Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/23460319/ below:

Patterns of care and outcome for patients with glioblastoma diagnosed during 2008-2010 in Spain

Affiliations

• ¹ Service of Neurology, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain. fgraus@clinic.ub.es

• PMID: 23460319
• PMCID: PMC3661097
• DOI: 10.1093/neuonc/not013

Item in Clipboard

Francesc Graus et al. Neuro Oncol. 2013 Jun.

• ¹ Service of Neurology, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain. fgraus@clinic.ub.es

• PMID: 23460319
• PMCID: PMC3661097
• DOI: 10.1093/neuonc/not013

Item in Clipboard

Background: To assess management patterns and outcome in patients with glioblastoma multiforme (GBM) treated during 2008-2010 in Spain.

Methods: Retrospective analysis of clinical, therapeutic, and survival data collected through filled questionnaires from patients with histologically confirmed GBM diagnosed in 19 Spanish hospitals.

Results: We identified 834 patients (23% aged >70 years). Surgical resection was achieved in 66% of patients, although the extent of surgery was confirmed by postoperative MRI in only 41%. There were major postoperative complications in 14% of patients, and age was the only independent predictor (Odds ratio [OR], 1.03; 95% confidence interval [CI],1.01-1.05; P = .006). After surgery, 57% received radiotherapy (RT) with concomitant and adjuvant temozolomide, 21% received other regimens, and 22% were not further treated. In patients treated with surgical resection, RT, and chemotherapy (n = 396), initiation of RT ≤42 days was associated with longer progression-free survival (hazard ratio [HR], 0.8; 95% CI, 0.64-0.99; P = .042) but not with overall survival (HR, 0.79; 95% CI, 0.62-1.00; P = .055). Only 32% of patients older than 70 years received RT with concomitant and adjuvant temozolomide. The median survival in this group was 10.8 months (95% CI, 6.8-14.9 months), compared with 17.0 months (95% CI, 15.5-18.4 months; P = .034) among younger patients with GBM treated with the same regimen.

Conclusions: In a community setting, 57% of all patients with GBM and only 32% of older patients received RT with concomitant and adjuvant temozolomide. In patients with surgical resection who were eligible for chemoradiation, initiation of RT ≤42 days was associated with better progression-free survival.

Keywords: glioblastoma multiforme; older patients; practice patterns; radiotherapy delay; surgical complications.

PubMed Disclaimer

Kaplan-Meier estimates of survival in…

Kaplan-Meier estimates of survival in the whole series and patients who received or…

Kaplan-Meier estimates of survival in the whole series and patients who received or not postoperative oncological treatment. MS, median survival.

Progression-free survival (A) and overall…

Progression-free survival (A) and overall survival (B), according to delay to initiation of…

Progression-free survival (A) and overall survival (B), according to delay to initiation of RT. MS, median survival.

Survival among patients stratified by…

Survival among patients stratified by age and treated with the standard protocol of…

Survival among patients stratified by age and treated with the standard protocol of RT with concomitant and adjuvant TMZ. Abbreviation: MS, median survival.

• Effectiveness of temozolomide treatment used at the same time with radiotherapy and adjuvant temozolomide; concomitant therapy of glioblastoma multiforme: multivariate analysis and other prognostic factors.

  Birol Sarica F, Tufan K, Cekinmez M, Sen O, Cem Onal H, Mertsoylu H, Topkan E, Pehlivan B, Erdogan B, Nur Altinors M. Birol Sarica F, et al. J Neurosurg Sci. 2010 Mar;54(1):7-19. J Neurosurg Sci. 2010. PMID: 20436394

• A clinical review of treatment outcomes in glioblastoma multiforme--the validation in a non-trial population of the results of a randomised Phase III clinical trial: has a more radical approach improved survival?

  Rock K, McArdle O, Forde P, Dunne M, Fitzpatrick D, O'Neill B, Faul C. Rock K, et al. Br J Radiol. 2012 Sep;85(1017):e729-33. doi: 10.1259/bjr/83796755. Epub 2012 Jan 3. Br J Radiol. 2012. PMID: 22215883 Free PMC article. Clinical Trial.

• Patterns of care and survival for patients with glioblastoma multiforme diagnosed during 2006.

  Yabroff KR, Harlan L, Zeruto C, Abrams J, Mann B. Yabroff KR, et al. Neuro Oncol. 2012 Mar;14(3):351-9. doi: 10.1093/neuonc/nor218. Epub 2012 Jan 12. Neuro Oncol. 2012. PMID: 22241797 Free PMC article.

• Hypofractionated radiotherapy with or without concurrent temozolomide in elderly patients with glioblastoma multiforme: a review of ten-year single institutional experience.

  Cao JQ, Fisher BJ, Bauman GS, Megyesi JF, Watling CJ, Macdonald DR. Cao JQ, et al. J Neurooncol. 2012 Apr;107(2):395-405. doi: 10.1007/s11060-011-0766-3. Epub 2011 Nov 22. J Neurooncol. 2012. PMID: 22105851 Review.

• The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation.

  Garside R, Pitt M, Anderson R, Rogers G, Dyer M, Mealing S, Somerville M, Price A, Stein K. Garside R, et al. Health Technol Assess. 2007 Nov;11(45):iii-iv, ix-221. doi: 10.3310/hta11450. Health Technol Assess. 2007. PMID: 17999840 Review.

• Super-enhancer-associated TMEM44-AS1 aggravated glioma progression by forming a positive feedback loop with Myc.

  Bian E, Chen X, Cheng L, Cheng M, Chen Z, Yue X, Zhang Z, Chen J, Sun L, Huang K, Huang C, Fang Z, Zhao B, Li J. Bian E, et al. J Exp Clin Cancer Res. 2021 Oct 25;40(1):337. doi: 10.1186/s13046-021-02129-9. J Exp Clin Cancer Res. 2021. PMID: 34696771 Free PMC article.

• Assessment and treatment relevance in elderly glioblastoma patients.

  Bauchet L, Zouaoui S, Darlix A, Menjot de Champfleur N, Ferreira E, Fabbro M, Kerr C, Taillandier L. Bauchet L, et al. Neuro Oncol. 2014 Nov;16(11):1459-68. doi: 10.1093/neuonc/nou063. Epub 2014 May 2. Neuro Oncol. 2014. PMID: 24792440 Free PMC article. Review.

• Discriminating Glioblastoma from Peritumoral Tissue by a Nanohole Array-Based Optical and Label-Free Biosensor.

  García-Milán V, Franco A, Zvezdanova ME, Marcos S, Martin-Laez R, Moreno F, Velasquez C, Fernandez-Luna JL. García-Milán V, et al. Biosensors (Basel). 2023 May 30;13(6):591. doi: 10.3390/bios13060591. Biosensors (Basel). 2023. PMID: 37366956 Free PMC article.

• Clinicopathologic Features and Early Surgical Outcome of Astrocytomas in Eldoret, Kenya.

  Mwita CC, Koech F, Sisenda T, Patel K, Macharia B, Rahangdale D. Mwita CC, et al. J Neurosci Rural Pract. 2018 Jul-Sep;9(3):363-369. doi: 10.4103/jnrp.jnrp_562_17. J Neurosci Rural Pract. 2018. PMID: 30069093 Free PMC article.

• Super-early initiation of temozolomide prolongs the survival of glioblastoma patients without gross-total resection: a retrospective cohort study.

  Jiang H, Zeng W, Ren X, Cui Y, Li M, Yang K, Elbaroody M, Lin S. Jiang H, et al. J Neurooncol. 2019 Aug;144(1):127-135. doi: 10.1007/s11060-019-03211-1. Epub 2019 Jun 7. J Neurooncol. 2019. PMID: 31175579

1. 1. Ohgaki H, Kleihues P. Epidemiology and etiology of gliomas. Acta Neuropathol. 2005;109:93–108. - PubMed
2. 1. Ohgaki H, Kleihues P. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 2005;64:479–489. - PubMed
3. 1. Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466. - PubMed
4. 1. Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352:987–996. - PubMed
5. 1. Yabroff KR, Harlan L, Zeruto C, Abrams J, Mann B. Patterns of care and survival for patients with glioblastoma multiforme diagnosed during 2006. Neuro-Oncol. 2012;14:351–359. - PMC - PubMed

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3