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Showing content from https://pubmed.ncbi.nlm.nih.gov/32227760/ below:

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

Affiliations

• ¹ From the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).

• PMID: 32227760
• PMCID: PMC7121452
• DOI: 10.1056/NEJMsr2005760

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Muthiah Vaduganathan et al. N Engl J Med. 2020.

• ¹ From the Cardiovascular Division, Brigham and Women's Hospital, and Harvard Medical School, Boston (M.V., T.M., M.A.P., S.D.S.); the Center for Care Delivery and Outcomes Research, Minneapolis VA Health Care System, and University of Minnesota, Minneapolis (O.V.); and the British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom (J.J.V.M.).

• PMID: 32227760
• PMCID: PMC7121452
• DOI: 10.1056/NEJMsr2005760

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No abstract available

PubMed Disclaimer

Shown is the initial entry of…

Shown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker.

• Curcumin as a potential treatment for COVID-19.

  Rocha FAC, de Assis MR. Rocha FAC, et al. Phytother Res. 2020 Sep;34(9):2085-2087. doi: 10.1002/ptr.6745. Epub 2020 Jun 9. Phytother Res. 2020. PMID: 32442323 Free PMC article. No abstract available.

• Cholesterol-modifying drugs in COVID-19.

  Schmidt NM, Wing PAC, McKeating JA, Maini MK. Schmidt NM, et al. Oxf Open Immunol. 2020;1(1):iqaa001. doi: 10.1093/oxfimm/iqaa001. Epub 2020 Jun 18. Oxf Open Immunol. 2020. PMID: 33047740 Free PMC article.

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