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Showing content from https://pubmed.ncbi.nlm.nih.gov/32077115/ below:

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China

Affiliations

• ¹ Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ² Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ³ Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.
• ⁴ Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ⁵ Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China.
• ⁶ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

• PMID: 32077115
• DOI: 10.1111/all.14238

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Jin-Jin Zhang et al. Allergy. 2020 Jul.

• ¹ Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ² Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ³ Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China.
• ⁴ Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
• ⁵ Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China.
• ⁶ Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

• PMID: 32077115
• DOI: 10.1111/all.14238

Item in Clipboard

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2.

Methods: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed.

Results: An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r = .486, P < .001) and nonsevere (r = .469, P < .001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P < .001).

Conclusion: Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients.

Keywords: COVID-19; SARS-CoV-2; allergy; eosinophil; risk factor.

© 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

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