RetroSearch Browse

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/32233013/ below:

Diabetes is a risk factor for the progression and prognosis of COVID-19

doi: 10.1002/dmrr.3319. Epub 2020 Apr 7. Diabetes is a risk factor for the progression and prognosis of COVID-19 Mingyue Li¹, Yalan Dong¹, Haifeng Zhou¹, Zili Zhang¹, Chunxia Tian¹, Renjie Qin¹, Haijun Wang², Yin Shen², Keye Du², Lei Zhao³, Heng Fan¹, Shanshan Luo⁴, Desheng Hu^{1 4}

Affiliations

¹ Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 32233013
PMCID: PMC7228407
DOI: 10.1002/dmrr.3319

Item in Clipboard

Diabetes is a risk factor for the progression and prognosis of COVID-19

Weina Guo et al. Diabetes Metab Res Rev. 2020 Oct.

doi: 10.1002/dmrr.3319. Epub 2020 Apr 7. Authors Weina Guo¹, Mingyue Li¹, Yalan Dong¹, Haifeng Zhou¹, Zili Zhang¹, Chunxia Tian¹, Renjie Qin¹, Haijun Wang², Yin Shen², Keye Du², Lei Zhao³, Heng Fan¹, Shanshan Luo⁴, Desheng Hu^{1 4} Affiliations

¹ Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁴ Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 32233013
PMCID: PMC7228407
DOI: 10.1002/dmrr.3319

Item in Clipboard

Abstract

Backgound: To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).

Methods: A total of 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed.

Results: We found that COVID-19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarkers such as IL-6, C-reactive protein, serum ferritin and coagulation index, D-dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19.

Conclusions: Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.

Keywords: COVID-19; diabetes; prognosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they do not have any conflict of interest regarding this publication.

Figures
FIGURE 1

CT results of the patients…

FIGURE 1

CT results of the patients with diabetes and patients without diabetes. A. The…

FIGURE 1

CT results of the patients with diabetes and patients without diabetes. A. The representative CT images of the patients with diabetes and patients without diabetes. B, The CT score of the patients with diabetes and patients without diabetes. P < .05 was considered statistically significant. CT, computed tomography

FIGURE 2

Biochemical examination results of the…

FIGURE 2

Biochemical examination results of the patients with diabetes and patients without diabetes. P…

FIGURE 2

Biochemical examination results of the patients with diabetes and patients without diabetes. P < .05 was considered statistically significant

FIGURE 3

Other laboratory tests of the…

FIGURE 3

Other laboratory tests of the patients with diabetes and patients without diabetes. A,…

FIGURE 3

Other laboratory tests of the patients with diabetes and patients without diabetes. A, Blood test results of the patients with diabetes and patients without diabetes. B, Inflammation‐related laboratory results of the patients with diabetes and patients without diabetes. C, Coagulation‐related laboratory results of the patients with diabetes and patient without diabetes. P < .05 was considered statistically significant