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Showing content from https://pubmed.ncbi.nlm.nih.gov/32224151/ below:

Clinical characteristics of COVID-19-infected cancer patients: a retrospective case study in three hospitals within Wuhan, China

Multicenter Study

Affiliations

• ¹ Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ² Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ³ Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• ⁴ Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁵ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁶ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁷ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: minzhou@tjh.tjmu.edu.cn.

• PMID: 32224151
• PMCID: PMC7270947
• DOI: 10.1016/j.annonc.2020.03.296

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Multicenter Study

L Zhang et al. Ann Oncol. 2020 Jul.

• ¹ Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ² Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ³ Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
• ⁴ Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁵ Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁶ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
• ⁷ Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: minzhou@tjh.tjmu.edu.cn.

• PMID: 32224151
• PMCID: PMC7270947
• DOI: 10.1016/j.annonc.2020.03.296

Item in Clipboard

Background: Cancer patients are regarded as a highly vulnerable group in the current Coronavirus Disease 2019 (COVID-19) pandemic. To date, the clinical characteristics of COVID-19-infected cancer patients remain largely unknown.

Patients and methods: In this retrospective cohort study, we included cancer patients with laboratory-confirmed COVID-19 from three designated hospitals in Wuhan, China. Clinical data were collected from medical records from 13 January 2020 to 26 February 2020. Univariate and multivariate analyses were carried out to assess the risk factors associated with severe events defined as a condition requiring admission to an intensive care unit, the use of mechanical ventilation, or death.

Results: A total of 28 COVID-19-infected cancer patients were included; 17 (60.7%) patients were male. Median (interquartile range) age was 65.0 (56.0-70.0) years. Lung cancer was the most frequent cancer type (n = 7; 25.0%). Eight (28.6%) patients were suspected to have hospital-associated transmission. The following clinical features were shown in our cohort: fever (n = 23, 82.1%), dry cough (n = 22, 81%), and dyspnoea (n = 14, 50.0%), along with lymphopaenia (n = 23, 82.1%), high level of high-sensitivity C-reactive protein (n = 23, 82.1%), anaemia (n = 21, 75.0%), and hypoproteinaemia (n = 25, 89.3%). The common chest computed tomography (CT) findings were ground-glass opacity (n = 21, 75.0%) and patchy consolidation (n = 13, 46.3%). A total of 15 (53.6%) patients had severe events and the mortality rate was 28.6%. If the last antitumour treatment was within 14 days, it significantly increased the risk of developing severe events [hazard ratio (HR) = 4.079, 95% confidence interval (CI) 1.086-15.322, P = 0.037]. Furthermore, patchy consolidation on CT on admission was associated with a higher risk of developing severe events (HR = 5.438, 95% CI 1.498-19.748, P = 0.010).

Conclusions: Cancer patients show deteriorating conditions and poor outcomes from the COVID-19 infection. It is recommended that cancer patients receiving antitumour treatments should have vigorous screening for COVID-19 infection and should avoid treatments causing immunosuppression or have their dosages decreased in case of COVID-19 coinfection.

Keywords: COVID-19; cancer; retrospective case study; severe clinical events.

Copyright © 2020 European Society for Medical Oncology. Published by Elsevier Ltd. All rights reserved.

PubMed Disclaimer

Disclosure All authors have declared no conflicts of interest.

Representative images of the chest…

Representative images of the chest computed tomography (CT) scan at different times throughout…

Representative images of the chest computed tomography (CT) scan at different times throughout the disease course. (A–C) Axial CT scanning and (D–F) coronal scanning images are from a 70-year-old woman who was diagnosed with adenocarcinoma and received left upper lobectomy in 2010. As her adenocarcinoma recurred in 2012, she has so far received four courses of chemotherapy and targeted therapy (gefitinib). (A and D) Day 1 after symptom onset: left lung with reduced lung volume after left upper lobectomy and multifocal ground-glass opacities in the bilateral inferior lung lobes (arrows). (B and E) Day 10 after symptom onset: progressively diffused ground-glass opacities and consolidation (arrows) in bilateral subpleural regions. (C and F) Day 25 after symptom onset: improvement of ground-glass opacities and little fibrous stripe in the right lower lung (arrow). (G–I) Coronal CT scanning images are from a 47-year-old man who was diagnosed with nasopharyngeal carcinoma in 2016. Radiotherapy adjuvant chemotherapy was carried out. (G) Day 21 after symptom onset: diffused ground-glass opacities, obvious consolidation, mixed with reticular appearance in bilateral lungs. (H) Day 28 after symptom onset: decreased ground-glass opacity, consolidation, and interlobular septal thickening (arrow). (I) Day 32 after symptom onset: further improvement in appearance with predominant reticular patterns (arrows).

Kaplan–Meier curve of risk factors…

Kaplan–Meier curve of risk factors for developing severe events, adjusted by age and…

Kaplan–Meier curve of risk factors for developing severe events, adjusted by age and sex. (A) Cancer patients who received antitumour treatment within 14 days before Corona Disease 2019 (COVID-19) diagnosis or >14 days after its diagnosis. (B) Patchy consolidation in the first computed tomography scan on admission or its absence on admission.

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  Oh WK. Oh WK. Ann Oncol. 2020 Jul;31(7):838-839. doi: 10.1016/j.annonc.2020.03.297. Epub 2020 Mar 31. Ann Oncol. 2020. PMID: 32243894 Free PMC article. No abstract available.

• Management of hepatocellular carcinoma in the time of COVID-19.

  Iavarone M, Sangiovanni A, Carrafiello G, Rossi G, Lampertico P. Iavarone M, et al. Ann Oncol. 2020 Aug;31(8):1084-1085. doi: 10.1016/j.annonc.2020.04.007. Epub 2020 Apr 21. Ann Oncol. 2020. PMID: 32330540 Free PMC article. No abstract available.

• Call for ensuring cancer care continuity during COVID-19 pandemic.

  Tagliamento M, Lambertini M, Genova C, Barisione E, De Maria A, Grosso M, Poggio F, Vagge S, Boccardo F, Pronzato P, Del Mastro L. Tagliamento M, et al. ESMO Open. 2020 May;5(3):e000783. doi: 10.1136/esmoopen-2020-000783. ESMO Open. 2020. PMID: 32381594 Free PMC article. No abstract available.

• Infection rate and clinical management of cancer patients during the COVID-19 pandemic: experience from a tertiary care hospital in northern Italy.

  Fong D, Rauch S, Petter C, Haspinger E, Alber M, Mitterer M. Fong D, et al. ESMO Open. 2020 Jun;5(3):e000810. doi: 10.1136/esmoopen-2020-000810. ESMO Open. 2020. PMID: 32527730 Free PMC article.

• Covid-19 patients with cancer: what do they risk? Clinical, radiological and therapeutic features.

  Giuliani J, Mantoan B, Bonetti A. Giuliani J, et al. Recenti Prog Med. 2021 Jun;112(6):476-481. doi: 10.1701/3620.36033. Recenti Prog Med. 2021. PMID: 34128942 No abstract available.

• Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2.

  Xu X, Yu C, Qu J, Zhang L, Jiang S, Huang D, Chen B, Zhang Z, Guan W, Ling Z, Jiang R, Hu T, Ding Y, Lin L, Gan Q, Luo L, Tang X, Liu J. Xu X, et al. Eur J Nucl Med Mol Imaging. 2020 May;47(5):1275-1280. doi: 10.1007/s00259-020-04735-9. Epub 2020 Feb 28. Eur J Nucl Med Mol Imaging. 2020. PMID: 32107577 Free PMC article.

• Clinical characteristics and drug therapies in patients with the common-type coronavirus disease 2019 in Hunan, China.

  Huang Q, Deng X, Li Y, Sun X, Chen Q, Xie M, Liu S, Qu H, Liu S, Wang L, He G, Gong Z. Huang Q, et al. Int J Clin Pharm. 2020 Jun;42(3):837-845. doi: 10.1007/s11096-020-01031-2. Epub 2020 May 14. Int J Clin Pharm. 2020. PMID: 32410206 Free PMC article.

• Maternal and infant outcomes of full-term pregnancy combined with COVID-2019 in Wuhan, China: retrospective case series.

  Chen Y, Bai J. Chen Y, et al. Arch Gynecol Obstet. 2020 Sep;302(3):545-551. doi: 10.1007/s00404-020-05573-8. Epub 2020 Jul 21. Arch Gynecol Obstet. 2020. PMID: 32696241 Free PMC article. Review.

• Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

  Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y, Zhao Y, Li Y, Wang X, Peng Z. Wang D, et al. JAMA. 2020 Mar 17;323(11):1061-1069. doi: 10.1001/jama.2020.1585. JAMA. 2020. PMID: 32031570 Free PMC article.

• The COVID-19 Pandemic and its Impact on the Cardio-Oncology Population.

  Asokan I, Rabadia SV, Yang EH. Asokan I, et al. Curr Oncol Rep. 2020 May 28;22(6):60. doi: 10.1007/s11912-020-00945-4. Curr Oncol Rep. 2020. PMID: 32462289 Free PMC article. Review.

• Victoria (Australia) radiotherapy response to working through the first and second wave of COVID-19: Strategies and staffing.

  Rykers K, Tacey M, Bowes J, Brown K, Yuen E, Wilson C, Khor R, Foroudi F. Rykers K, et al. J Med Imaging Radiat Oncol. 2021 Jun;65(3):374-383. doi: 10.1111/1754-9485.13186. Epub 2021 Apr 27. J Med Imaging Radiat Oncol. 2021. PMID: 33908186 Free PMC article.

• Immunotherapy may protect cancer patients from SARS-CoV-2 infection: a single-center retrospective analysis.

  Isgrò MA, Vitale MG, Celentano E, Nocerino F, Porciello G, Curvietto M, Mallardo D, Montagnese C, Russo L, Zanaletti N, Avallone A, Pensabene M, De Laurentiis M, Centonze S, Pignata S, Cannella L, Morabito A, Caponigro F, Botti G, Masucci GV, Giannarelli D, Cavalcanti E, Ascierto PA. Isgrò MA, et al. J Transl Med. 2021 Mar 31;19(1):132. doi: 10.1186/s12967-021-02798-2. J Transl Med. 2021. PMID: 33789686 Free PMC article.

• Comparison of clinical outcomes and risk factors for COVID-19 infection in cancer patients without anticancer treatment and noncancer patients.

  Yang S, Zhao H, Cui R, Ma L, Ge X, Fu Q, Yu D, Niu X. Yang S, et al. Front Public Health. 2022 Aug 12;10:925519. doi: 10.3389/fpubh.2022.925519. eCollection 2022. Front Public Health. 2022. PMID: 36033814 Free PMC article.

• Coronavirus Disease 2019 Presenting as Abdominal Distension in a Mesothelioma Patient: Do We Need to Think Outside the Box?

  Irfan M, Almas T, Ullah I, Tran E, Ali A. Irfan M, et al. Cureus. 2020 Aug 22;12(8):e9947. doi: 10.7759/cureus.9947. Cureus. 2020. PMID: 32983654 Free PMC article.

• Synthesis, characterization, molecular docking, and anticancer activities of new 1,3,4-oxadiazole-5-fluorocytosine hybrid derivatives.

  El Mansouri AE, Lachhab S, Oubella A, Ahmad M, Neyts J, Jochmans D, Chiu W, Vangeel L, De Jonghe S, Morjani H, Ali MA, Zahouily M, Sanghvi YS, Lazrek HB. El Mansouri AE, et al. J Mol Struct. 2022 Sep 9:134135. doi: 10.1016/j.molstruc.2022.134135. Online ahead of print. J Mol Struct. 2022. PMID: 36101881 Free PMC article.

1. 1. Lu H., Stratton C.W., Tang Y.W. Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle. J Med Virol. 2020;92(4):40–42. - PMC - PubMed
2. 1. Zhu N., Zhang D., Wang W. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733. - PMC - PubMed
3. 1. Zhou P., Yang X.L., Wang X.G. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;5791(7798):270–273. - PMC - PubMed
4. 1. Li Q., Guan X., Wu P. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199–1207. - PMC - PubMed
5. 1. Yin Y., Wunderink R.G. MERS, SARS and other coronaviruses as causes of pneumonia. Respirology. 2018;23(2):130–137. - PMC - PubMed

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