Practice Guideline
. 2016 Jun 21;315(23):2564-2575. doi: 10.1001/jama.2016.5989. Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement Kirsten Bibbins-Domingo 1 , David C Grossman 2 , Susan J Curry 3 , Karina W Davidson 4 , John W Epling Jr 5 , Francisco A R García 6 , Matthew W Gillman 7 , Diane M Harper 8 , Alex R Kemper 9 , Alex H Krist 10 , Ann E Kurth 11 , C Seth Landefeld 12 , Carol M Mangione 13 , Douglas K Owens 14 , William R Phillips 15 , Maureen G Phipps 16 , Michael P Pignone 17 , Albert L Siu 18Affiliations
AffiliationsItem in Clipboard
Practice Guideline
Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation StatementUS Preventive Services Task Force et al. JAMA. 2016.
. 2016 Jun 21;315(23):2564-2575. doi: 10.1001/jama.2016.5989. Authors US Preventive Services Task Force; Kirsten Bibbins-Domingo 1 , David C Grossman 2 , Susan J Curry 3 , Karina W Davidson 4 , John W Epling Jr 5 , Francisco A R García 6 , Matthew W Gillman 7 , Diane M Harper 8 , Alex R Kemper 9 , Alex H Krist 10 , Ann E Kurth 11 , C Seth Landefeld 12 , Carol M Mangione 13 , Douglas K Owens 14 , William R Phillips 15 , Maureen G Phipps 16 , Michael P Pignone 17 , Albert L Siu 18 AffiliationsItem in Clipboard
Erratum in[No authors listed] [No authors listed] JAMA. 2016 Aug 2;316(5):545. doi: 10.1001/jama.2016.9943. JAMA. 2016. PMID: 27483080 No abstract available.
[No authors listed] [No authors listed] JAMA. 2017 Jun 6;317(21):2239. doi: 10.1001/jama.2017.5918. JAMA. 2017. PMID: 28586871 No abstract available.
Importance: Colorectal cancer is the second leading cause of cancer death in the United States. In 2016, an estimated 134,000 persons will be diagnosed with the disease, and about 49,000 will die from it. Colorectal cancer is most frequently diagnosed among adults aged 65 to 74 years; the median age at death from colorectal cancer is 68 years.
Objective: To update the 2008 US Preventive Services Task Force (USPSTF) recommendation on screening for colorectal cancer.
Evidence review: The USPSTF reviewed the evidence on the effectiveness of screening with colonoscopy, flexible sigmoidoscopy, computed tomography colonography, the guaiac-based fecal occult blood test, the fecal immunochemical test, the multitargeted stool DNA test, and the methylated SEPT9 DNA test in reducing the incidence of and mortality from colorectal cancer or all-cause mortality; the harms of these screening tests; and the test performance characteristics of these tests for detecting adenomatous polyps, advanced adenomas based on size, or both, as well as colorectal cancer. The USPSTF also commissioned a comparative modeling study to provide information on optimal starting and stopping ages and screening intervals across the different available screening methods.
Findings: The USPSTF concludes with high certainty that screening for colorectal cancer in average-risk, asymptomatic adults aged 50 to 75 years is of substantial net benefit. Multiple screening strategies are available to choose from, with different levels of evidence to support their effectiveness, as well as unique advantages and limitations, although there are no empirical data to demonstrate that any of the reviewed strategies provide a greater net benefit. Screening for colorectal cancer is a substantially underused preventive health strategy in the United States.
Conclusions and recommendations: The USPSTF recommends screening for colorectal cancer starting at age 50 years and continuing until age 75 years (A recommendation). The decision to screen for colorectal cancer in adults aged 76 to 85 years should be an individual one, taking into account the patient's overall health and prior screening history (C recommendation).
Comment inPinsky PF, Doroudi M. Pinsky PF, et al. JAMA. 2016 Oct 25;316(16):1715. doi: 10.1001/jama.2016.13849. JAMA. 2016. PMID: 27784086 No abstract available.
Mergener K, Potter NT. Mergener K, et al. JAMA. 2016 Oct 25;316(16):1716. doi: 10.1001/jama.2016.14915. JAMA. 2016. PMID: 27784087 No abstract available.
Levine P, Gould-Suarez M. Levine P, et al. JAMA. 2016 Oct 25;316(16):1715-1716. doi: 10.1001/jama.2016.14918. JAMA. 2016. PMID: 27784088 No abstract available.
Jin J. Jin J. JAMA. 2016 Jun 21;315(23):2635. doi: 10.1001/jama.2016.7569. JAMA. 2016. PMID: 27305107 No abstract available.
US Preventive Services Task Force; Davidson KW, Barry MJ, Mangione CM, Cabana M, Caughey AB, Davis EM, Donahue KE, Doubeni CA, Krist AH, Kubik M, Li L, Ogedegbe G, Owens DK, Pbert L, Silverstein M, Stevermer J, Tseng CW, Wong JB. US Preventive Services Task Force, et al. JAMA. 2021 May 18;325(19):1965-1977. doi: 10.1001/jama.2021.6238. JAMA. 2021. PMID: 34003218
Knudsen AB, Zauber AG, Rutter CM, Naber SK, Doria-Rose VP, Pabiniak C, Johanson C, Fischer SE, Lansdorp-Vogelaar I, Kuntz KM. Knudsen AB, et al. JAMA. 2016 Jun 21;315(23):2595-609. doi: 10.1001/jama.2016.6828. JAMA. 2016. PMID: 27305518 Free PMC article.
Lin JS, Piper MA, Perdue LA, Rutter CM, Webber EM, O'Connor E, Smith N, Whitlock EP. Lin JS, et al. JAMA. 2016 Jun 21;315(23):2576-94. doi: 10.1001/jama.2016.3332. JAMA. 2016. PMID: 27305422 Review.
Knudsen AB, Rutter CM, Peterse EFP, Lietz AP, Seguin CL, Meester RGS, Perdue LA, Lin JS, Siegel RL, Doria-Rose VP, Feuer EJ, Zauber AG, Kuntz KM, Lansdorp-Vogelaar I. Knudsen AB, et al. JAMA. 2021 May 18;325(19):1998-2011. doi: 10.1001/jama.2021.5746. JAMA. 2021. PMID: 34003219 Free PMC article.
Whitlock EP, Lin JS, Liles E, Beil TL, Fu R. Whitlock EP, et al. Ann Intern Med. 2008 Nov 4;149(9):638-58. doi: 10.7326/0003-4819-149-9-200811040-00245. Epub 2008 Oct 6. Ann Intern Med. 2008. PMID: 18838718 Review.
Shi Y, Li J, Tang M, Liu J, Zhong Y, Huang W. Shi Y, et al. Front Oncol. 2022 Oct 13;12:937209. doi: 10.3389/fonc.2022.937209. eCollection 2022. Front Oncol. 2022. PMID: 36313671 Free PMC article.
Luu XQ, Lee K, Lee YY, Suh M, Kim Y, Choi KS. Luu XQ, et al. World J Gastroenterol. 2020 Jul 21;26(27):3963-3974. doi: 10.3748/wjg.v26.i27.3963. World J Gastroenterol. 2020. PMID: 32774070 Free PMC article.
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Cheng E, Blackburn HN, Ng K, Spiegelman D, Irwin ML, Ma X, Gross CP, Tabung FK, Giovannucci EL, Kunz PL, Llor X, Billingsley K, Meyerhardt JA, Ahuja N, Fuchs CS. Cheng E, et al. JAMA Netw Open. 2021 Jun 1;4(6):e2112539. doi: 10.1001/jamanetworkopen.2021.12539. JAMA Netw Open. 2021. PMID: 34132794 Free PMC article.
Seo JY, Han YM, Chung SJ, Lim SH, Bae JH, Chung GE. Seo JY, et al. Cancers (Basel). 2022 Oct 26;14(21):5256. doi: 10.3390/cancers14215256. Cancers (Basel). 2022. PMID: 36358673 Free PMC article.
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