Age-standardized, delay-adjusted incidence rates, and fixed-interval trends (2011–2015) for most common cancers, ages 20–49 years by sex, for areas in the United States with high-quality incidence data. AAPC = 5-year average annual percent change; CI = confidence interval; CNS = central nervous system; NOS = not otherwise specified; ONS = other nervous system. §Rates are per 100 000 persons and were age-standardized to the 2000 US standard population (19 age groups, Census P25–1130) and delay-adjusted. ¥Counts in parentheses after the bars are the delay-adjusted counts observed in the 48 registries with high-quality data for 2015. AAPC is a weighted average of the APCs over the fixed interval 2011–2015 using the underlying joinpoint model for the period 1999–2015, except for breast (in situ), which used the period 2001–2015, and nonmalignant brain, which used the period 2008–2015. The maximum number of joinpoints was based on the length of the time period: three for the period 1999–2015, two for the period 2001–2015 (in situ breast cancer), and one for the period 2008–2015 (nonmalignant CNS tumors). For joinpoint analyses, the Joinpoint Regression Program was used (version 4.6.0.0), Bethesda, MD: Statistical Research and Applications Branch, National Cancer Institute; April 2018. Registries included in the joinpoint models (1999–2015) for invasive cancers (41 states): Alabama, Alaska, Arizona, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, Texas, Utah, Vermont, Washington, West Virginia, Wisconsin, and Wyoming. Registries included in rates for invasive cancers (2011–2015) (47 states and 1 territory): Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming, and Puerto Rico. Registries included in the joinpoint models (2001–2015) for breast in situ (43 states covering 87.6% of the population of the United States and Puerto Rico): Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Texas, Utah, Vermont, Washington, West Virginia, Wisconsin, Wyoming. Registries included in the joinpoint models (2008–2015) for nonmalignant CNS tumors (46 states and 1 territory covering 97.5% of the population of the United States and Puerto Rico): Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, Montana, Nebraska, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, Wyoming, and Puerto Rico.
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