Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/23715565/ below:

Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial

Randomized Controlled Trial

Affiliations

• ¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. meinholdc@mail.nih.gov

• PMID: 23715565
• PMCID: PMC3691360
• DOI: 10.1200/JCO.2012.48.4691

Item in Clipboard

Randomized Controlled Trial

Cari M Kitahara et al. J Clin Oncol. 2013.

• ¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. meinholdc@mail.nih.gov

• PMID: 23715565
• PMCID: PMC3691360
• DOI: 10.1200/JCO.2012.48.4691

Item in Clipboard

Purpose: Obesity has consistently been linked to an increased risk of colorectal cancer, particularly among men. Whether body mass index (BMI) differentially influences the risk across the stages of colorectal cancer development remains unclear. We evaluated the associations of BMI with colorectal adenoma incidence, adenoma recurrence, and cancer in the context of a large screening trial, in which cases and controls had an equal chance for disease detection.

Methods: We prospectively evaluated the association between baseline BMI and the risk of incident distal adenoma (1,213 cases), recurrent adenoma (752 cases), and incident colorectal cancer (966 cases) among men and women, ages 55 to 74 years, randomly assigned to receive flexible sigmoidoscopy screening as part of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We calculated odds ratios (ORs) and 95% CIs for adenoma incidence and recurrence, and hazard ratios (HRs) and 95% CIs for colorectal cancer incidence, using multivariable-adjusted models.

Results: Compared with normal-weight men (18.5 to 24.9 kg/m(2)), obese men (≥ 30 kg/m(2)) had significantly higher risk of incident adenoma (OR, 1.32; 95% CI, 1.06 to 1.65) and colorectal cancer (HR, 1.48; 95% CI, 1.16 to 1.89) and a borderline increased risk of recurrent adenoma (OR, 1.50; 95% CI, 0.98 to 2.30). No associations were observed for either adenoma or cancer in women.

Conclusion: Data from this large prospective study suggest that obesity is important throughout the natural history of colorectal cancer, at least in men, and colorectal cancer prevention efforts should encourage the achievement and maintenance of a healthy body weight in addition to regular screenings.

PubMed Disclaimer

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

• Dietary fiber intake and risk of colorectal cancer and incident and recurrent adenoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

  Kunzmann AT, Coleman HG, Huang WY, Kitahara CM, Cantwell MM, Berndt SI. Kunzmann AT, et al. Am J Clin Nutr. 2015 Oct;102(4):881-90. doi: 10.3945/ajcn.115.113282. Epub 2015 Aug 12. Am J Clin Nutr. 2015. PMID: 26269366 Free PMC article.

• Carbohydrate, glycemic index, and glycemic load and colorectal adenomas in the Prostate, Lung, Colorectal, and Ovarian Screening Study.

  Flood A, Peters U, Jenkins DJ, Chatterjee N, Subar AF, Church TR, Bresalier R, Weissfeld JL, Hayes RB, Schatzkin A; Prostate, Lung, Colorectal, Ovarian (PLCO) Project Team. Flood A, et al. Am J Clin Nutr. 2006 Nov;84(5):1184-92. doi: 10.1093/ajcn/84.5.1184. Am J Clin Nutr. 2006. PMID: 17093173

• Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial.

  Chudy-Onwugaje K, Huang WY, Su LJ, Purdue MP, Johnson CC, Wang L, Katki HA, Barry KH, Berndt SI. Chudy-Onwugaje K, et al. Cancer. 2021 Sep 1;127(17):3145-3155. doi: 10.1002/cncr.33623. Epub 2021 May 11. Cancer. 2021. PMID: 33974712 Free PMC article.

• Cascade colorectal cancer screening guidelines: a global conceptual model.

  Winawer SJ, Krabshuis J, Lambert R, O'Brien M, Fried M; World Gastroenterology Organization Guidelines Committee. Winawer SJ, et al. J Clin Gastroenterol. 2011 Apr;45(4):297-300. doi: 10.1097/MCG.0b013e3182098e07. J Clin Gastroenterol. 2011. PMID: 21301355 Review.

• The prostate, lung, colorectal, and ovarian cancer screening trial and its associated research resource.

  Zhu CS, Pinsky PF, Kramer BS, Prorok PC, Purdue MP, Berg CD, Gohagan JK. Zhu CS, et al. J Natl Cancer Inst. 2013 Nov 20;105(22):1684-93. doi: 10.1093/jnci/djt281. Epub 2013 Oct 10. J Natl Cancer Inst. 2013. PMID: 24115361 Free PMC article. Review.

• Weight Change and Incident Distal Colorectal Adenoma Risk in the PLCO Cancer Screening Trial.

  He S, Berndt SI, Kunzmann AT, Kitahara CM, Huang WY, Barry KH. He S, et al. JNCI Cancer Spectr. 2022 Feb 1;6(1):pkab098. doi: 10.1093/jncics/pkab098. eCollection 2022 Feb. JNCI Cancer Spectr. 2022. PMID: 35112050 Free PMC article.

• Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer.

  Zhang Q, Deng T, Zhang H, Zuo D, Zhu Q, Bai M, Liu R, Ning T, Zhang L, Yu Z, Zhang H, Ba Y. Zhang Q, et al. Adv Sci (Weinh). 2022 Oct;9(28):e2203357. doi: 10.1002/advs.202203357. Epub 2022 Aug 17. Adv Sci (Weinh). 2022. PMID: 35978266 Free PMC article.

• Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California.

  Juo YY, Gibbons MAM, Dutson E, Lin AY, Yanagawa J, Hines OJ, Eibl G, Chen Y. Juo YY, et al. J Obes. 2018 Sep 19;2018:7014073. doi: 10.1155/2018/7014073. eCollection 2018. J Obes. 2018. PMID: 30327727 Free PMC article.

• Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer.

  Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Gupta S, et al. Gastrointest Endosc. 2020 Mar;91(3):463-485.e5. doi: 10.1016/j.gie.2020.01.014. Epub 2020 Feb 7. Gastrointest Endosc. 2020. PMID: 32044106 Free PMC article. No abstract available.

• The impact of a bodyweight and physical activity intervention (BeWEL) initiated through a national colorectal cancer screening programme: randomised controlled trial.

  Anderson AS, Craigie AM, Caswell S, Treweek S, Stead M, Macleod M, Daly F, Belch J, Rodger J, Kirk A, Ludbrook A, Rauchhaus P, Norwood P, Thompson J, Wardle J, Steele RJ. Anderson AS, et al. BMJ. 2014 Mar 7;348:g1823. doi: 10.1136/bmj.g1823. BMJ. 2014. PMID: 24609919 Free PMC article. Clinical Trial.

1. 1. Eheman C, Henley SJ, Ballard-Barbash R, et al. Annual report to the nation on the status of cancer, 1975-2008, featuring cancers associated with excess weight and lack of sufficient physical activity. Cancer. 2012;118:2338–2366. - PMC - PubMed
2. 1. American Cancer Society. Cancer Facts & Figures 2012. Atlanta, GA: American Cancer Society; 2012.
3. 1. Doll R, Peto R. The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981;66:1191–1308. - PubMed
4. 1. Willett WC. Diet, nutrition, and avoidable cancer. Environ Health Perspect. 1995;103(suppl 8):165–170. - PMC - PubMed
5. 1. Platz EA, Willett WC, Colditz GA, et al. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes Control. 2000;11:579–588. - PubMed

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3