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Showing content from https://pubmed.ncbi.nlm.nih.gov/24796960/ below:

Risk of advanced lesions at first follow-up colonoscopy in high-risk groups as defined by the United Kingdom post-polypectomy surveillance guideline: data from a single U.S. center

. 2014 Aug;80(2):299-306. doi: 10.1016/j.gie.2014.02.1029. Epub 2014 May 3. Risk of advanced lesions at first follow-up colonoscopy in high-risk groups as defined by the United Kingdom post-polypectomy surveillance guideline: data from a single U.S. center

Affiliations

Affiliation

¹ Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

PMID: 24796960
DOI: 10.1016/j.gie.2014.02.1029

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Risk of advanced lesions at first follow-up colonoscopy in high-risk groups as defined by the United Kingdom post-polypectomy surveillance guideline: data from a single U.S. center

Krishna C Vemulapalli et al. Gastrointest Endosc. 2014 Aug.

. 2014 Aug;80(2):299-306. doi: 10.1016/j.gie.2014.02.1029. Epub 2014 May 3. Affiliation

¹ Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

PMID: 24796960
DOI: 10.1016/j.gie.2014.02.1029

Item in Clipboard

Abstract

Background: The United Kingdom (U.K.) post-adenoma resection guidelines recommend earlier surveillance for patients with 5 or more adenomas or 3 to 4 adenomas of which one is 10 mm or larger compared with U.S. guidelines.

Objective: To evaluate the effect of using the U.K. guideline on a U.S. cohort of adenoma patients.

Design: Single-center, retrospective study.

Setting: Indiana University Hospital and an associated ambulatory surgery center.

Patients: A total of 1414 patients with baseline adenoma findings belonging to one of 5 risk categories and with a follow-up colonoscopy more than 200 days later.

Intervention: Colonoscopy, polypectomy.

Main outcome measurements: Incidence of advanced lesions at follow-up colonoscopy.

Results: Advanced neoplasms at follow-up occurred in 16.3% of patients with 5 or more adenomas including 1 that was 10 mm or larger, 8.6% of patients with 3 or 4 adenomas including 1 that was 10 mm or larger, 5% of those with 5 or more adenomas all smaller than 10 mm, 1.8% of those with 3 or 4 adenomas all smaller than 10 mm, and 1.4% of those with 1 to 2 adenomas smaller than 10 mm. Logistic regression analyses showed that the rate of advanced lesions at first follow-up was increased in persons with 3 or more baseline adenomas and at least 1 that is 10 mm or larger compared with those with 1 to 4 small baseline adenomas.

Limitations: Single-center, retrospective study.

Conclusions: Our results indicate the U.K. guideline predicts higher risk groups for advanced neoplasia at first follow-up. Our study had inadequate power to show better prediction of incident cancer. Additional study of other databases is warranted.

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