Case Reports
. 2010 Oct 28;363(18):1734-9. doi: 10.1056/NEJMoa1007478. EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors Young Lim Choi 1 , Manabu Soda, Yoshihiro Yamashita, Toshihide Ueno, Junpei Takashima, Takahiro Nakajima, Yasushi Yatabe, Kengo Takeuchi, Toru Hamada, Hidenori Haruta, Yuichi Ishikawa, Hideki Kimura, Tetsuya Mitsudomi, Yoshiro Tanio, Hiroyuki Mano; ALK Lung Cancer Study GroupAffiliations
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Case Reports
EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitorsYoung Lim Choi et al. N Engl J Med. 2010.
Free article . 2010 Oct 28;363(18):1734-9. doi: 10.1056/NEJMoa1007478. Authors Young Lim Choi 1 , Manabu Soda, Yoshihiro Yamashita, Toshihide Ueno, Junpei Takashima, Takahiro Nakajima, Yasushi Yatabe, Kengo Takeuchi, Toru Hamada, Hidenori Haruta, Yuichi Ishikawa, Hideki Kimura, Tetsuya Mitsudomi, Yoshiro Tanio, Hiroyuki Mano; ALK Lung Cancer Study Group AffiliationItem in Clipboard
AbstractThe EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion-type tyrosine kinase is an oncoprotein found in 4 to 5% of non-small-cell lung cancers, and clinical trials of specific inhibitors of ALK for the treatment of such tumors are currently under way. Here, we report the discovery of two secondary mutations within the kinase domain of EML4-ALK in tumor cells isolated from a patient during the relapse phase of treatment with an ALK inhibitor. Each mutation developed independently in subclones of the tumor and conferred marked resistance to two different ALK inhibitors. (Funded by the Ministry of Health, Labor, and Welfare of Japan, and others.).
Comment in[No authors listed] [No authors listed] Nat Rev Cancer. 2010 Dec;10(12):817. doi: 10.1038/nrc2976. Nat Rev Cancer. 2010. PMID: 21155181 No abstract available.
Shen L, Ji HF. Shen L, et al. N Engl J Med. 2011 Feb 24;364(8):777-8. doi: 10.1056/NEJMc1013325. N Engl J Med. 2011. PMID: 21345111 No abstract available.
Kijima T, Takeuchi K, Tetsumoto S, Shimada K, Takahashi R, Hirata H, Nagatomo I, Hoshino S, Takeda Y, Kida H, Goya S, Tachibana I, Kawase I. Kijima T, et al. Cancer Sci. 2011 Aug;102(8):1602-4. doi: 10.1111/j.1349-7006.2011.01970.x. Cancer Sci. 2011. PMID: 21767331
Bunney TD, Wan S, Thiyagarajan N, Sutto L, Williams SV, Ashford P, Koss H, Knowles MA, Gervasio FL, Coveney PV, Katan M. Bunney TD, et al. EBioMedicine. 2015 Mar 1;2(3):194-204. doi: 10.1016/j.ebiom.2015.02.009. EBioMedicine. 2015. PMID: 26097890 Free PMC article.
Schäfer M, Semmler ML, Bernhardt T, Fischer T, Kakkassery V, Ramer R, Hein M, Bekeschus S, Langer P, Hinz B, Emmert S, Boeckmann L. Schäfer M, et al. Cancers (Basel). 2021 Apr 7;13(8):1770. doi: 10.3390/cancers13081770. Cancers (Basel). 2021. PMID: 33917267 Free PMC article. Review.
Park YY, Park ES, Kim SB, Kim SC, Sohn BH, Chu IS, Jeong W, Mills GB, Byers LA, Lee JS. Park YY, et al. PLoS One. 2012;7(9):e44225. doi: 10.1371/journal.pone.0044225. Epub 2012 Sep 7. PLoS One. 2012. PMID: 22970185 Free PMC article.
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