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Showing content from https://pubmed.ncbi.nlm.nih.gov/29492735/ below:

The risk of cardiovascular disease following breast cancer by Framingham risk score

. 2018 Jul;170(1):119-127. doi: 10.1007/s10549-018-4723-0. Epub 2018 Feb 28. The risk of cardiovascular disease following breast cancer by Framingham risk score

Affiliations

¹ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² , Utrecht, The Netherlands.
³ Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Utrecht University, Bilthoven, Utrecht, The Netherlands.
⁴ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
⁵ Department of Cardiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.
⁶ Department of Surgical Oncology, Utrecht University, Utrecht, The Netherlands.
⁷ Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
⁸ Imaging Division, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. h.m.verkooijen@umcutrecht.nl.
⁹ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.

PMID: 29492735
PMCID: PMC5993849
DOI: 10.1007/s10549-018-4723-0

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The risk of cardiovascular disease following breast cancer by Framingham risk score

Sofie A M Gernaat et al. Breast Cancer Res Treat. 2018 Jul.

. 2018 Jul;170(1):119-127. doi: 10.1007/s10549-018-4723-0. Epub 2018 Feb 28. Affiliations

¹ Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
² , Utrecht, The Netherlands.
³ Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Utrecht University, Bilthoven, Utrecht, The Netherlands.
⁴ Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
⁵ Department of Cardiology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.
⁶ Department of Surgical Oncology, Utrecht University, Utrecht, The Netherlands.
⁷ Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
⁸ Imaging Division, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. h.m.verkooijen@umcutrecht.nl.
⁹ Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.

PMID: 29492735
PMCID: PMC5993849
DOI: 10.1007/s10549-018-4723-0

Item in Clipboard

Abstract

Objectives: This study evaluates the risk of cardiovascular disease (CVD) following breast cancer, accounting for baseline CVD risk.

Methods: Within the EPIC-NL (Dutch part of the European Prospective Investigation into Nutrition and Cancer) cohort, 1103 women were diagnosed with breast cancer. For every breast cancer patient, 3-4 women without breast cancer (n = 4328) were selected matched for age, year, and time since cohort enrollment. Based on CVD risk factors at cohort enrollment, 10-year risk of CVD was calculated and categorized: low (< 10%), intermediate (10-20%), high (> 20%). Cox proportional hazard models assessed the risk of CVD events (hospitalization or mortality) and CVD mortality of women with versus without breast cancer, adjusted for baseline CVD risk.

Results: After median follow-up of 5 and 6 years, 92 (8.3%) and 325 (7.5%) CVD events occurred in women with and without breast cancer, respectively. In the low CVD risk group, women with breast cancer had 1.44 (95% CI 1.00-2.06) times higher risk of CVD events than women without breast cancer. In the intermediate and high CVD risk categories, risk of CVD events was similar in women with and without breast cancer. Overall, women with breast cancer had 1.77 (95% CI 1.10-2.86) times higher risk of CVD mortality than women without breast cancer.

Conclusions: Among women with low CVD risk, women with breast cancer have a higher risk of CVD event than women without breast cancer. Overall, women with breast cancer have a higher risk of CVD mortality than women without breast cancer.

Keywords: Breast cancer; Cardiovascular disease; Morbidity; Mortality; Risk.

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Conflict of interest statement Conflict of interest

The authors declare that they have no conflict of interest.

Ethics approval and consent to participate

The study complies with the Declaration of Helsinki and was approved by the institutional board of the University Medical Center Utrecht (Prospect) and the Medical Ethical Committee of TNO Nutrition and Food Research (MORGEN).