Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/20929881/ below:

Mammographic density and risk of second breast cancer after ductal carcinoma in situ

Affiliations

• ¹ Division of Research, Kaiser Permanente Medical Care Program, Kaiser Permanente, Oakland, California, USA. Laurel.Habel@kp.org

• PMID: 20929881
• DOI: 10.1158/1055-9965.EPI-10-0769

Item in Clipboard

Laurel A Habel et al. Cancer Epidemiol Biomarkers Prev. 2010 Oct.

• ¹ Division of Research, Kaiser Permanente Medical Care Program, Kaiser Permanente, Oakland, California, USA. Laurel.Habel@kp.org

• PMID: 20929881
• DOI: 10.1158/1055-9965.EPI-10-0769

Item in Clipboard

Background: We examined whether mammographic density predicts risk of second breast cancers among patients with ductal carcinoma in situ (DCIS).

Methods: The study included DCIS patients diagnosed during 1990 to 1997 and treated with breast-conserving surgery at Kaiser Permanente Northern California. Medical records were reviewed for clinical factors and subsequent breast cancers (DCIS and invasive). Ipsilateral mammograms from the index DCIS were assessed for density without knowledge of subsequent cancer status. Cox regression modeling was used to examine the association between mammographic density and risk of breast cancer events.

Results: Of the 935 eligible DCIS patients, 164 (18%) had a subsequent ipsilateral breast cancer, and 59 (6%) had a new primary cancer in the contralateral breast during follow-up (median, 103 mo). Those with the greatest total area of density (upper 20% of values) were at increased risk for invasive disease in either breast [hazard ratio (HR), 2.1; 95% confidence interval (95% CI), 1.2-3.8] or any cancer (DCIS or invasive) in the ipsilateral (HR, 1.7; 95% CI, 1.0-2.9) or contralateral (HR, 3.0; 95% CI, 1.3-6.9) breast compared with those with the smallest area of density (bottom 20%). HRs for these same end points comparing those in the highest with those in the lowest American College of Radiology Breast Imaging Reporting and Data System category were 1.6 (95% CI, 0.7-3.6), 1.3 (95% CI, 0.7-2.6), and 5.0 (95% CI, 1.4-17.9), respectively. There was a suggestion of increasing risk of contralateral, but not ipsilateral, cancer with increasing percent density.

Conclusions: Women with mammographically dense breasts may be at higher risk of subsequent breast cancer, especially in the contralateral breast.

Impact: Information about mammographic density may help with DCIS treatment decisions.

©2010 AACR.

PubMed Disclaimer

• Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ.

  Hwang ES, Miglioretti DL, Ballard-Barbash R, Weaver DL, Kerlikowske K; National Cancer Institute Breast Cancer Surveillance Consortium. Hwang ES, et al. Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2587-93. doi: 10.1158/1055-9965.EPI-07-0458. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 18086762

• Comparison of the association of mammographic density and clinical factors with ductal carcinoma in situ versus invasive ductal breast cancer in Korean women.

  Ko H, Shin J, Lee JE, Nam SJ, Nguyen TL, Hopper JL, Song YM. Ko H, et al. BMC Cancer. 2017 Dec 5;17(1):821. doi: 10.1186/s12885-017-3841-0. BMC Cancer. 2017. PMID: 29207971 Free PMC article.

• Mammographic density and breast cancer after ductal carcinoma in situ.

  Habel LA, Dignam JJ, Land SR, Salane M, Capra AM, Julian TB. Habel LA, et al. J Natl Cancer Inst. 2004 Oct 6;96(19):1467-72. doi: 10.1093/jnci/djh260. J Natl Cancer Inst. 2004. PMID: 15467036 Free PMC article.

• The risk of a contralateral breast cancer among women diagnosed with ductal and lobular breast carcinoma in situ: data from the Connecticut Tumor Registry.

  Claus EB, Stowe M, Carter D, Holford T. Claus EB, et al. Breast. 2003 Dec;12(6):451-6. doi: 10.1016/s0960-9776(03)00152-8. Breast. 2003. PMID: 14659121 Review.

• Imaging for the diagnosis and management of ductal carcinoma in situ.

  D'Orsi CJ. D'Orsi CJ. J Natl Cancer Inst Monogr. 2010;2010(41):214-7. doi: 10.1093/jncimonographs/lgq037. J Natl Cancer Inst Monogr. 2010. PMID: 20956833 Free PMC article. Review.

• Mammographic density and breast cancer risk: current understanding and future prospects.

  Boyd NF, Martin LJ, Yaffe MJ, Minkin S. Boyd NF, et al. Breast Cancer Res. 2011;13(6):223. doi: 10.1186/bcr2942. Epub 2011 Nov 1. Breast Cancer Res. 2011. PMID: 22114898 Free PMC article. Review.

• Breast Mammographic Density: Stromal Implications on Breast Cancer Detection and Therapy.

  Fernández-Nogueira P, Mancino M, Fuster G, Bragado P, Puig MP, Gascón P, Casado FJ, Carbó N. Fernández-Nogueira P, et al. J Clin Med. 2020 Mar 12;9(3):776. doi: 10.3390/jcm9030776. J Clin Med. 2020. PMID: 32178425 Free PMC article. Review.

• Dose-dependent effect of mammographic breast density on the risk of contralateral breast cancer.

  Chowdhury M, Euhus D, O'Donnell M, Onega T, Choudhary PK, Biswas S. Chowdhury M, et al. Breast Cancer Res Treat. 2018 Jul;170(1):143-148. doi: 10.1007/s10549-018-4736-8. Epub 2018 Mar 6. Breast Cancer Res Treat. 2018. PMID: 29511964 Free PMC article.

• Does Breast Density Increase the Risk of Re-excision for Women with Breast Cancer Having Breast-Conservation Therapy?

  Walsh SM, Brennan SB, Zabor EC, Rosenberger LH, Stempel M, Lebron-Zapata L, Gemignani ML. Walsh SM, et al. Ann Surg Oncol. 2019 Dec;26(13):4246-4253. doi: 10.1245/s10434-019-07647-7. Epub 2019 Aug 8. Ann Surg Oncol. 2019. PMID: 31396783 Free PMC article.

• Mammographic density: a potential monitoring biomarker for adjuvant and preventative breast cancer endocrine therapies.

  Shawky MS, Martin H, Hugo HJ, Lloyd T, Britt KL, Redfern A, Thompson EW. Shawky MS, et al. Oncotarget. 2017 Jan 17;8(3):5578-5591. doi: 10.18632/oncotarget.13484. Oncotarget. 2017. PMID: 27894075 Free PMC article. Review.

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3