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Showing content from https://pubmed.ncbi.nlm.nih.gov/32729142/ below:

COVID-19 outcomes of patients with gynecologic cancer in New York City

Observational Study

. 2020 Oct 1;126(19):4294-4303. doi: 10.1002/cncr.33084. Epub 2020 Jul 30. COVID-19 outcomes of patients with gynecologic cancer in New York City Roisin E O'Cearbhaill², Maria J Smith¹, Megan E Sutter^{1 3}, Anne Knisely⁴, Jennifer McEachron⁵, Lisa R Gabor⁶, Justin Jee², Julia E Fehniger¹, Yi-Chun Lee⁵, Sara S Isani⁶, Jason D Wright⁴, Bhavana Pothuri¹

Affiliations

¹ Department of Obstetrics and Gynecology, Perlmutter Cancer Center, NYU Langone Health, New York, New York.
² Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Population Health, NYU Langone Health, New York, New York.
⁴ Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York.
⁵ Department of Obstetrics and Gynecology, State University of New York Downstate Medical Center, Brooklyn, New York.
⁶ Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.

PMID: 32729142
PMCID: PMC8654115
DOI: 10.1002/cncr.33084

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Observational Study

COVID-19 outcomes of patients with gynecologic cancer in New York City

Olivia D Lara et al. Cancer. 2020.

. 2020 Oct 1;126(19):4294-4303. doi: 10.1002/cncr.33084. Epub 2020 Jul 30. Authors Olivia D Lara¹, Roisin E O'Cearbhaill², Maria J Smith¹, Megan E Sutter^{1 3}, Anne Knisely⁴, Jennifer McEachron⁵, Lisa R Gabor⁶, Justin Jee², Julia E Fehniger¹, Yi-Chun Lee⁵, Sara S Isani⁶, Jason D Wright⁴, Bhavana Pothuri¹ Affiliations

¹ Department of Obstetrics and Gynecology, Perlmutter Cancer Center, NYU Langone Health, New York, New York.
² Department of Medical Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
³ Department of Population Health, NYU Langone Health, New York, New York.
⁴ Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, New York.
⁵ Department of Obstetrics and Gynecology, State University of New York Downstate Medical Center, Brooklyn, New York.
⁶ Department of Obstetrics & Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York.

PMID: 32729142
PMCID: PMC8654115
DOI: 10.1002/cncr.33084

Item in Clipboard

Abstract

Background: New York City (NYC) is the epicenter of severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) in the United States. Clinical characteristics and outcomes of vulnerable populations, such as those with gynecologic cancer who develop COVID-19 infections, is limited.

Methods: Patients from 6 NYC-area hospital systems with known gynecologic cancer and a COVID-19 diagnosis were identified. Demographic and clinical outcome data were abstracted through a review of electronic medical records.

Results: Records for 121 patients with gynecologic cancer and COVID-19 were abstracted; the median age at the COVID-19 diagnosis was 64.0 years (interquartile range, 51.0-73.0 years). Sixty-six of the 121 patients (54.5%) required hospitalization; among the hospitalized patients, 45 (68.2%) required respiratory intervention, 20 (30.3%) were admitted to the intensive care unit, and 9 (13.6%) underwent invasive mechanical ventilation. Seventeen patients (14.0%) died of COVID-19 complications. No patient requiring mechanical ventilation survived. On multivariable analysis, hospitalization was associated with an age ≥64 years (risk ratio [RR], 1.73; 95% confidence interval [CI], 1.18-2.51), African American race (RR, 1.56; 95% CI, 1.13-2.15), and 3 or more comorbidities (RR, 1.43; 95% CI, 1.03-1.98). Only recent immunotherapy use (RR, 3.49; 95% CI, 1.08-11.27) was associated with death due to COVID-19 on multivariable analysis; chemotherapy treatment and recent major surgery were not predictive of COVID-19 severity or mortality.

Conclusions: The case fatality rate among gynecologic oncology patients with a COVID-19 infection is 14.0%. Recent immunotherapy use is associated with an increased risk of mortality related to COVID-19 infection.

Lay summary: The case fatality rate among gynecologic oncology patients with a coronavirus disease 2019 (COVID-19) infection is 14.0%; there is no association between cytotoxic chemotherapy and cancer-directed surgery and COVID-19 severity or death. As such, patients can be counseled regarding the safety of continued anticancer treatments during the pandemic. This is important because the ability to continue cancer therapies for cancer control and cure is critical.

Keywords: coronavirus disease 2019 (COVID-19); gynecologic cancer; outcomes; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

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Figures
Figure 1.

COVID-19 infection and immunotherapy from…

Figure 1.

COVID-19 infection and immunotherapy from individual patients. Baseline (day 0) was the day…

Figure 1.

COVID-19 infection and immunotherapy from individual patients. Baseline (day 0) was the day of last treatment with immunotherapy. For each patient, the colors in the line represent the time before COVID-19 diagnosis, and severity of COVID-19. The dashed lines represent missing data between the patient’s diagnosis of COVID-19 and an event (death, recovery or ongoing infection).