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Showing content from https://pubmed.ncbi.nlm.nih.gov/26975233/ below:

Association between adenoma location and risk of recurrence

doi: 10.1016/j.gie.2016.02.048. Epub 2016 Mar 11. Association between adenoma location and risk of recurrence

Affiliations

¹ Department of Gastroenterology, VA Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
² Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
³ Department of Medicine, University of Colorado, Denver, Colorado.
⁴ Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.
⁵ Department of Gastroenterology, MD Anderson Cancer Center, Houston, Texas.
⁶ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
⁷ Section of Gastroenterology, Minneapolis VAHCS and University of Minnesota, Minneapolis, Minnesota.
⁸ Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.

PMID: 26975233
PMCID: PMC5586081
DOI: 10.1016/j.gie.2016.02.048

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Association between adenoma location and risk of recurrence

Heiko Pohl et al. Gastrointest Endosc. 2016 Oct.

doi: 10.1016/j.gie.2016.02.048. Epub 2016 Mar 11. Authors Heiko Pohl¹, Douglas J Robertson¹, Leila A Mott², Dennis J Ahnen³, Carol A Burke⁴, Elizabeth L Barry², Robert S Bresalier⁵, Jane C Figueiredo⁶, Aasma Shaukat⁷, Robert S Sandler⁸, John A Baron⁸ Affiliations

¹ Department of Gastroenterology, VA Medical Center, White River Junction, Vermont; Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
² Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
³ Department of Medicine, University of Colorado, Denver, Colorado.
⁴ Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.
⁵ Department of Gastroenterology, MD Anderson Cancer Center, Houston, Texas.
⁶ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
⁷ Section of Gastroenterology, Minneapolis VAHCS and University of Minnesota, Minneapolis, Minnesota.
⁸ Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.

PMID: 26975233
PMCID: PMC5586081
DOI: 10.1016/j.gie.2016.02.048

Item in Clipboard

Abstract

Background and aims: The biological environment varies across the colorectum and may therefore affect neoplastic growth differently in the proximal and distal colon. The aim of the study was to evaluate the risk for recurrent adenomas and their anatomic location based on adenoma location at baseline colonoscopy.

Methods: Data were extracted from 3 adenoma prevention trials (n = 2430). Participants had at least 1 adenoma at baseline colonoscopy and underwent subsequent surveillance colonoscopy, at which time metachronous adenomas could be detected. We calculated the risk ratio (RR) and the 95% confidence interval (CI) for metachronous adenomas by location of the baseline lesion and considered the impact of advanced neoplasia and multiplicity.

Results: At baseline, 522 patients (21.5%) had adenomas only in the proximal colon, 1266 patients (52.1%) had adenomas only in the distal colorectum, and 642 (26.4%) had adenomas in both regions. Overall, 877 patients (36.5%) had metachronous adenomas during the follow-up period. Those with only proximal adenomas at baseline had a higher risk of metachronous adenomas compared with patients with only distal adenomas (RR, 1.17; 95% CI, 1.01-1.35). A greater proximal risk was found after restricting the analysis to patients with multiple proximal adenomas versus multiple distal adenomas (RR, 1.35; 95% CI, 1.10-1.67). The risk of recurrent adenomas on the same side was 48% higher for patients with only proximal adenomas at baseline compared with those with only distal adenomas at baseline (RR, 1.48; 95% CI, 1.22-1.80).

Conclusions: Patients with proximal adenomas only have a modestly greater risk of adenoma recurrence than patients with adenomas limited to the distal colon, and have a greater likelihood of adenoma recurrence on the same side compared with patients with distal adenomas. This observation suggests that biological factors may differentially affect neoplasia growth across the colon.

Published by Elsevier Inc.

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Figures
Figure 1

Metachronous adenoma risk in relation…

Figure 1

Metachronous adenoma risk in relation to adenoma location at baseline colonoscopy.

Figure 1

Metachronous adenoma risk in relation to adenoma location at baseline colonoscopy.

Figure 2

Metachronous advanced adenomas in relation…

Figure 2

Metachronous advanced adenomas in relation to adenoma location at baseline colonoscopy.

Figure 2

Metachronous advanced adenomas in relation to adenoma location at baseline colonoscopy.

Figure 3

Side of metachronous adenomas by…

Figure 3

Side of metachronous adenomas by adenoma location at baseline. The risk ratio expresses…

Figure 3

Side of metachronous adenomas by adenoma location at baseline. The risk ratio expresses the risk of ipsilateral (same side) recurrence for subjects with only proximal adenomas at baseline to have any proximal metachronous adenoma in comparison to subjects with only distal adenomas at baseline to have any distal metachronous adenomas.

Figure 4

Side of metachronous advanced adenomas…

Figure 4

Side of metachronous advanced adenomas by adenoma location at baseline. The risk ratio…

Figure 4

Side of metachronous advanced adenomas by adenoma location at baseline. The risk ratio expresses the risk of ipsilateral (same side) recurrence for subjects with only proximal adenomas at baseline to have any proximal metachronous advanced adenoma in comparison to subjects with only distal sided adenomas at baseline to have any distal metachronous advanced adenomas.