RetroSearch Browse

Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/26808257/ below:

Impact of Widespread Cervical Cancer Screening: Number of Cancers Prevented and Changes in Race-specific Incidence

. 2018 Mar;41(3):289-294. doi: 10.1097/COC.0000000000000264. Impact of Widespread Cervical Cancer Screening: Number of Cancers Prevented and Changes in Race-specific Incidence

Affiliations

¹ Yale University School of Medicine.
² Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center.
³ Departments of Internal Medicine.
⁴ Therapeutic Radiology, Yale School of Medicine, New Haven, CT.

PMID: 26808257
PMCID: PMC4958036
DOI: 10.1097/COC.0000000000000264

Item in Clipboard

Impact of Widespread Cervical Cancer Screening: Number of Cancers Prevented and Changes in Race-specific Incidence

Daniel X Yang et al. Am J Clin Oncol. 2018 Mar.

. 2018 Mar;41(3):289-294. doi: 10.1097/COC.0000000000000264. Affiliations

¹ Yale University School of Medicine.
² Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center.
³ Departments of Internal Medicine.
⁴ Therapeutic Radiology, Yale School of Medicine, New Haven, CT.

PMID: 26808257
PMCID: PMC4958036
DOI: 10.1097/COC.0000000000000264

Item in Clipboard

Abstract

Objectives: With recent approval of standalone HPV testing and increasing uptake of HPV vaccination, some have postulated that we are moving toward a "post-Pap" era of cervical cancer prevention. However, the total number cases that have been prevented by Pap smear screening as well as its impact on racial disparities are unknown.

Methods: We estimated national cervical cancer incidence from 1976 to 2009 using the Surveillance, Epidemiology, and End Result database. Screening data were obtained from the literature and National Cancer Institute Progress Reports. We examined early, late, and race-specific trends in cancer incidence, and calculated the estimated number of cancers prevented over the past 3 decades.

Results: From 1976 to 2009, there was a significant decrease in the incidence of early-stage cervical cancer, from 9.8 to 4.9 cases per 100,000 women (P<0.001). Late-stage disease incidence also decreased, from 5.3 to 3.7 cases per 100,000 women (P<0.001). The incidence among black women decreased from 26.9 to 9.7 cases per 100,000 women (P<0.001), a greater decline compared with that of white women and women of other races. After adjusting for "prescreening era" rates of cervical cancer, we estimate that Pap smears were associated with a reduction of between 105,000 and 492,000 cases of cervical cancer over the past 3 decades in the United States.

Conclusions: A large number of early-stage and late-stage cervical cancers were prevented and racial disparity in cancer rates were reduced during an era of widespread Pap smear screening.

PubMed Disclaimer

Figures
Fig. 1

Pap smear utilization rates and…

Fig. 1

Pap smear utilization rates and associated changes in early- and late-stage cervical cancer…

Fig. 1

Pap smear utilization rates and associated changes in early- and late-stage cervical cancer incidence

Fig. 2

Trends in race-specific cervical cancer…

Fig. 2

Trends in race-specific cervical cancer incidence among U.S. women age 18 to 65

Fig. 2

Trends in race-specific cervical cancer incidence among U.S. women age 18 to 65

Fig. 3

Actual cancer incidence compared to…

Fig. 3

Actual cancer incidence compared to baseline incidence. Area under curve represents the number…

Fig. 3

Actual cancer incidence compared to baseline incidence. Area under curve represents the number of cancer cases reduced from baseline