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Showing content from https://pubmed.ncbi.nlm.nih.gov/30166274/ below:

A Personalized Physical Activity Program With Activity Trackers and a Mobile Phone App for Patients With Metastatic Breast Cancer: Protocol for a Single-Arm Feasibility Trial

. 2018 Aug 30;7(8):e10487. doi: 10.2196/10487. A Personalized Physical Activity Program With Activity Trackers and a Mobile Phone App for Patients With Metastatic Breast Cancer: Protocol for a Single-Arm Feasibility Trial Olivia Pérol¹, Béatrice Fervers^{1 3}, Christine Friedenreich^{4 5}, Jeff Vallance⁶, Olivia Febvey-Combes⁷, David Pérol⁷, Brice Canada⁸, Eva Roitmann⁹, Armelle Dufresne¹⁰, Thomas Bachelot¹⁰, Pierre-Etienne Heudel¹⁰, Olivier Trédan¹⁰, Marina Touillaud^{1 3}, Vincent Pialoux^{2 11}

Affiliations

¹ Department of Cancer and Environment, Léon Bérard Cancer Center, Lyon, France.
² Inter-University Laboratory of Human Movement Biology, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
³ Inserm U1052, Cancer Research Center of Lyon, Léon Bérard Cancer Center, Lyon, France.
⁴ Alberta Health Services, Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Calgary, AB, Canada.
⁵ Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
⁶ Faculty of Health Disciplines, Athabasca University, Athabasca, AB, Canada.
⁷ Department of Clinical Research and Innovation, Léon Bérard Cancer Center, Lyon, France.
⁸ Laboratory on Vulnerabilities and Innovations in Sport, University Claude Bernard Lyon 1, University of Lyon, Villeurbanne, France.
⁹ Digital Health, Data and Studies Department, Nokia Technologies, Issy-Les-Moulineaux, France.
¹⁰ Department of Medical Oncology, Léon Bérard Cancer Center, Lyon, France.
¹¹ Institut Universitaire de France, Paris, France.

PMID: 30166274
PMCID: PMC6137283
DOI: 10.2196/10487

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A Personalized Physical Activity Program With Activity Trackers and a Mobile Phone App for Patients With Metastatic Breast Cancer: Protocol for a Single-Arm Feasibility Trial

Lidia Delrieu et al. JMIR Res Protoc. 2018.

. 2018 Aug 30;7(8):e10487. doi: 10.2196/10487. Authors Lidia Delrieu^#^{1 2}, Olivia Pérol¹, Béatrice Fervers^{1 3}, Christine Friedenreich^{4 5}, Jeff Vallance⁶, Olivia Febvey-Combes⁷, David Pérol⁷, Brice Canada⁸, Eva Roitmann⁹, Armelle Dufresne¹⁰, Thomas Bachelot¹⁰, Pierre-Etienne Heudel¹⁰, Olivier Trédan¹⁰, Marina Touillaud^{1 3}, Vincent Pialoux^{2 11} Affiliations

¹ Department of Cancer and Environment, Léon Bérard Cancer Center, Lyon, France.
² Inter-University Laboratory of Human Movement Biology, University Claude Bernard Lyon 1, University of Lyon, Lyon, France.
³ Inserm U1052, Cancer Research Center of Lyon, Léon Bérard Cancer Center, Lyon, France.
⁴ Alberta Health Services, Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Calgary, AB, Canada.
⁵ Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
⁶ Faculty of Health Disciplines, Athabasca University, Athabasca, AB, Canada.
⁷ Department of Clinical Research and Innovation, Léon Bérard Cancer Center, Lyon, France.
⁸ Laboratory on Vulnerabilities and Innovations in Sport, University Claude Bernard Lyon 1, University of Lyon, Villeurbanne, France.
⁹ Digital Health, Data and Studies Department, Nokia Technologies, Issy-Les-Moulineaux, France.
¹⁰ Department of Medical Oncology, Léon Bérard Cancer Center, Lyon, France.
¹¹ Institut Universitaire de France, Paris, France.

PMID: 30166274
PMCID: PMC6137283
DOI: 10.2196/10487

Item in Clipboard

Abstract

Background: About 5% of breast cancer cases are metastatic at diagnosis, and 20%-30% of localized breast cancer cases become secondarily metastatic. Patients frequently report many detrimental symptoms related to metastasis and treatments. The physical, biological, psychological, and clinical benefits of physical activity during treatment in patients with localized breast cancer have been demonstrated; however, limited literature exists regarding physical activity and physical activity behavior change in patients with metastatic breast cancer.

Objective: The primary objective of this study is to assess the feasibility of a 6-month physical activity intervention with activity trackers in patients with metastatic breast cancer (the Advanced stage Breast cancer and Lifestyle Exercise, ABLE Trial). Secondary objectives are to examine the effects of physical activity on physical, psychological, anthropometrics, clinical, and biological parameters.

Methods: We plan to conduct a single-center, single-arm trial with 60 patients who are newly diagnosed with metastatic breast cancer. Patients will receive an unsupervised and personalized 6-month physical activity program that includes an activity tracker Nokia Go and is based on the physical activity recommendation. Patients will be encouraged to accumulate at least 150 minutes per week of moderate-to-vigorous intensity physical activity. Baseline and 6-month assessments will include anthropometric measures, functional tests (eg, 6-minute walk test and upper and lower limb strength), blood draws, patient-reported surveys (eg, quality of life and fatigue), and clinical markers of tumor progression (eg, Response Evaluation Criteria In Solid Tumors criteria).

Results: Data collection occurred between October 2016 and January 2018, and the results are expected in August 2018.

Conclusions: The ABLE Trial will be the first study to assess the feasibility and effectiveness of an unsupervised and personalized physical activity intervention performed under real-life conditions with activity trackers in patients with metastatic breast cancer.

Trial registration: ClinicalTrials.gov NCT03148886; https://clinicaltrials.gov/ct2/show/NCT03148886 (Accessed by WebCite at http://www.webcitation.org/71yabi0la).

Registered report identifier: RR1-10.2196/10487.

Keywords: activity trackers; feasibility; metastatic breast cancer; oxidative stress; physical activity.

©Lidia Delrieu, Olivia Pérol, Béatrice Fervers, Christine Friedenreich, Jeff Vallance, Olivia Febvey-Combes, David Pérol, Brice Canada, Eva Roitmann, Armelle Dufresne, Thomas Bachelot, Pierre-Etienne Heudel, Olivier Trédan, Marina Touillaud, Vincent Pialoux. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 30.08.2018.

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Conflict of interest statement

Conflicts of Interest: None declared.

Figures
Figure 1

Participant flow chart for the…

Figure 1

Participant flow chart for the Advanced stage Breast cancer Lifestyle and Exercise study,…

Figure 1

Participant flow chart for the Advanced stage Breast cancer Lifestyle and Exercise study, Lyon, France (PA: Physical activity).