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Showing content from https://pubmed.ncbi.nlm.nih.gov/30155605/ below:

Colorectal cancer incidence among Hispanics and non-Hispanic Whites in the United States

. 2018 Nov;29(11):1039-1046. doi: 10.1007/s10552-018-1077-1. Epub 2018 Aug 28. Colorectal cancer incidence among Hispanics and non-Hispanic Whites in the United States

Affiliations

¹ Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA.
³ Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. caitlin.murphy@utsouthwestern.edu.
⁴ Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA. caitlin.murphy@utsouthwestern.edu.
⁵ Division of Epidemiology, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA. caitlin.murphy@utsouthwestern.edu.

PMID: 30155605
PMCID: PMC6628724
DOI: 10.1007/s10552-018-1077-1

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Colorectal cancer incidence among Hispanics and non-Hispanic Whites in the United States

Sandra Garcia et al. Cancer Causes Control. 2018 Nov.

. 2018 Nov;29(11):1039-1046. doi: 10.1007/s10552-018-1077-1. Epub 2018 Aug 28. Affiliations

¹ Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA.
³ Departments of Clinical Sciences and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. caitlin.murphy@utsouthwestern.edu.
⁴ Harold C. Simmons Comprehensive Cancer Center, Dallas, TX, USA. caitlin.murphy@utsouthwestern.edu.
⁵ Division of Epidemiology, Department of Clinical Sciences, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA. caitlin.murphy@utsouthwestern.edu.

PMID: 30155605
PMCID: PMC6628724
DOI: 10.1007/s10552-018-1077-1

Item in Clipboard

Abstract

Purpose: Colorectal cancer (CRC) incidence has declined over the past two decades; however, these declines have not occurred equally in all populations. To better understand the impact of CRC among Hispanics, we examined incidence trends by age and Hispanic ethnicity.

Methods: Using data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program, we estimated CRC incidence rates during the period 2001-2014, and across all 50 U.S. states. We estimated incidence rates in younger (age < 50 years) and older (age ≥ 50 years) adults by anatomic subsite and stage at diagnosis, separately for non-Hispanic Whites and Hispanic Whites.

Results: CRC incidence rates declined among older (age ≥ 50 years) Whites and Hispanics, but Whites experienced a greater decline (31% vs. 27% relative decline among Hispanics). In contrast to older adults, there were continued increases in CRC incidence from 2001 to 2014 among younger (age 20-49 years) adults. The largest relative increases in incidence occurred in Hispanics aged 20-29 years (90% vs. 50% relative increase among Whites).

Conclusions: Opposing incidence trends in younger versus older Hispanics may reflect generational differences in CRC risk by birth cohort, as well as environmental exposures and lifestyle-related risk factors associated with immigration and acculturation.

Keywords: Colorectal neoplasms; Hispanic Americans; Incidence; Population-based; Registries.

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Conflict of interest statement

Disclosures : The authors declare no conflicts of interest or financial disclosures.

Figures
Figure 1.

Age-specific incidence rates of colorectal…

Figure 1.

Age-specific incidence rates of colorectal cancer by 10-year age group and Hispanic ethnicity,…

Figure 1.

Age-specific incidence rates of colorectal cancer by 10-year age group and Hispanic ethnicity, National Program of Cancer Registries, 2001 – 2014 NOTE: Shaded regions in figure denote 95% confidence intervals

Figure 2.

Age-adjusted (2000 U.S. standard population)…

Figure 2.

Age-adjusted (2000 U.S. standard population) incidence of colorectal cancer by Hispanic ethnicity, age…

Figure 2.

Age-adjusted (2000 U.S. standard population) incidence of colorectal cancer by Hispanic ethnicity, age (+/− 50 years), and anatomic subsite, National Program of Cancer Registries, 2001 – 2014 NOTE: Proximal colon includes the cecum, ascending colon, hepatic flexure, and transverse colon; distal colon includes the splenic flexure, descending colon, and sigmoid colon; rectum includes the rectosigmoid junction and rectum. Shaded regions in figure denote 95% confidence intervals.

Figure 3.

Age-adjusted (2000 U.S. standard population)…

Figure 3.

Age-adjusted (2000 U.S. standard population) incidence of colorectal cancer by Hispanic ethnicity, age…

Figure 3.

Age-adjusted (2000 U.S. standard population) incidence of colorectal cancer by Hispanic ethnicity, age (+/− 50 years), and stage at diagnosis, National Program of Cancer Registries, 2001 – 2014 NOTE: Stage at diagnosis based on SEER summary staging, where local disease is limited to the large bowel, regional is limited to nearby lymph nodes or other organs, and distant is systematic metastasis. Shaded regions in figure denote 95% confidence intervals.