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Showing content from https://pubmed.ncbi.nlm.nih.gov/25721570/ below:

Grading the strength of a body of evidence when assessing health care interventions: an EPC update

. 2015 Nov;68(11):1312-24. doi: 10.1016/j.jclinepi.2014.11.023. Epub 2014 Dec 20. Grading the strength of a body of evidence when assessing health care interventions: an EPC update Kathleen N Lohr², Mohammed T Ansari³, Ethan M Balk⁴, Robert Kane⁵, Marian McDonagh⁶, Sally C Morton⁷, Meera Viswanathan², Eric B Bass⁸, Mary Butler⁵, Gerald Gartlehner⁹, Lisa Hartling¹⁰, Melissa McPheeters¹¹, Laura C Morgan², James Reston¹², Priyanka Sista¹³, Evelyn Whitlock¹⁴, Stephanie Chang¹⁵

Affiliations

¹ Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: berkman@rti.org.
² Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
³ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Box 201B, Ottawa Hospital - General campus, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
⁴ Center for Evidence-Based Medicine, Brown University, School of Public Health, Box G-S121-8, Providence, RI 02912, USA.
⁵ University of Minnesota, School of Public Health, 420 Delaware St SE, MMC 197, Minneapolis, MN 55455, USA.
⁶ Pacific Northwest Evidence-based Practice Center, Oregon Health Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
⁷ Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburg, PA 15261, USA.
⁸ Department of Medicine, and Department of Health Policy and Management, Johns Hopkins University, 624 North Broadway, Room 680A, Baltimore, MD, 21205, USA.
⁹ Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA; Department for Clinical Epidemiology and Evidence-based Medicine, Danube University, Dr. Karl Dorrek Strasse 30, 3500 Krems, Austria.
¹⁰ Department of Pediatrics, University of Alberta, ECHA 4-472, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada.
¹¹ Department of Health Policy, Vanderbilt University, Medical Center, 6th Floor, 2525 West End Avenue, Nashville, TN 37203, USA.
¹² Evidence-Based Practice Center and Health Technology Assessment Group, ECRI Institute Headquarters, 5200 Butler Pike, Plymouth Meeting, PA 19462, USA.
¹³ University of North Carolina School of Medicine, 1001 Bondurant Hall, CB# 9535, Chapel Hill, NC 27599, USA.
¹⁴ Center for Health Research, Kaiser Permanente, Northwest, 3800 N. Interstate Avenue, Portland, OR 97227, USA.
¹⁵ Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.

PMID: 25721570
DOI: 10.1016/j.jclinepi.2014.11.023

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Grading the strength of a body of evidence when assessing health care interventions: an EPC update

Nancy D Berkman et al. J Clin Epidemiol. 2015 Nov.

. 2015 Nov;68(11):1312-24. doi: 10.1016/j.jclinepi.2014.11.023. Epub 2014 Dec 20. Authors Nancy D Berkman¹, Kathleen N Lohr², Mohammed T Ansari³, Ethan M Balk⁴, Robert Kane⁵, Marian McDonagh⁶, Sally C Morton⁷, Meera Viswanathan², Eric B Bass⁸, Mary Butler⁵, Gerald Gartlehner⁹, Lisa Hartling¹⁰, Melissa McPheeters¹¹, Laura C Morgan², James Reston¹², Priyanka Sista¹³, Evelyn Whitlock¹⁴, Stephanie Chang¹⁵ Affiliations

¹ Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: berkman@rti.org.
² Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
³ Clinical Epidemiology Program, Ottawa Hospital Research Institute, Box 201B, Ottawa Hospital - General campus, 501 Smyth Road, Ottawa, ON K1H 8L6, Canada.
⁴ Center for Evidence-Based Medicine, Brown University, School of Public Health, Box G-S121-8, Providence, RI 02912, USA.
⁵ University of Minnesota, School of Public Health, 420 Delaware St SE, MMC 197, Minneapolis, MN 55455, USA.
⁶ Pacific Northwest Evidence-based Practice Center, Oregon Health Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
⁷ Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburg, PA 15261, USA.
⁸ Department of Medicine, and Department of Health Policy and Management, Johns Hopkins University, 624 North Broadway, Room 680A, Baltimore, MD, 21205, USA.
⁹ Division of Social Policy, Health & Economics Research, RTI International (Research Triangle Institute), PO Box 12194, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA; Department for Clinical Epidemiology and Evidence-based Medicine, Danube University, Dr. Karl Dorrek Strasse 30, 3500 Krems, Austria.
¹⁰ Department of Pediatrics, University of Alberta, ECHA 4-472, 11405-87 Avenue, Edmonton, Alberta, T6G 1C9, Canada.
¹¹ Department of Health Policy, Vanderbilt University, Medical Center, 6th Floor, 2525 West End Avenue, Nashville, TN 37203, USA.
¹² Evidence-Based Practice Center and Health Technology Assessment Group, ECRI Institute Headquarters, 5200 Butler Pike, Plymouth Meeting, PA 19462, USA.
¹³ University of North Carolina School of Medicine, 1001 Bondurant Hall, CB# 9535, Chapel Hill, NC 27599, USA.
¹⁴ Center for Health Research, Kaiser Permanente, Northwest, 3800 N. Interstate Avenue, Portland, OR 97227, USA.
¹⁵ Center for Evidence and Practice Improvement, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD 20850, USA.

PMID: 25721570
DOI: 10.1016/j.jclinepi.2014.11.023

Item in Clipboard

Abstract

Objectives: To revise 2010 guidance on grading the strength of evidence (SOE) of the effectiveness of drugs, devices, and other preventive and therapeutic interventions in systematic reviews produced by the Evidence-based Practice Center (EPC) program, established by the US Agency for Healthcare Research and Quality (AHRQ).

Study design and setting: A cross-EPC working group reviewed authoritative systems for grading SOE [primarily the approach from the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group] and conducted extensive discussions with GRADE and other experts.

Results: Updated guidance continues to be conceptually similar to GRADE. Reviewers are to evaluate SOE separately for each major treatment comparison for each major outcome. We added reporting bias as a required domain and retained study limitations (risk of bias), consistency, directness, and precision (and three optional domains). Additional guidance covers scoring consistency, precision, and reporting bias, grading bodies of evidence with randomized controlled trials and observational studies, evaluating single study bodies of evidence, using studies with high risk of bias, and presenting findings with greater clarity and transparency. SOE is graded high, moderate, low, or insufficient, reflecting reviewers' confidence in the findings for a specific treatment comparison and outcome.

Conclusion: No single approach for grading SOE suits all reviews, but a more consistent and transparent approach to reporting summary information will make reviews more useful to the broad range of audiences that AHRQ's work aims to reach. EPC working groups will consider ongoing challenges and modify guidance as needed, on issues such as combining trials and observational studies in bodies of evidence, weighting domains, and combining qualitative and quantitative syntheses.

Keywords: Clinical practice guidelines; Evidence-based practice; Health care delivery; Health policy; Methods; Minimally important differences; Optimal information size; Strength of evidence; Systematic reviews.

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