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Showing content from https://pubmed.ncbi.nlm.nih.gov/31282032/ below:

Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014

. 2019 Oct 1;125(19):3412-3417. doi: 10.1002/cncr.32207. Epub 2019 Jul 8. Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014

Affiliations

¹ Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia.
² Department of Health Management and Policy, School of Public Health, Georgia State University, Atlanta, Georgia.
³ Statistics and Data Management, Cancer Information and Population Health Resource, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

PMID: 31282032
PMCID: PMC6744285
DOI: 10.1002/cncr.32207

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Update on triple-negative breast cancer disparities for the United States: A population-based study from the United States Cancer Statistics database, 2010 through 2014

Lia C Scott et al. Cancer. 2019.

. 2019 Oct 1;125(19):3412-3417. doi: 10.1002/cncr.32207. Epub 2019 Jul 8. Affiliations

¹ Division of Epidemiology and Biostatistics, School of Public Health, Georgia State University, Atlanta, Georgia.
² Department of Health Management and Policy, School of Public Health, Georgia State University, Atlanta, Georgia.
³ Statistics and Data Management, Cancer Information and Population Health Resource, Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

PMID: 31282032
PMCID: PMC6744285
DOI: 10.1002/cncr.32207

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Abstract

Background: Triple-negative breast cancer (TNBC) has been associated with a more aggressive histology, poorer prognosis, and nonresponsiveness to hormone therapy. It is imperative that cancer research identify factors that drive disparities and focus on prevention.

Methods: Using the United States Cancer Statistics database, the authors examined differences between TNBCs compared with all other breast cancers with regard to age, race/ethnicity, and stage at diagnosis.

Results: A total of 1,151,724 cases of breast cancer were identified from 2010 through 2014, with the triple-negative phenotype accounting for approximately 8.4% of all cases. In unadjusted analyses, non-Hispanic black women (odds ratio [OR], 2.27; 95% CI, 2.23-2.31) and Hispanic women (OR, 1.22; 95% CI, 1.19-1.25) had higher odds of diagnosis when compared with non-Hispanic white women. Women aged <40 years had the highest odds of diagnosis compared with women aged 50 to 64 years (OR, 1.95; 95% CI, 1.90-2.01). Diagnosis at American Joint Committee on Cancer stage III and beyond conferred higher odds of the diagnosis of TNBC (OR for stage III, 1.69 [95% CI, 1.68-1.72]; and OR for stage IV, 1.47 [95% CI, 1.43-1.51]). Results varied slightly in adjusted analyses.

Conclusions: The results of the current study demonstrated that there is a significant burden of disease in TNBC diagnosed among women of color, specifically non-Hispanic black women, and younger women. Additional studies are needed to determine drivers of disparities between race, age, and stage of disease at diagnosis.

Keywords: continental population groups; epidemiology; ethnic groups; health status disparities; registries; triple-negative breast neoplasms.

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Conflict of interest statement

Conflict of Interest: The authors made no disclosures.