Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/31767364/ below:

Outcome of delayed versus timely esophagectomy after chemoradiation for esophageal adenocarcinoma

Comparative Study

Collaborators, Affiliations

• Cincinnati Research in Outcomes and Safety in Surgery (CROSS) Group:

• ¹ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ² Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ³ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ⁴ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: vanharrm@ucmail.uc.edu.

• PMID: 31767364
• DOI: 10.1016/j.jtcvs.2019.09.169

Item in Clipboard

Comparative Study

Nick C Levinsky et al. J Thorac Cardiovasc Surg. 2020 Jun.

• Cincinnati Research in Outcomes and Safety in Surgery (CROSS) Group:

• ¹ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ² Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Surgical Oncology, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ³ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
• ⁴ Cincinnati Research in Outcomes and Safety in Surgery (CROSS), Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address: vanharrm@ucmail.uc.edu.

• PMID: 31767364
• DOI: 10.1016/j.jtcvs.2019.09.169

Item in Clipboard

Background: Salvage and delayed esophagectomy after chemoradiation therapy (CRT) have been associated with increased morbidity and mortality, but recent series have shown similar outcomes compared to timely esophagectomy. We aim to evaluate outcomes for delayed and salvage esophagectomy for esophageal adenocarcinoma utilizing a large national database.

Methods: The National Cancer Database for 2004 to 2014 was queried for patients with clinical stage II or III esophageal adenocarcinoma who underwent preoperative CRT and esophagectomy. Patients who underwent surgery <90 days after CRT were defined as the timely esophagectomy group (n = 7822), and those who underwent surgery ≥90 days after CRT were defined as the delayed esophagectomy group (n = 667).

Results: A total of 8489 patients met our inclusion criteria. The median post-CRT interval was 49 days (range, 40-61 days) for the timely esophagectomy group and 109 days (range, 97-132 days) for the delayed esophagectomy group. The delayed group was more likely to be of black race (2.3% vs 1.2%; P < .01) and more likely to have Medicare (47.9% vs 39.8%; P < .001). There were no significant between-group differences in chemotherapy regimens (P = .17), radiation dose (P = .18), or surgical approach (P = .48). The delayed esophagectomy group had higher rates of pathological complete response (22.2% vs 18.6%; P = .043) and 90-day postoperative mortality (10.4% vs 7.8%; P < .01). On multivariate analysis, delayed esophagectomy was not independently associated with decreased overall survival.

Conclusions: In this large retrospective database study, despite increased perioperative mortality, delayed and salvage esophagectomy for adenocarcinoma appear to have similar long-term survival as timely esophagectomy. Delayed and salvage esophagectomy may be offered to patients who do not receive timely esophagectomy after CRT.

Keywords: chemoradiation; esophageal cancer; esophagectomy.

Copyright © 2019 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

PubMed Disclaimer

• Prognostic value of neoadjuvant treatment response in locally advanced esophageal adenocarcinoma.

  Groth SS, Burt BM, Farjah F, Smaglo BG, Sada YH, Sugarbaker DJ, Massarweh NN. Groth SS, et al. J Thorac Cardiovasc Surg. 2019 Apr;157(4):1682-1693.e1. doi: 10.1016/j.jtcvs.2018.11.131. Epub 2018 Dec 15. J Thorac Cardiovasc Surg. 2019. PMID: 30711279

• Safety and feasibility of esophagectomy following combined immunotherapy and chemoradiotherapy for esophageal cancer.

  Sihag S, Ku GY, Tan KS, Nussenzweig S, Wu A, Janjigian YY, Jones DR, Molena D. Sihag S, et al. J Thorac Cardiovasc Surg. 2021 Mar;161(3):836-843.e1. doi: 10.1016/j.jtcvs.2020.11.106. Epub 2020 Dec 17. J Thorac Cardiovasc Surg. 2021. PMID: 33485662 Free PMC article.

• Salvage esophagectomy after failed definitive chemoradiation for esophageal adenocarcinoma.

  Marks JL, Hofstetter W, Correa AM, Mehran RJ, Rice D, Roth J, Walsh G, Vaporciyan A, Erasmus J, Chang J, Maru D, Lee JH, Lee J, Ajani JA, Swisher SG. Marks JL, et al. Ann Thorac Surg. 2012 Oct;94(4):1126-32; discussion 1132-3. doi: 10.1016/j.athoracsur.2012.05.106. Epub 2012 Aug 24. Ann Thorac Surg. 2012. PMID: 22921233

• Esophagectomy after chemoradiation: who and when to operate.

  Kim JY, Hofstetter WL. Kim JY, et al. Semin Thorac Cardiovasc Surg. 2012 Winter;24(4):288-93. doi: 10.1053/j.semtcvs.2012.10.005. Semin Thorac Cardiovasc Surg. 2012. PMID: 23465677 Review.

• Systematic review and meta-analysis on the significance of salvage esophagectomy for persistent or recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy.

  Kumagai K, Mariosa D, Tsai JA, Nilsson M, Ye W, Lundell L, Rouvelas I. Kumagai K, et al. Dis Esophagus. 2016 Oct;29(7):734-739. doi: 10.1111/dote.12399. Epub 2015 Aug 28. Dis Esophagus. 2016. PMID: 26316181 Review.

• The Key Clinical Questions of Neoadjuvant Chemoradiotherapy for Resectable Esophageal Cancer-A Review.

  Han D, Li B, Zhao Q, Sun H, Dong J, Hao S, Huang W. Han D, et al. Front Oncol. 2022 Jul 14;12:890688. doi: 10.3389/fonc.2022.890688. eCollection 2022. Front Oncol. 2022. PMID: 35912182 Free PMC article. Review.

• Does the time interval from neoadjuvant camrelizumab combined with chemotherapy to surgery affect outcomes for locally advanced esophageal squamous cell carcinoma?

  Liu J, Zhu L, Huang X, Lu Z, Wang Y, Yang Y, Ye J, Gu C, Lv W, Zhang C, Hu J. Liu J, et al. J Cancer Res Clin Oncol. 2024 Mar 27;150(3):161. doi: 10.1007/s00432-024-05696-4. J Cancer Res Clin Oncol. 2024. PMID: 38536527 Free PMC article.

• COVID-19 Guidance for Triage of Operations for Thoracic Malignancies: A Consensus Statement From Thoracic Surgery Outcomes Research Network.

  Thoracic Surgery Outcomes Research Network, Inc; Antonoff M, Backhus L, Boffa DJ, Broderick SR, Brown LM, Carrott P, Clark JM, Cooke D, David E, Facktor M, Farjah F, Grogan E, Isbell J, Jones DR, Kidane B, Kim AW, Keshavjee S, Krantz S, Lui N, Martin L, Meguid RA, Meyerson SL, Mullett T, Nelson H, Odell DD, Phillips JD, Puri V, Rusch V, Shulman L, Varghese TK, Wakeam E, Wood DE. Thoracic Surgery Outcomes Research Network, Inc, et al. Ann Thorac Surg. 2020 Aug;110(2):692-696. doi: 10.1016/j.athoracsur.2020.03.005. Epub 2020 Apr 9. Ann Thorac Surg. 2020. PMID: 32278755 Free PMC article.

• COVID-19 guidance for triage of operations for thoracic malignancies: A consensus statement from Thoracic Surgery Outcomes Research Network.

  Thoracic Surgery Outcomes Research Network, Inc; Antonoff M, Backhus L, Boffa DJ, Broderick SR, Brown LM, Carrott P, Clark JM, Cooke D, David E, Facktor M, Farjah F, Grogan E, Isbell J, Jones DR, Kidane B, Kim AW, Keshavjee S, Krantz S, Lui N, Martin L, Meguid RA, Meyerson SL, Mullett T, Nelson H, Odell DD, Phillips JD, Puri V, Rusch V, Shulman L, Varghese TK, Wakeam E, Wood DE. Thoracic Surgery Outcomes Research Network, Inc, et al. J Thorac Cardiovasc Surg. 2020 Aug;160(2):601-605. doi: 10.1016/j.jtcvs.2020.03.061. Epub 2020 Apr 9. J Thorac Cardiovasc Surg. 2020. PMID: 32689703 Free PMC article.

• [Surgical treatment of esophageal cancer-Indicators for quality in diagnostics and treatment].

  Hoeppner J, Plum PS, Buhr H, Gockel I, Lorenz D, Ghadimi M, Bruns C; Qualitätskommission der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie. Hoeppner J, et al. Chirurg. 2021 Apr;92(4):350-360. doi: 10.1007/s00104-020-01267-8. Chirurg. 2021. PMID: 32876700 Free PMC article. German.

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3