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Showing content from https://pubmed.ncbi.nlm.nih.gov/32057315/ below:

Projected time to elimination of cervical cancer in the USA: a comparative modelling study

. 2020 Apr;5(4):e213-e222. doi: 10.1016/S2468-2667(20)30006-2. Epub 2020 Feb 10. Projected time to elimination of cervical cancer in the USA: a comparative modelling study

Affiliations

¹ Harvard T H Chan School of Public Health, Center for Health Decision Science, Boston, MA, USA; Department of Health Management and Health Economics, University of Oslo, Oslo, Norway. Electronic address: eburger@hsph.harvard.edu.
² Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia; School of Public Health, University of Sydney, Sydney, NSW, Australia.
³ Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia.
⁴ Harvard T H Chan School of Public Health, Center for Health Decision Science, Boston, MA, USA.
⁵ Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia; School of Public Health, University of Sydney, Sydney, NSW, Australia; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.

PMID: 32057315
PMCID: PMC8715100
DOI: 10.1016/S2468-2667(20)30006-2

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Projected time to elimination of cervical cancer in the USA: a comparative modelling study

Emily A Burger et al. Lancet Public Health. 2020 Apr.

. 2020 Apr;5(4):e213-e222. doi: 10.1016/S2468-2667(20)30006-2. Epub 2020 Feb 10. Affiliations

¹ Harvard T H Chan School of Public Health, Center for Health Decision Science, Boston, MA, USA; Department of Health Management and Health Economics, University of Oslo, Oslo, Norway. Electronic address: eburger@hsph.harvard.edu.
² Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia; School of Public Health, University of Sydney, Sydney, NSW, Australia.
³ Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia.
⁴ Harvard T H Chan School of Public Health, Center for Health Decision Science, Boston, MA, USA.
⁵ Cancer Research Division, Cancer Council NSW, Sydney NSW, Australia; School of Public Health, University of Sydney, Sydney, NSW, Australia; Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.

PMID: 32057315
PMCID: PMC8715100
DOI: 10.1016/S2468-2667(20)30006-2

Item in Clipboard

Abstract

Background: In May, 2018, the Director-General of WHO issued a global call to eliminate cervical cancer as a public health problem, which will involve ambitious screening and vaccination coverage targets. We aimed to assess the potential for, and timing of, cervical cancer elimination in the USA and whether this could be expedited by adopting ambitious coverage targets, using two cervical cancer simulation models.

Methods: In this modelling study, we used two independently-developed cervical cancer microsimulation models-Harvard and Policy1-Cervix-to estimate changes in the incidence of human papillomavirus (HPV)-induced cervical cancer over time in the USA, including herd effects from vaccination. We compared nine alternative scenarios for prophylactic HPV vaccination and cervical screening scale-up with a status quo scenario that involved no additional interventions in the context of a threshold for cervical cancer elimination of four or fewer cases per 100 000 women-years. We also estimated the number of cervical cancer cases that could be averted between 2019 and 2100 associated with the adoption of ambitious goals for cervical cancer screening and vaccination coverage, and other potential strategies.

Findings: Under status quo assumptions, the Havard and Policy1-Cervix models projected that cervical cancer incidence would decrease to less than four or fewer new cases per 100 000 women-years by the 2038 and 2046, respectively. Scaling up screening coverage to 90% in 2020, was the most effective intervention to expedite time to elimination (10-13-year reduction), averting a mean of 1400-2088 additional cases annually between 2019 and 2100. Increasing HPV vaccination coverage to 90% or vaccinating adults aged 26-45 years had relatively little effect on cervical cancer incidence. Sensitivity analysis using different population structures resulted in differences in time to elimination (range -10 years to +27 years) compared with status quo predictions.

Interpretation: The USA is on track to eliminate cervical cancer as a public health problem in the next two to three decades. Time to elimination could be expedited by 10-13 years by achieving higher screening coverage. Targeting of underscreened and under-vaccinated women remains key to achieving cervical cancer elimination for all women.

Funding: US National Cancer Institute.

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Figures
Figure 1.. Age-standardized (U.S. 2000 Population ages…

Figure 1.. Age-standardized (U.S. 2000 Population ages 0–99 years) incidence per 100,000 women under ‘status…
Figure 1.. Age-standardized (U.S. 2000 Population ages 0–99 years) incidence per 100,000 women under ‘status quo’ and two high-coverage screening and vaccination scenarios for two CISNET-Cervical disease simulation models.

‘Status quo’ screening involved 3-yearly cytology screening in women aged 21–65 years with management according to established guidelines. Screening practice was based on empirical lab-based data from the New Mexico HPV Pap Registry. Age- and sex-specific HPV vaccination coverage was based on NIS-TEEN interviews, including historical vaccination coverage using the quadrivalent vaccine starting in 2007 for girls and 2010 for boys and the nonavalent HPV vaccine from 2015 onwards, based on updated U.S. guidelines (Appendix Section 3). Vaccination was assumed to provide 95% lifelong protection against incident HPV infections targeted by the vaccines. The “sawtooth” pattern associated with the screening coverage scale-up scenarios reflect the detection of prevalent preclinical cancers among the under- and over-screeners converging to a 3-yearly interval in the year 2020.

Figure 2.. Projections in annual number of…

Figure 2.. Projections in annual number of cervical cancer cases averted for alternative screening and…
Figure 2.. Projections in annual number of cervical cancer cases averted for alternative screening and human papillomavirus (HPV) assumptions compared with ‘status quo’ screening and vaccination assumptions for two CISNET-Cervical disease simulation models.

‘Status quo’ screening involved 3-yearly cytology screening in women aged 21–65 years with management according to established guidelines. Screening practice was based on empirical lab-based data from the New Mexico HPV Pap Registry. Age- and sex-specific HPV vaccination coverage was based on NIS-TEEN interviews, including historical vaccination coverage using the quadrivalent vaccine starting in 2007 for girls and 2010 for boys and the nonavalent HPV vaccine from 2015 onwards, based on updated U.S. guidelines (Appendix Section 3). Vaccination was assumed to provide 95% lifelong protection against incident HPV infections targeted by the vaccines. See Table 1 for alternative cervical cancer control strategies and assumptions. The “sawtooth” pattern associated with the screening coverage scale-up scenarios reflect the detection of prevalent preclinical cancers among the under- and over-screeners converging to a 3-yearly interval in the year 2020. “Negative” averted cancer cases stem from earlier detection of preclinical cancers when screening coverage is scaled-up.