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Showing content from https://pubmed.ncbi.nlm.nih.gov/32804317/ below:

The relationship between diabetes and clinical outcomes in COVID-19: a single-center retrospective analysis

Observational Study

Affiliations

• ¹ Department of Medicine, Einstein Medical Center Philadelphia, 5501 Old York Road, Philadelphia, PA, 19141, USA. FoxTamar@einstein.edu.
• ² Department of Medicine, Einstein Medical Center Philadelphia, 5501 Old York Road, Philadelphia, PA, 19141, USA.
• ³ Department of Endocrinology, Einstein Medical Center Philadelphia, Philadelphia, USA.
• ⁴ Sidney Kimmel College of Thomas Jefferson University, Philadelphia, PA, USA.
• ⁵ Pulmonary, Critical Care and Sleep Medicine, Einstein Medical Center Philadelphia, Philadelphia, USA.

• PMID: 32804317
• PMCID: PMC7429932
• DOI: 10.1007/s00592-020-01592-8

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Observational Study

Tamaryn Fox et al. Acta Diabetol. 2021 Jan.

• ¹ Department of Medicine, Einstein Medical Center Philadelphia, 5501 Old York Road, Philadelphia, PA, 19141, USA. FoxTamar@einstein.edu.
• ² Department of Medicine, Einstein Medical Center Philadelphia, 5501 Old York Road, Philadelphia, PA, 19141, USA.
• ³ Department of Endocrinology, Einstein Medical Center Philadelphia, Philadelphia, USA.
• ⁴ Sidney Kimmel College of Thomas Jefferson University, Philadelphia, PA, USA.
• ⁵ Pulmonary, Critical Care and Sleep Medicine, Einstein Medical Center Philadelphia, Philadelphia, USA.

• PMID: 32804317
• PMCID: PMC7429932
• DOI: 10.1007/s00592-020-01592-8

Item in Clipboard

Aims: Coronavirus disease 19 (COVID-19) has become a pandemic. Diabetic patients tend to have poorer outcomes and more severe disease (Kumar et al. in Diabetes Metab Syndr 14(4):535-545, 2020. https://doi.org/10.1016/j.dsx.2020.04.044 ). However, the vast majority of studies are representative of Asian and Caucasian population and fewer represent an African-American population.

Methods: In this single-center, retrospective observational study, we included all adult patients (> 18 years old) admitted to Einstein Medical Center, Philadelphia, with a diagnosis of COVID-19. Patients were classified according to having a known diagnosis of diabetes mellitus. Demographic and clinical data, comorbidities, outcomes and laboratory findings were obtained.

Results: Our sample included a total of 355 patients. 70% were African-American, and 47% had diabetes. Patients with diabetes had higher peak inflammatory markers like CRP 184 (111-258) versus 142 (65-229) p = 0.012 and peak LDH 560 (384-758) versus 499 (324-655) p = 0.017. The need for RRT/HD was significantly higher in patients with diabetes (21% vs 11% p = 0.013) as well as the need for vasopressors (28% vs 18% p = 0.023). Only age was found to be an independent predictor of mortality. We found no significant differences in inpatient mortality p = 0.856, need for RRT/HD p = 0.429, need for intubation p = 1.000 and need for vasopressors p = 0.471 in African-Americans with diabetes when compared to non-African-Americans.

Conclusions: Our study demonstrates that patients with COVID-19 and diabetes tend to have more severe disease and poorer clinical outcomes. African-American patients with diabetes did not differ in outcomes or disease severity when compared to non-African-American patients.

Keywords: COVID-19; Diabetes; Mortality; Novel coronavirus; Outcomes.

PubMed Disclaimer

None of the authors have any conflicts of interest to disclose.

Flow diagram for the study

Flow diagram for the study

Flow diagram for the study

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