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Showing content from https://pubmed.ncbi.nlm.nih.gov/19520905/ below:

A randomized study of lung cancer screening with spiral computed tomography: three-year results from the DANTE trial

Randomized Controlled Trial

Collaborators, Affiliations

• DANTE Study Group: Silvio Cavuto, Marco Alloisio, Edoardo Bottoni, Umberto Cariboni, Valentina Errico, Giorgio Ferraroli, Matteo Incarbone, Maurizio Infante, Francesco Inzirillo, Gianluigi Ravasi, Diego Ruzzante, Alberto Testori, Emanuele Voulaz, Luca Balzarini, Giorgio Brambilla, Sara Imparato, Fabio Lutman, Vittorio Pedicini, Dario Poretti, Pasquala Ragucci, Giuseppe Chiesa, Giovanni Guanella, Alberto Meroni, Eliseo Passera, Adriano Rizzi, Enzo Angeli, Emanuela Torda, Alessandro Zanello, Aranzulla Giuseppe, Michele Caruso, Maurizio Chiarenza, Ekaterina Barishnykova, Paolo Bianchi, Anna Destro, Giovanna Gribaudi, Massimo Roncalli, Arturo Chiti, Gianluigi Ciocia, Marcello Rodari, Raffaele Cavina, Federico Cappuzzo, Giovanni Ceresoli, Isabella Garassino, Armando Santoro, Paolo Zucali, Piera Navarria, Marta Scorsetti, Michele Ciccarelli, Elena Paracchini, Antonio Voza, Arnaldo Alessandrini, Michele Tedeschi, Emanuela Morenghi

• ¹ Thoracic Surgery Department, Istituto Clinico Humanitas, Milan, Italy. maurizio.infante@humanitas.it

• PMID: 19520905
• DOI: 10.1164/rccm.200901-0076OC

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Randomized Controlled Trial

Maurizio Infante et al. Am J Respir Crit Care Med. 2009.

• DANTE Study Group: Silvio Cavuto, Marco Alloisio, Edoardo Bottoni, Umberto Cariboni, Valentina Errico, Giorgio Ferraroli, Matteo Incarbone, Maurizio Infante, Francesco Inzirillo, Gianluigi Ravasi, Diego Ruzzante, Alberto Testori, Emanuele Voulaz, Luca Balzarini, Giorgio Brambilla, Sara Imparato, Fabio Lutman, Vittorio Pedicini, Dario Poretti, Pasquala Ragucci, Giuseppe Chiesa, Giovanni Guanella, Alberto Meroni, Eliseo Passera, Adriano Rizzi, Enzo Angeli, Emanuela Torda, Alessandro Zanello, Aranzulla Giuseppe, Michele Caruso, Maurizio Chiarenza, Ekaterina Barishnykova, Paolo Bianchi, Anna Destro, Giovanna Gribaudi, Massimo Roncalli, Arturo Chiti, Gianluigi Ciocia, Marcello Rodari, Raffaele Cavina, Federico Cappuzzo, Giovanni Ceresoli, Isabella Garassino, Armando Santoro, Paolo Zucali, Piera Navarria, Marta Scorsetti, Michele Ciccarelli, Elena Paracchini, Antonio Voza, Arnaldo Alessandrini, Michele Tedeschi, Emanuela Morenghi

• ¹ Thoracic Surgery Department, Istituto Clinico Humanitas, Milan, Italy. maurizio.infante@humanitas.it

• PMID: 19520905
• DOI: 10.1164/rccm.200901-0076OC

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Rationale: Screening for lung cancer with modern imaging technology may decrease lung cancer mortality, but encouraging results have only been obtained in uncontrolled studies.

Objectives: To explore the effect of screening with low-dose spiral computed tomography (LDCT) on lung cancer mortality. Secondary endpoints are incidence, stage at diagnosis, and resectability.

Methods: Male subjects, aged 60 to 75 years, smokers of 20 or more pack-years, were randomized to screening with LDCT or control groups. All participants underwent a baseline, once-only chest X-ray and sputum cytology examination. Screening-arm subjects had LDCT upon accrual to be repeated every year for 4 years, whereas controls had a yearly medical examination only.

Measurements and main results: A total of 2,811 subjects were randomized and 2,472 were enrolled (LDCT, 1,276; control, 1,196). After a median follow-up of 33 months, lung cancer was detected in 60 (4.7%) patients receiving LDCT and 34 (2.8%) control subjects (P = 0.016). Resectability rates were similar in both groups. More patients with stage I disease were detected by LDCT (54 vs. 34%; P = 0.06) and fewer cases were detected in the screening arm due to intercurrent symptoms. However, the number of advanced lung cancer cases was the same as in the control arm. Twenty patients in the LDCT group (1.6%) and 20 controls (1.7%) died of lung cancer, whereas 26 and 25 died of other causes, respectively.

Conclusions: The mortality benefit from lung cancer screening by LDCT might be far smaller than anticipated.

PubMed Disclaimer

• Long-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography.

  Infante M, Cavuto S, Lutman FR, Passera E, Chiarenza M, Chiesa G, Brambilla G, Angeli E, Aranzulla G, Chiti A, Scorsetti M, Navarria P, Cavina R, Ciccarelli M, Roncalli M, Destro A, Bottoni E, Voulaz E, Errico V, Ferraroli G, Finocchiaro G, Toschi L, Santoro A, Alloisio M; DANTE Study Group. Infante M, et al. Am J Respir Crit Care Med. 2015 May 15;191(10):1166-75. doi: 10.1164/rccm.201408-1475OC. Am J Respir Crit Care Med. 2015. PMID: 25760561 Clinical Trial.

• Lung cancer screening with spiral CT: baseline results of the randomized DANTE trial.

  Infante M, Lutman FR, Cavuto S, Brambilla G, Chiesa G, Passera E, Angeli E, Chiarenza M, Aranzulla G, Cariboni U, Alloisio M, Incarbone M, Testori A, Destro A, Cappuzzo F, Roncalli M, Santoro A, Ravasi G; DANTE Study Group. Infante M, et al. Lung Cancer. 2008 Mar;59(3):355-63. doi: 10.1016/j.lungcan.2007.08.040. Epub 2007 Oct 23. Lung Cancer. 2008. PMID: 17936405 Clinical Trial.

• Annual or biennial CT screening versus observation in heavy smokers: 5-year results of the MILD trial.

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• Computed tomography screening for lung cancer: has it finally arrived? Implications of the national lung screening trial.

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• A meta-analysis: is low-dose computed tomography a superior method for risky lung cancers screening population?

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• Patients with a Previous History of Malignancy Undergoing Lung Cancer Screening: Clinical Characteristics and Radiologic Findings.

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• National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers.

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• Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.

  Bonney A, Malouf R, Marchal C, Manners D, Fong KM, Marshall HM, Irving LB, Manser R. Bonney A, et al. Cochrane Database Syst Rev. 2022 Aug 3;8(8):CD013829. doi: 10.1002/14651858.CD013829.pub2. Cochrane Database Syst Rev. 2022. PMID: 35921047 Free PMC article. Review.

• UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer.

  Baldwin DR, Duffy SW, Wald NJ, Page R, Hansell DM, Field JK. Baldwin DR, et al. Thorax. 2011 Apr;66(4):308-13. doi: 10.1136/thx.2010.152066. Epub 2011 Feb 11. Thorax. 2011. PMID: 21317179 Free PMC article. Clinical Trial.

• Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

  Mazzone PJ, Silvestri GA, Souter LH, Caverly TJ, Kanne JP, Katki HA, Wiener RS, Detterbeck FC. Mazzone PJ, et al. Chest. 2021 Nov;160(5):e427-e494. doi: 10.1016/j.chest.2021.06.063. Epub 2021 Jul 13. Chest. 2021. PMID: 34270968 Free PMC article.

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