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Showing content from https://pubmed.ncbi.nlm.nih.gov/31015201/ below:

Predictive Value of HPV Testing in Self-collected and Clinician-Collected Samples Compared with Cytology in Detecting High-grade Cervical Lesions

Affiliations

• ¹ Division of Cancer Epidemiology, McGill University, Montreal, Canada. mariam.elzein@mcgill.ca.
• ² Division of Cancer Epidemiology, McGill University, Montreal, Canada.
• ³ Gynecologic Cancer Service, McGill University Health Centre - Glen Site Cedars Cancer Centre, Montreal, Canada.
• ⁴ Division of Gynecologic Oncology and Colposcopy, McGill University - Jewish General Hospital, Montreal, Canada.
• ⁵ Department of Obstetrics and Gynecology, McGill University Health Centre - St. Mary's Hospital Centre, Montreal, Canada.
• ⁶ Department of Microbiology, McGill University Health Centre, Montreal, Canada.

• PMID: 31015201
• DOI: 10.1158/1055-9965.EPI-18-1338

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Mariam El-Zein et al. Cancer Epidemiol Biomarkers Prev. 2019 Jul.

• ¹ Division of Cancer Epidemiology, McGill University, Montreal, Canada. mariam.elzein@mcgill.ca.
• ² Division of Cancer Epidemiology, McGill University, Montreal, Canada.
• ³ Gynecologic Cancer Service, McGill University Health Centre - Glen Site Cedars Cancer Centre, Montreal, Canada.
• ⁴ Division of Gynecologic Oncology and Colposcopy, McGill University - Jewish General Hospital, Montreal, Canada.
• ⁵ Department of Obstetrics and Gynecology, McGill University Health Centre - St. Mary's Hospital Centre, Montreal, Canada.
• ⁶ Department of Microbiology, McGill University Health Centre, Montreal, Canada.

• PMID: 31015201
• DOI: 10.1158/1055-9965.EPI-18-1338

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Background: Self-sampling has become an attractive proposition now that human papillomavirus (HPV) primary testing is being incorporated into cervical cancer screening programs worldwide. We compared predictive values of HPV testing based on self- and physician-collected samples, and cytology, in detecting high-grade cervical intraepithelial neoplasia (CIN).

Methods: The Cervical And Self-Sample In Screening (CASSIS) study enrolled 1,217 women ages 16-70 years prior to scheduled colposcopies. Vaginal specimens were self-collected using the validated HerSwab device. Cervical specimens were collected by gynecologists. Specimens were tested for presence of high-risk HPV (hrHPV) by the Cobas 4800 HPV test. We estimated positive predictive values (PPV) and negative predictive values (NPV) and 95% confidence intervals (CI) for a subset of women (n = 700) who underwent cervical biopsy and cytology at the actual CASSIS visit.

Results: hrHPV was detected in 329 women (47%) with HerSwab and in 327 (46.7%) with physician sampling. Respective values for HPV16/18 were 119 (17%) and 121 (17.3%). On histology, 134 women had CIN1, 49 had CIN2, 48 had CIN3, 5 had CIN2/CIN3, and 3 had cancers. PPVs for CIN2⁺ of any hrHPV were 28% (95% CI, 23.2-33.1) and 29.7% (95% CI, 24.8-34.9) for HerSwab and physician samples, respectively. Corresponding values for HPV16/18 were 43.7% (95% CI, 34.6-53.1) and 43.8% (95% CI, 34.8-53.1). PPV of cytology (ASC-US+) was 26.6% (95% CI, 21.6-32.0). Corresponding NPVs (same order as PPVs) were 96.4% (95% CI, 93.9-98.1), 97.8% (95% CI, 95.6-99), 90.9% (95% CI, 88.2-93.1), 91% (95% CI, 88.4-93.2), and 94.7% (95% CI, 91.8-96.8).

Conclusions: Our results confirm that HPV self-sampling has comparable performance with a physician-collected sample in detecting cervical lesions.

Impact: HPV self-sampling has the potential to increase coverage in cervical cancer screening.

©2019 American Association for Cancer Research.

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• Validation of a new HPV self-sampling device for cervical cancer screening: The Cervical and Self-Sample In Screening (CASSIS) study.

  El-Zein M, Bouten S, Louvanto K, Gilbert L, Gotlieb W, Hemmings R, Behr MA, Franco EL; CASSIS Study Group. El-Zein M, et al. Gynecol Oncol. 2018 Jun;149(3):491-497. doi: 10.1016/j.ygyno.2018.04.004. Epub 2018 Apr 17. Gynecol Oncol. 2018. PMID: 29678360 Clinical Trial.

• Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study.

  Castle PE, Stoler MH, Wright TC Jr, Sharma A, Wright TL, Behrens CM. Castle PE, et al. Lancet Oncol. 2011 Sep;12(9):880-90. doi: 10.1016/S1470-2045(11)70188-7. Epub 2011 Aug 22. Lancet Oncol. 2011. PMID: 21865084 Clinical Trial.

• Comparison of different strategies for the triage to colposcopy of women tested high-risk HPV positive on self-collected cervicovaginal samples.

  Chatzistamatiou K, Tsertanidou A, Moysiadis T, Mouchtaropoulou E, Pasentsis K, Skenderi A, Stamatopoulos K, Agorastos T. Chatzistamatiou K, et al. Gynecol Oncol. 2021 Sep;162(3):560-568. doi: 10.1016/j.ygyno.2021.06.020. Epub 2021 Jun 29. Gynecol Oncol. 2021. PMID: 34210517

• High-risk HPV testing on self-sampled versus clinician-collected specimens: a review on the clinical accuracy and impact on population attendance in cervical cancer screening.

  Snijders PJ, Verhoef VM, Arbyn M, Ogilvie G, Minozzi S, Banzi R, van Kemenade FJ, Heideman DA, Meijer CJ. Snijders PJ, et al. Int J Cancer. 2013 May 15;132(10):2223-36. doi: 10.1002/ijc.27790. Epub 2012 Sep 14. Int J Cancer. 2013. PMID: 22907569 Review.

• HPV testing and monitoring of women after treatment of CIN 3: review of the literature and meta-analysis.

  Zielinski GD, Bais AG, Helmerhorst TJ, Verheijen RH, de Schipper FA, Snijders PJ, Voorhorst FJ, van Kemenade FJ, Rozendaal L, Meijer CJ. Zielinski GD, et al. Obstet Gynecol Surv. 2004 Jul;59(7):543-53. doi: 10.1097/00006254-200407000-00024. Obstet Gynecol Surv. 2004. PMID: 15199273 Review.

• Accelerating action on cervical screening in lower- and middle-income countries (LMICs) post COVID-19 era.

  Woo YL, Gravitt P, Khor SK, Ng CW, Saville M. Woo YL, et al. Prev Med. 2021 Mar;144:106294. doi: 10.1016/j.ypmed.2020.106294. Epub 2021 Mar 4. Prev Med. 2021. PMID: 33678225 Free PMC article.

• Prevalence and Risk Factors of Human Papillomavirus Infection among Japanese Female People: A Nationwide Epidemiological Survey by Self-Sampling.

  Kitamura T, Suzuki M, Shigehara K, Fukuda K. Kitamura T, et al. Asian Pac J Cancer Prev. 2021 Jun 1;22(6):1843-1849. doi: 10.31557/APJCP.2021.22.6.1843. Asian Pac J Cancer Prev. 2021. PMID: 34181341 Free PMC article.

• A New Brazilian Device for Cervical Cancer Screening: Acceptability and Accuracy of Self-sampling.

  Lichtenfels M, Lorenzi NPC, Tacla M, Yokochi K, Frustockl F, Silva CA, Silva ALD, Termini L, Farias CB. Lichtenfels M, et al. Rev Bras Ginecol Obstet. 2023 May;45(5):235-241. doi: 10.1055/s-0043-1770134. Epub 2023 Jun 20. Rev Bras Ginecol Obstet. 2023. PMID: 37339642 Free PMC article.

• Evaluation of a novel vaginal cells self-sampling device for human papillomavirus testing in cervical cancer screening: A clinical trial assessing reliability and acceptability.

  Yang CY, Chang TC, Chou HH, Chao A, Hsu ST, Shih YH, Huang HJ, Lin CT, Chen MY, Sun L, Huang KG, Wu KY, Hsieh WC, Huang YT, Chen LH, Lu CH, Lin H, Cheng CM. Yang CY, et al. Bioeng Transl Med. 2024 Mar 13;9(4):e10653. doi: 10.1002/btm2.10653. eCollection 2024 Jul. Bioeng Transl Med. 2024. PMID: 39036090 Free PMC article.

• [Cancer prevention recommendations: Update 2024].

  Bartolomé-Moreno C, Melús-Palazón E, Vela-Vallespín C, Arana-Ballestar S, Gallego M, Navarro J, Bellas-Beceiro B; Grupos de expertos del PAPPS. Bartolomé-Moreno C, et al. Aten Primaria. 2024 Nov;56 Suppl 1(Suppl 1):103128. doi: 10.1016/j.aprim.2024.103128. Aten Primaria. 2024. PMID: 39613364 Free PMC article. Spanish.

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