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Showing content from https://pubmed.ncbi.nlm.nih.gov/25203483/ below:

Participant uptake of the fecal immunochemical test decreases with the two-sample regimen compared with one-sample FIT

Randomized Controlled Trial

doi: 10.1097/CEJ.0000000000000084. Participant uptake of the fecal immunochemical test decreases with the two-sample regimen compared with one-sample FIT

Affiliations

Affiliation

¹ aCenter for Health Research bNorthwest Permanente, Kaiser Permanente Northwest, Portland, Oregon, USA.

PMID: 25203483
PMCID: PMC4186737
DOI: 10.1097/CEJ.0000000000000084

Free PMC article

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Randomized Controlled Trial

Participant uptake of the fecal immunochemical test decreases with the two-sample regimen compared with one-sample FIT

David M Mosen et al. Eur J Cancer Prev. 2014 Nov.

Free PMC article doi: 10.1097/CEJ.0000000000000084. Affiliation

¹ aCenter for Health Research bNorthwest Permanente, Kaiser Permanente Northwest, Portland, Oregon, USA.

PMID: 25203483
PMCID: PMC4186737
DOI: 10.1097/CEJ.0000000000000084

Item in Clipboard

Abstract

Background: Fecal immunochemical tests (FITs) are recommended to screen average-risk adults for colorectal cancer (CRC). Little research has examined whether a two-sample FIT affects participant uptake, compared with a one-sample FIT. Examining participant uptake is important, as evidence suggests that a two-sample FIT may increase the sensitivity to detect CRC.

Objective: This study had two objectives: (i) to evaluate FIT completion in a population that received either a one-sample FIT kit (1-FIT) or a two-sample FIT kit (2-FIT) and (ii) to understand whether uptake varies by age, sex, or receipt of prior CRC screening.

Methods: We conducted a randomized controlled trial in which 3081 participants who were aged between 50 and 75 years and were at an average risk for CRC, and who had requested FITs, randomly received 1-FIT (n=1540) or 2-FIT (n=1541) kits. FIT completion was defined as the completion and return of a one-sample test by the patients in the 1-FIT group or of both sample tests by those in the 2-FIT group. Cox proportional hazard regression models were used to determine the independent effect of group type (2-FIT vs. 1-FIT) on the completion of the FIT, adjusting for age, sex, and receipt of prior CRC screening.

Results: The 2-FIT group had lower test completion rates (hazard ratio=0.87; 95% confidence interval=0.78-0.97; P=0.01) after adjusting for age, sex, and receipt of prior CRC screening. Participant uptake did not vary by age, sex, or receipt of prior CRC screening.

Conclusion: This unique, rigorous randomized controlled trial found that the 2-FIT regimen decreases completion of FIT. Further research is needed to understand whether decreases in participant uptake are offset by increased gains in test sensitivity.

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Figures
Fig. 1

Study design and population selection.

Fig. 1

Study design and population selection.

Fig. 1

Study design and population selection.

Fig. 2

Kaplan–Meier curve: time to completion…

Fig. 2

Kaplan–Meier curve: time to completion of the FIT. Log-rank test used to assess…

Fig. 2

Kaplan–Meier curve: time to completion of the FIT. Log-rank test used to assess statistical significance. FIT, fecal immunochemical test.