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Showing content from https://pubmed.ncbi.nlm.nih.gov/27639328/ below:

Patients With Nonpolypoid (Flat and Depressed) Colorectal Neoplasms at Increased Risk for Advanced Neoplasias, Compared With Patients With Polypoid Neoplasms

Affiliations

• ¹ Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
• ² Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California.
• ³ Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
• ⁴ Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California. Electronic address: endoresection@me.com.

• PMID: 27639328
• DOI: 10.1016/j.cgh.2016.08.045

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Sarah K McGill et al. Clin Gastroenterol Hepatol. 2017 Feb.

• ¹ Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California; University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
• ² Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California.
• ³ Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
• ⁴ Veterans Affairs Palo Alto Health Care System, Palo Alto, California; Stanford University School of Medicine, Stanford, California. Electronic address: endoresection@me.com.

• PMID: 27639328
• DOI: 10.1016/j.cgh.2016.08.045

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Background & aims: Nonpolypoid colorectal neoplasms (NP-CRNs) are more likely to contain high-grade dysplasia or early-stage cancer than polypoid neoplasms. We aimed to determine the long-term outcomes of patients with at least 1 NP-CRN.

Methods: We performed a longitudinal cohort study of 4454 patients at a Veterans' Affairs hospital who underwent colonoscopy from 2000 through 2005; 341 were found to have 1 or more NP-CRNs and were matched (3:1) with patients found to have 1 or more polypoid neoplasms (controls, n = 1025). We collected and analyzed data on baseline colonoscopy findings and first follow-up colonoscopy results through August 2014. We calculated the incidence of advanced neoplasia at first follow-up colonoscopy, as defined by the presence of ≥1 tubular or sessile serrated adenomas ≥10 mm in diameter, tubulovillous adenoma, high-grade dysplasia, or invasive cancer.

Results: A significantly higher proportion of patients with 1 or more NP-CRNs (16.0%) were found to have advanced neoplasia at their first follow-up colonoscopy than controls (8.6%); the adjusted risk ratio was 1.6 (95% confidence interval, 1.05-2.6; P = .03). A significantly higher proportion of patients with 1 or more NP-CRNs were found to have additional NP-CRNs at the follow-up colonoscopy (17%) than controls (7%; relative risk, 2.3; 95% confidence interval, 1.5-3.5; P < .001). Similar proportions of patients in each group developed cancers after colonoscopy.

Conclusions: In a longitudinal cohort study, we found that patients with NP-CRN were more likely to develop additional NP-CRNs and to have advanced neoplasms at their first follow-up colonoscopy than patients with only polypoid neoplasms. However, patients with NP-CRN were not more likely to develop cancers after colonoscopy when surveillance guidelines were followed. Larger studies are needed to determine risk of colorectal cancer in patients with NP-CRN.

Keywords: Colon Cancer; Endoscopy; Progression; Risk Factors; Screening.

Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.

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• Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults.

  Soetikno RM, Kaltenbach T, Rouse RV, Park W, Maheshwari A, Sato T, Matsui S, Friedland S. Soetikno RM, et al. JAMA. 2008 Mar 5;299(9):1027-35. doi: 10.1001/jama.299.9.1027. JAMA. 2008. PMID: 18319413

• Prevalence of nonpolypoid colorectal neoplasms in symptomatic patients scheduled for colonoscopy: a study with total colonic chromoscopy.

  Bustamante-Balén M, Bernet L, Cano R, Pertejo V, Ponce J. Bustamante-Balén M, et al. J Clin Gastroenterol. 2010 Apr;44(4):280-5. doi: 10.1097/MCG.0b013e3181aed327. J Clin Gastroenterol. 2010. PMID: 19713863

• Prevalence and characteristics of nonpolypoid colorectal neoplasm in an asymptomatic and average-risk Chinese population.

  Chiu HM, Lin JT, Chen CC, Lee YC, Liao WC, Liang JT, Shun CT, Wang HP, Wu MS. Chiu HM, et al. Clin Gastroenterol Hepatol. 2009 Apr;7(4):463-70. doi: 10.1016/j.cgh.2008.11.026. Epub 2008 Dec 13. Clin Gastroenterol Hepatol. 2009. PMID: 19264577

• Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.

  Winawer SJ, Zauber AG, Fletcher RH, Stillman JS, O'Brien MJ, Levin B, Smith RA, Lieberman DA, Burt RW, Levin TR, Bond JH, Brooks D, Byers T, Hyman N, Kirk L, Thorson A, Simmang C, Johnson D, Rex DK; US Multi-Society Task Force on Colorectal Cancer; American Cancer Society. Winawer SJ, et al. Gastroenterology. 2006 May;130(6):1872-85. doi: 10.1053/j.gastro.2006.03.012. Gastroenterology. 2006. PMID: 16697750 Review.

• Relationship of non-polypoid colorectal neoplasms to quality of colonoscopy.

  Kahi CJ, Hewett DG, Rex DK. Kahi CJ, et al. Gastrointest Endosc Clin N Am. 2010 Jul;20(3):407-15. doi: 10.1016/j.giec.2010.03.001. Gastrointest Endosc Clin N Am. 2010. PMID: 20656239 Review.

• Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.

  Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Gupta S, et al. Am J Gastroenterol. 2020 Mar;115(3):415-434. doi: 10.14309/ajg.0000000000000544. Am J Gastroenterol. 2020. PMID: 32039982 Free PMC article. No abstract available.

• Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.

  Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Gupta S, et al. Gastrointest Endosc. 2020 Mar;91(3):463-485.e5. doi: 10.1016/j.gie.2020.01.014. Epub 2020 Feb 7. Gastrointest Endosc. 2020. PMID: 32044106 Free PMC article. No abstract available.

• Metachronous neoplasms in patients with laterally spreading tumours during surveillance.

  Bogie RMM, Winkens B, Retra SJJ, le Clercq CMC, Bouwens MW, Rondagh EJA, Chang LC, de Ridder R, Hoge C, Straathof JW, Goudkade D, Sanduleanu-Dascalescu S, Masclee AAM. Bogie RMM, et al. United European Gastroenterol J. 2021 Apr;9(3):378-387. doi: 10.1177/2050640620965317. Epub 2021 Feb 18. United European Gastroenterol J. 2021. PMID: 33245025 Free PMC article.

• Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.

  Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Gupta S, et al. Gastroenterology. 2020 Mar;158(4):1131-1153.e5. doi: 10.1053/j.gastro.2019.10.026. Epub 2020 Feb 7. Gastroenterology. 2020. PMID: 32044092 Free PMC article. No abstract available.

• Trends in EMR for nonmalignant colorectal polyps in the United States.

  Yu JX, Lin JL, Oliver M, Soetikno R, Chang MS, Kwong AJ, Limketkai BN, Bhattacharya J, Kaltenbach T. Yu JX, et al. Gastrointest Endosc. 2020 Jan;91(1):124-131.e4. doi: 10.1016/j.gie.2019.08.004. Epub 2019 Aug 19. Gastrointest Endosc. 2020. PMID: 31437455 Free PMC article.

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