis (MS) results in considerable financial burdens due to expensive treatment and high rates of disability, which could both impact care non-adherence.

Objective: To measure financial toxicity in MS patients, identify its predictors and association with care non-adherence.

Methods: Adult MS patients visiting neurology clinic (June 2018 to February 2019) were consented to complete a survey. Financial toxicity was measured using Comprehensive Score for Financial Toxicity (COST) (range: 0-44, the lower the score, the worse the financial toxicity). Independent predictors of financial toxicity were identified using linear regression. Associations of COST score with patient outcomes were assessed.

Results: The mean COST score in 243 recruited patients was 17.4 ± 10.2. In response to financial burdens, 66.7% and 34.7% reported life-style altering behaviors or care non-adherence, respectively. Higher financial self-efficacy was associated with less financial toxicity (coefficient, 1.33 (95% confidence interval (CI), 1.02-1.64); p < 0.001). At least one relapse in the last 3 months was associated with greater financial toxicity (coefficient, -3.34 (95% CI, -6.66 to -0.01); p = 0.049). Greater financial toxicity correlated with life-style-altering coping strategy use (p < 0.001), care non-adherence (p = 0.001), and worse health-related quality of life (HRQOL) (p = 0.03).

Conclusion: MS patients with lower financial self-efficacy and prior relapse history are at higher risk for financial toxicity, with associated care non-adherence and lower HRQOL.

Keywords: Multiple sclerosis; care non-adherence; financial toxicity; health-related quality of life; outcomes.

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