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Showing content from https://pubmed.ncbi.nlm.nih.gov/26117178/ below:

High-risk metachronous polyps are more frequent in patients with traditional serrated adenomas than in patients with conventional adenomas: a multicenter prospective study

Clinical Trial

Affiliations

• ¹ Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
• ² Sungkyunkwan University School of Medicine, Seoul, Korea.
• ³ Soonchunhyang University College of Medicine, Seoul, Cheonan, Korea.
• ⁴ University of Ulsan College of Medicine, Seoul, Korea.
• ⁵ Kosin University College of Medicine, Pusan, Korea.
• ⁶ Yonsei University, Wonju College of Medicine, Wonju, Korea.
• ⁷ Korea University College of Medicine, Seoul, Korea.
• ⁸ Hallym University College of Medicine, Pyeongchon, Korea.
• ⁹ Hanyang University College of Medicine, Guri, Korea.

• PMID: 26117178
• DOI: 10.1016/j.gie.2015.05.016

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Clinical Trial

Jin Young Yoon et al. Gastrointest Endosc. 2015 Dec.

• ¹ Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
• ² Sungkyunkwan University School of Medicine, Seoul, Korea.
• ³ Soonchunhyang University College of Medicine, Seoul, Cheonan, Korea.
• ⁴ University of Ulsan College of Medicine, Seoul, Korea.
• ⁵ Kosin University College of Medicine, Pusan, Korea.
• ⁶ Yonsei University, Wonju College of Medicine, Wonju, Korea.
• ⁷ Korea University College of Medicine, Seoul, Korea.
• ⁸ Hallym University College of Medicine, Pyeongchon, Korea.
• ⁹ Hanyang University College of Medicine, Guri, Korea.

• PMID: 26117178
• DOI: 10.1016/j.gie.2015.05.016

Item in Clipboard

Background and aims: Although the malignant progression of serrated polyps has been clearly documented, the malignant potential of the traditional serrated adenoma (TSA) subtype has not been established. We compared the prevalence of metachronous polyps in surveillance colonoscopies between patients with TSA and those with conventional adenomas (CAs).

Methods: Four hundred twenty patients were diagnosed with TSAs by current diagnostic criteria at 10 tertiary care university hospitals in Korea from January 2003 to December 2005; 186 patients who received surveillance colonoscopy after removal of initial polyps were enrolled. During the same time period, 372 age- and sex-matched patients diagnosed with CAs were used as a control group.

Results: TSA patients had a significantly higher recurrence rate of colorectal polyps compared with CA patients (66.1% vs 43.5%, respectively). TSA patients had a greater number (3 vs 2) and larger size (8.6 ± 5.7 vs 6.3 ± 5.2 mm) of recurrent polyps compared with CA patients. TSA patients also had a higher rate of CA (54.8% vs 37.9%), serrated adenoma (14.0% vs. 0.8%), and hyperplastic polyp (33.3% vs. 13.7%) recurrence compared with CA patients. TSA patients had significantly greater odds of having a recurrent high-risk polyp than CA patients (odds ratio, 2.37; 95% confidence interval, 1.55-3.63).

Conclusions: In comparison with patients with CAs, patients with TSAs have a higher metachronous occurrence rate of all polyp subtypes including CAs, serrated adenomas, and hyperplastic polyps. Moreover, the presence of TSAs is an independent predictor of a high-risk polyp occurrence.

Copyright © 2015 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. All rights reserved.

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