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Showing content from https://pubmed.ncbi.nlm.nih.gov/32320003/ below:

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

. 2020 May 26;323(20):2052-2059. doi: 10.1001/jama.2020.6775. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area Jamie S Hirsch^{1 2 3}, Mangala Narasimhan², James M Crawford², Thomas McGinn^{1 2}, Karina W Davidson^{1 2}; the Northwell COVID-19 Research Consortium; Douglas P Barnaby^{1 2}, Lance B Becker², John D Chelico^{1 2}, Stuart L Cohen^{1 2}, Jennifer Cookingham¹, Kevin Coppa³, Michael A Diefenbach¹, Andrew J Dominello¹, Joan Duer-Hefele¹, Louise Falzon¹, Jordan Gitlin², Negin Hajizadeh^{1 2}, Tiffany G Harvin¹, David A Hirschwerk², Eun Ji Kim^{1 2}, Zachary M Kozel², Lyndonna M Marrast^{1 2}, Jazmin N Mogavero¹, Gabrielle A Osorio¹, Michael Qiu³, Theodoros P Zanos⁴

Affiliations

¹ Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
² Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
³ Department of Information Services, Northwell Health, New Hyde Park, New York.
⁴ Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.

PMID: 32320003
PMCID: PMC7177629
DOI: 10.1001/jama.2020.6775

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Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al. JAMA. 2020.

. 2020 May 26;323(20):2052-2059. doi: 10.1001/jama.2020.6775. Authors Safiya Richardson^{1 2}, Jamie S Hirsch^{1 2 3}, Mangala Narasimhan², James M Crawford², Thomas McGinn^{1 2}, Karina W Davidson^{1 2}; the Northwell COVID-19 Research Consortium; Douglas P Barnaby^{1 2}, Lance B Becker², John D Chelico^{1 2}, Stuart L Cohen^{1 2}, Jennifer Cookingham¹, Kevin Coppa³, Michael A Diefenbach¹, Andrew J Dominello¹, Joan Duer-Hefele¹, Louise Falzon¹, Jordan Gitlin², Negin Hajizadeh^{1 2}, Tiffany G Harvin¹, David A Hirschwerk², Eun Ji Kim^{1 2}, Zachary M Kozel², Lyndonna M Marrast^{1 2}, Jazmin N Mogavero¹, Gabrielle A Osorio¹, Michael Qiu³, Theodoros P Zanos⁴ Affiliations

¹ Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
² Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Northwell Health, Hempstead, New York.
³ Department of Information Services, Northwell Health, New Hyde Park, New York.
⁴ Institute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.

PMID: 32320003
PMCID: PMC7177629
DOI: 10.1001/jama.2020.6775

Item in Clipboard

Erratum in

Clarification of Mortality Rate and Data in Abstract, Results, and Table 2.
[No authors listed] [No authors listed] JAMA. 2020 May 26;323(20):2098. doi: 10.1001/jama.2020.7681. JAMA. 2020. PMID: 32330939 Free PMC article. No abstract available.

Abstract

Importance: There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).

Objective: To describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system.

Design, setting, and participants: Case series of patients with COVID-19 admitted to 12 hospitals in New York City, Long Island, and Westchester County, New York, within the Northwell Health system. The study included all sequentially hospitalized patients between March 1, 2020, and April 4, 2020, inclusive of these dates.

Exposures: Confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample among patients requiring admission.

Main outcomes and measures: Clinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. Demographics, baseline comorbidities, presenting vital signs, and test results were also collected.

Results: A total of 5700 patients were included (median age, 63 years [interquartile range {IQR}, 52-75; range, 0-107 years]; 39.7% female). The most common comorbidities were hypertension (3026; 56.6%), obesity (1737; 41.7%), and diabetes (1808; 33.8%). At triage, 30.7% of patients were febrile, 17.3% had a respiratory rate greater than 24 breaths/min, and 27.8% received supplemental oxygen. The rate of respiratory virus co-infection was 2.1%. Outcomes were assessed for 2634 patients who were discharged or had died at the study end point. During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. As of April 4, 2020, for patients requiring mechanical ventilation (n = 1151, 20.2%), 38 (3.3%) were discharged alive, 282 (24.5%) died, and 831 (72.2%) remained in hospital. The median postdischarge follow-up time was 4.4 days (IQR, 2.2-9.3). A total of 45 patients (2.2%) were readmitted during the study period. The median time to readmission was 3 days (IQR, 1.0-4.5) for readmitted patients. Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1).

Conclusions and relevance: This case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Crawford reported receiving grants from Regeneron outside the submitted work. Dr Becker reported serving on the scientific advisory board for Nihon Kohden and receiving grants from the National Institutes of Health, United Therapeutics, Philips, Zoll, and Patient-Centered Outcomes Research Institute outside the submitted work. Dr Cohen reported receiving personal fees from Infervision outside the submitted work. No other disclosures were reported.

Comment in

Increased mortality among hypertensive COVID-19 patients: Pay a closer look on diuretics in mechanically ventilated patients.
Tsolaki V, Zakynthinos GE, Mantzarlis K, Makris D. Tsolaki V, et al. Heart Lung. 2020 Nov-Dec;49(6):894-895. doi: 10.1016/j.hrtlng.2020.06.009. Epub 2020 Jun 23. Heart Lung. 2020. PMID: 32693957 Free PMC article. No abstract available.
Covid-19: less bronchial airways, more lung alveolar space and blood ways.
Roca E, Lombardi C. Roca E, et al. Eur Ann Allergy Clin Immunol. 2021 Sep;53(5):243-244. doi: 10.23822/EurAnnACI.1764-1489.205. Epub 2021 May 4. Eur Ann Allergy Clin Immunol. 2021. PMID: 33944543 No abstract available.
Are ventilators part of the problem or the solution for COVID-19 mortality?
Leung KKY, Chu S, Hon KLE, Yun Qian S. Leung KKY, et al. Pediatr Pulmonol. 2021 Aug;56(8):2787-2788. doi: 10.1002/ppul.25524. Epub 2021 Jun 10. Pediatr Pulmonol. 2021. PMID: 34111330 No abstract available.