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Showing content from https://pubmed.ncbi.nlm.nih.gov/32062687 below:

Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

. 2020 Jul;31(7):1299-1304. doi: 10.1007/s00198-020-05334-y. Epub 2020 Feb 15. Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

Affiliations

¹ New Mexico Clinical Research & Osteoporosis Center, 300 Oak Street NE, Albuquerque, NM, 87106, USA.
² Optum, 11000 Optum Circle, Eden Prairie, MN, 55344, USA.
³ Radius Health, Inc., 950 Winter Street, Waltham, MA, 02451, USA. swilliams@radiuspharm.com.
⁴ Radius Health, Inc., 950 Winter Street, Waltham, MA, 02451, USA.
⁵ University of Alabama at Birmingham, 510 20th Street South, Faculty Office Towers 802D, Birmingham, AL, 35294, USA.

PMID: 32062687
PMCID: PMC7280339
DOI: 10.1007/s00198-020-05334-y

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Osteoporotic fracture trends in a population of US managed care enrollees from 2007 to 2017

E M Lewiecki et al. Osteoporos Int. 2020 Jul.

. 2020 Jul;31(7):1299-1304. doi: 10.1007/s00198-020-05334-y. Epub 2020 Feb 15. Affiliations

¹ New Mexico Clinical Research & Osteoporosis Center, 300 Oak Street NE, Albuquerque, NM, 87106, USA.
² Optum, 11000 Optum Circle, Eden Prairie, MN, 55344, USA.
³ Radius Health, Inc., 950 Winter Street, Waltham, MA, 02451, USA. swilliams@radiuspharm.com.
⁴ Radius Health, Inc., 950 Winter Street, Waltham, MA, 02451, USA.
⁵ University of Alabama at Birmingham, 510 20th Street South, Faculty Office Towers 802D, Birmingham, AL, 35294, USA.

PMID: 32062687
PMCID: PMC7280339
DOI: 10.1007/s00198-020-05334-y

Item in Clipboard

Abstract

This study expands on previous findings that hip fracture rates may no longer be declining. We found that age- and sex-adjusted fracture rates in the US plateaued or increased through mid-2017 in a population of commercially insured and Medicare Advantage health plan enrollees, in contrast to a decline from 2007 to 2013.

Introduction: The purpose of this study was to evaluate fracture trends in US commercial and Medicare Advantage health plan members aged ≥ 50 years between 2007 and 2017.

Methods: Retrospective analysis of the Optum Research Database from January 1, 2007, to May 31, 2017.

Results: Of 1,841,263 patients identified with an index fracture, 930,690 were case-qualifying and included in this analysis. The overall age- and sex-adjusted fracture rate decreased from 14.67/1000 person-years (py) in 2007 to 11.79/1000 py in 2013, followed by a plateau for the next 3 years and then an increase to 12.50/1000 py in mid-2017. In females aged ≥ 65 years, fracture rates declined from 27.49/1000 py in 2007 to 22.08/1000 py in 2013, then increased to 24.92/1000 py in mid-2017. Likewise, fracture rates in males aged ≥ 65 years declined from 2007 (12.00/1000 py) to 2013 (10.72/1000 py), then increased to 12.04/1000 py in mid-2017. The age- and sex-adjusted fracture rates for most fracture sites declined from 2007 to 2013 by 3.7% per year (P = 0.310).

Conclusions: Following a consistent decline in fracture rate from 2007 to 2013, trends from 2014 to 2017 indicate fracture rates are no longer declining and, for some fracture types, rates are rising.

Keywords: Commercial insurance; Fracture trends; Medicare advantage; Osteoporosis.

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Conflict of interest statement

EML has received no direct income from potentially conflicting entities. His employer, New Mexico Clinical Research & Osteoporosis Center, has received research grants from Radius, Amgen, Mereo BioPharma, and Bindex; income for service on scientific advisory boards or consulting for Amgen, Radius Health Inc., Alexion Pharmaceuticals, Sandoz, and Samsung Bioepis; service on speakers’ bureaus for Radius Health Inc. and Alexion; project development for University of New Mexico; and royalties from UpToDate for sections on DXA, fracture risk assessment, and prevention of osteoporosis. He is a board member of the National Osteoporosis Foundation, International Society for Clinical Densitometry, and Osteoporosis Foundation of New Mexico. BC and KS are employees of Optum, which received funding from Radius Health, Inc., to conduct the study. SAW, RJW, and YW, are employees of and own equity stock in Radius Health, Inc. LAF is a former employee of, is a current consultant, and owns equity stock in Radius Health Inc. JRC is a consultant for Amgen and Radius Health, Inc., and is an employee of the University of Alabama at Birmingham, which has received research grants from Amgen and Radius Health, Inc.

Figures
Fig. 1

Fracture rate per 1000 person-years…

Fig. 1

Fracture rate per 1000 person-years by age and sex which includes fractures of…

Fig. 1

Fracture rate per 1000 person-years by age and sex which includes fractures of the ankle, carpal/wrist, hip, femur, pelvis, radius/ulna, shoulder, spine, tibia/fibia, or multiple sites

Fig. 2

Age- and sex-adjusted fracture rates…

Fig. 2

Age- and sex-adjusted fracture rates per 1000 person-years by fracture site

Fig. 2

Age- and sex-adjusted fracture rates per 1000 person-years by fracture site