Home - News ( United States | United Kingdom | Italy | Germany ) - Football scores

Showing content from https://pubmed.ncbi.nlm.nih.gov/19844187/ below:

Epidermal growth factor receptor mutation and pathologic-radiologic correlation between multiple lung nodules with ground-glass opacity differentiates multicentric origin from intrapulmonary spread

Affiliations

• ¹ Department of Pathology, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, Republic of Korea.

• PMID: 19844187
• DOI: 10.1097/JTO.0b013e3181bc9731

Item in Clipboard

Jin-Haeng Chung et al. J Thorac Oncol. 2009 Dec.

• ¹ Department of Pathology, Seoul National University College of Medicine, Seongnam, Gyeonggi-do, Republic of Korea.

• PMID: 19844187
• DOI: 10.1097/JTO.0b013e3181bc9731

Item in Clipboard

Introduction: No standard guidelines detailing recommendations for the selection and treatment for multiple lung nodules with ground-glass opacity (GGO) have been established. For treatment decision, we analyzed epidermal growth factor receptor (EGFR)/K-ras somatic aberrations and pathologic-radiologic correlation in multiple lung nodules presented as GGO to differentiate multifocal lesions from intrapulmonary spread.

Methods: Twenty-four patients with multiple lung nodules presented as GGO were identified to investigate somatic mutations of EGFR (exon 18-21) and K-ras (codons 2, 13, and 61). This series included 18 atypical adenomatous hyperplasias (AAH), 15 bronchioloalveolar carcinomas (BAC), and 23 adenocarcinomas (ADC) obtained from 24 patients.

Results: High frequency of discordant EGFR mutations (17 of 24, 70.8%) could discriminate tumor clonality (18 of 24, 75%) of multiple lung neoplastic nodules presented as GGO. EGFR mutations were common in AAH (38.9%), BAC (46.7%), and ADC (39.1%). In case 4, AAH and BAC had different mutational changes, and in case 10, the BAC lesion contains EGFR mutation that is not in the invasive ADC. In case 17, the BAC had more mutational changes than the carcinoma. The pure GGO appearance in the radiologic examination corresponded preinvasive pathologic change.

Conclusions: This study showed that synchronous BAC and/or ADC can have different EGFR or K-ras mutational profiles suggesting these lesions arise as independent events rather than intrapulmonary spread or systemic metastasis. This has significant implication in staging and treatment. These findings might be a clue to establish guidelines of the multiple neoplastic lung nodules with GGO.

PubMed Disclaimer

• Epidermal growth factor receptor mutation and p53 overexpression during the multistage progression of small adenocarcinoma of the lung.

  Yoo SB, Chung JH, Lee HJ, Lee CT, Jheon S, Sung SW. Yoo SB, et al. J Thorac Oncol. 2010 Jul;5(7):964-9. doi: 10.1097/JTO.0b013e3181dd15c0. J Thorac Oncol. 2010. PMID: 20512074

• Ground-glass opacity nodules: histopathology, imaging evaluation, and clinical implications.

  Lee HY, Lee KS. Lee HY, et al. J Thorac Imaging. 2011 May;26(2):106-18. doi: 10.1097/RTI.0b013e3181fbaa64. J Thorac Imaging. 2011. PMID: 21508733 Review.

• Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.

  Yoshida Y, Shibata T, Kokubu A, Tsuta K, Matsuno Y, Kanai Y, Asamura H, Tsuchiya R, Hirohashi S. Yoshida Y, et al. Lung Cancer. 2005 Oct;50(1):1-8. doi: 10.1016/j.lungcan.2005.04.012. Lung Cancer. 2005. PMID: 15950315

• Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.

  Ishida M, Igarashi T, Teramoto K, Hanaoka J, Iwai M, Yoshida K, Kagotani A, Tezuka N, Okabe H. Ishida M, et al. Int J Clin Exp Pathol. 2013 Oct 15;6(11):2597-602. eCollection 2013. Int J Clin Exp Pathol. 2013. PMID: 24228126 Free PMC article. Review.

• What do we know about ground-glass opacity nodules in the lung?

  Lee CT. Lee CT. Transl Lung Cancer Res. 2015 Oct;4(5):656-9. doi: 10.3978/j.issn.2218-6751.2015.04.05. Transl Lung Cancer Res. 2015. PMID: 26629441 Free PMC article.

• The Diagnosis of Intrapulmonary Metastasis Multifocal Pulmonary Ground-Glass Nodules Based on Oncogenic Driver Mutation: Two Case Reports and Review of Literature.

  Liang Y, He K, Zhang B, Chen K, Pan L, Mao G, Feng Y, Chen S, Ma H. Liang Y, et al. Front Surg. 2022 Jan 20;8:812559. doi: 10.3389/fsurg.2021.812559. eCollection 2021. Front Surg. 2022. PMID: 35127807 Free PMC article.

• Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity.

  Ko SJ, Lee YJ, Park JS, Cho YJ, Yoon HI, Chung JH, Kim TJ, Lee KW, Kim K, Jheon S, Kim H, Lee JH, Lee CT. Ko SJ, et al. BMC Cancer. 2014 May 3;14:312. doi: 10.1186/1471-2407-14-312. BMC Cancer. 2014. PMID: 24885886 Free PMC article.

• Significance of nonmucinous lepidic component with mild nuclear atypia in the discrimination of multiple primary lung cancers from intrapulmonary metastases.

  Sun W, Liu Y, Liu XY, Lin DM, Lv N. Sun W, et al. Int J Clin Exp Pathol. 2014 Oct 15;7(11):7583-96. eCollection 2014. Int J Clin Exp Pathol. 2014. PMID: 25550795 Free PMC article.

RetroSearch is an open source project built by @garambo | Open a GitHub Issue

Search and Browse the WWW like it's 1997 | Search results from DuckDuckGo

HTML: 3.2 | Encoding: UTF-8 | Version: 0.7.3