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Showing content from https://pubmed.ncbi.nlm.nih.gov/29433016/ below:

Self-sampling with HPV mRNA analyses from vagina and urine compared with cervical samples

Comparative Study

Affiliations

• ¹ Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Lund University, Sweden.
• ² Department of Clinical Microbiology, Skåne University Hospital, Lund, Lund University, Sweden.
• ³ Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Lund University, Sweden. Electronic address: christer.borgfeldt@med.lu.se.

• PMID: 29433016
• DOI: 10.1016/j.jcv.2018.02.002

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Comparative Study

Katrin Christine Asciutto et al. J Clin Virol. 2018 Apr.

• ¹ Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Lund University, Sweden.
• ² Department of Clinical Microbiology, Skåne University Hospital, Lund, Lund University, Sweden.
• ³ Department of Obstetrics and Gynecology, Skåne University Hospital, Lund, Lund University, Sweden. Electronic address: christer.borgfeldt@med.lu.se.

• PMID: 29433016
• DOI: 10.1016/j.jcv.2018.02.002

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Background: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested.

Objectives: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens.

Study design: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 209 women with the Aptima mRNA assay (Hologic Inc, MA, USA). Cervical cytology, colposcopy, biopsy and/or the loop electrosurgical excision procedure (LEEP) were performed in every examination.

Results: The sensitivity of the HPV mRNA test in detecting high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer cases was as follows: for the vaginal self-samples 85.5% (95% CI; 75.0-92.8), the urinary samples 44.8% (95% CI; 32.6-57.4), and for routine cytology 81.7% (95% CI; 70.7-89.9). For the clinician-taken cervical HPV samples the sensitivity of the HPV mRNA test in detecting HSIL/AIS/cancer was 100.0% (95% CI; 94.9-100.0). The specificity of the HPV mRNA was similar for the clinician-taken cervical HPV samples and the self-samples: 49.0% vs. 48.1%. The urinary HPV samples had a specificity of 61.9% and cytology had a specificity of 93.3%.

Conclusion: The sensitivity of the Aptima HPV mRNA test in detecting HSIL/AIS/cancer from vaginal self-samples was similar to that of routine cytology. The Aptima HPV mRNA vaginal self-sampling analysis may serve as a complement in screening programs.

Keywords: HPV analyses; HPV mRNA; Self-collected vaginal smear; Urinary sample.

Copyright © 2018 Elsevier B.V. All rights reserved.

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